scholarly journals Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective

Genomics ◽  
2020 ◽  
Vol 112 (2) ◽  
pp. 1290-1299 ◽  
Author(s):  
Md. Rezanur Rahman ◽  
Tania Islam ◽  
Toyfiquz Zaman ◽  
Md. Shahjaman ◽  
Md. Rezaul Karim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Targets ◽  
Molecular Signatures ◽  
Novel Therapeutic

scholarly journals Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Shingo Tsuji ◽  
Takeshi Hase ◽  
Ayako Yachie-Kinoshita ◽  
Taiko Nishino ◽  
Samik Ghosh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Drug Target ◽  
Target Genes ◽  
Drug Repositioning ◽  
Therapeutic Targets ◽  
Machine Learning Techniques ◽  
Computational Framework ◽  
Novel Therapeutic

Abstract Background Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets for FDA-approved drugs. As a result, it is inevitable to develop powerful computational tools that can identify potential novel therapeutic targets. Fortunately, the human protein-protein interaction network (PIN) could be a useful resource to achieve this objective. Methods In this study, we developed a deep learning-based computational framework that extracts low-dimensional representations of high-dimensional PIN data. Our computational framework uses latent features and state-of-the-art machine learning techniques to infer potential drug target genes. Results We applied our computational framework to prioritize novel putative target genes for Alzheimer’s disease and successfully identified key genes that may serve as novel therapeutic targets (e.g., DLG4, EGFR, RAC1, SYK, PTK2B, SOCS1). Furthermore, based on these putative targets, we could infer repositionable candidate-compounds for the disease (e.g., tamoxifen, bosutinib, and dasatinib). Conclusions Our deep learning-based computational framework could be a powerful tool to efficiently prioritize new therapeutic targets and enhance the drug repositioning strategy.

scholarly journals Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

2014 ◽  
Vol 88 (4) ◽  
pp. 617-630 ◽  
Author(s):  
David A. Bennett ◽  
Lei Yu ◽  
Philip L. De Jager
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Targets ◽  
Lead Compounds ◽  
Novel Therapeutic

scholarly journals Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

2013 ◽  
Vol 5 (5) ◽  
pp. 49 ◽  
Author(s):  
Amy M Pooler ◽  
Manuela Polydoro ◽  
Susanne Wegmann ◽  
Samantha B Nicholls ◽  
Tara L Spires-Jones ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Targets ◽  
Tau Pathology ◽  
Disease Identification ◽  
Novel Therapeutic

Genetic evidence for microglia-associated pathways as therapeutic targets for Alzheimer's disease

2016 ◽  
Vol 39 ◽  
pp. S6
Author(s):  
Claudio Villegas-Llerena ◽  
Mar Matarin ◽  
John Hardy ◽  
Jennifer Pocock
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Targets ◽  
Genetic Evidence

Alzheimer’s disease: from pathogenesis to novel therapeutic approaches

Therapy ◽  
2009 ◽  
Vol 6 (2) ◽  
pp. 259-277 ◽  
Author(s):  
Elio Scarpini ◽  
Daniela Galimberti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

scholarly journals Heparan sulfate proteoglycans and heparanases in Alzheimer's disease: current outlook and potential therapeutic targets

2017 ◽  
Vol 12 (6) ◽  
pp. 914 ◽  
Author(s):  
Iván Fernández-Vega ◽  
Laura Lorente-Gea ◽  
Beatriz García ◽  
Carla Martín ◽  
LuisM Quirós
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heparan Sulfate ◽  
Therapeutic Targets ◽  
Heparan Sulfate Proteoglycans
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