Squamous cell carcinoma arising in mature cystic teratoma of the ovary: A case series and review of the literature

Mature cystic teratomas account for 30–45 % of all ovarian tumours. Malignant transformation of these tumours is rare with squamous cell carcinoma (SCC) being the commonest histological type. During a 24-year period (1986–2010) we identified six women treated for SCC arising in a mature cystic teratoma at our institution. Each case was reviewed retrospectively recording presenting symptoms, tumour markers, preoperative imaging, tumour stage, management and outcome. Durable responses are difficult to achieve but best treatment response was seen in a woman who had partial response to chemo-radiotherapy. Concurrent chemo-radiation may be considered for disease confined to the pelvis.

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Disease confined within the ovary and smaller amount of ascites are good prognostic factors for survival of patients with squamous cell carcinoma arising from mature cystic teratoma of the ovary: A case series in Korea and review of the published reports

Journal of Obstetrics and Gynaecology Research ◽

10.1111/j.1447-0756.2008.00841.x ◽

2009 ◽

Vol 35 (1) ◽

pp. 99-105 ◽

Cited By ~ 6

Author(s):

Hee Seung Kim ◽

Jae Weon Kim ◽

Hyun Hoon Chung ◽

Noh-Hyun Park ◽

Yong-Sang Song ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Prognostic Factors ◽

Cell Carcinoma ◽

Squamous Cell ◽

Case Series ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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An ovarian mature cystic teratoma evolving in squamous cell carcinoma: A case report and review of the literature

Gynecologic Oncology Reports ◽

10.1016/j.gore.2016.12.005 ◽

2017 ◽

Vol 19 ◽

pp. 27-30 ◽

Cited By ~ 6

Author(s):

C Goudeli ◽

A Varytimiadi ◽

N Koufopoulos ◽

J Syrios ◽

E Terzakis

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cystic Teratoma ◽

Mature Cystic Teratoma ◽

Review Of The Literature

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Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy: a case report

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-008-0573-z ◽

2008 ◽

Vol 278 (3) ◽

pp. 287-290 ◽

Cited By ~ 10

Author(s):

Keiko Mekaru ◽

Shigeru Kamiyama ◽

Hitoshi Masamoto ◽

Chiaki Yagi ◽

Makoto Hirakawa ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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Squamous cell carcinoma in mature cystic teratoma of the ovary

Medicinski pregled ◽

10.2298/mpns1210429a ◽

2012 ◽

Vol 65 (9-10) ◽

pp. 429-431 ◽

Cited By ~ 2

Author(s):

Jelena Amidzic ◽

Matilda Djolai ◽

Mihaela Mocko-Kacanski ◽

Aleksandar Gluhovic ◽

Jelena Ilic ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Rare Complication ◽

Cystic Teratoma ◽

Internal Surface ◽

Cystic Mass ◽

Mature Cystic Teratoma ◽

Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

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