Initial safety and activity findings from a phase IB escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα-targeting antibody-drug conjugate (ADC), with pembrolizumab in platinum-resistant epithelial ovarian cancer (EOC) patients

Folate Receptor ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Phase Ib ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2020.01.037 ◽

2020 ◽

Vol 157 (2) ◽

pp. 379-385 ◽

Cited By ~ 7

Author(s):

David M. O'Malley ◽

Ursula A. Matulonis ◽

Michael J. Birrer ◽

Cesar M. Castro ◽

Lucy Gilbert ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Phase Ib ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

IMGN853 (mirvetuximab soravtansine), a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC): Single-agent activity in platinum-resistant epithelial ovarian cancer (EOC) patients (pts).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.5567 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. 5567-5567 ◽

Cited By ~ 2

Author(s):

Kathleen N. Moore ◽

Lainie P. Martin ◽

Ursula A. Matulonis ◽

Jason A. Konner ◽

Shelly Marie Seward ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Single Agent ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

FORWARD I (GOG 3011): A phase III study of mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate (ADC), versus chemotherapy in patients (pts) with platinum-resistant ovarian cancer (PROC)

Annals of Oncology ◽

10.1093/annonc/mdz250 ◽

2019 ◽

Vol 30 ◽

pp. v403 ◽

Cited By ~ 8

Author(s):

K. Moore ◽

A. Oza ◽

N. Colombo ◽

A. Oaknin ◽

G. Scambia ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Phase Iii ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

Phase Iii Study ◽

Mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), with pembrolizumab in platinum-resistant ovarian cancer (PROC): Initial results of an expansion cohort from FORWARD II, a phase Ib study

Annals of Oncology ◽

10.1093/annonc/mdy285.157 ◽

2018 ◽

Vol 29 ◽

pp. viii339 ◽

Cited By ~ 6

Author(s):

U.A. Matulonis ◽

K.N. Moore ◽

L.P. Martin ◽

I.B. Vergote ◽

C. Castro ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Antibody Drug Conjugate ◽

Phase Ib ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

Expansion Cohort ◽

Initial Results ◽

Mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate (ADC), in combination with carboplatin and bevacizumab: Initial results from a phase Ib study in patients (pts) with ovarian cancer

Annals of Oncology ◽

10.1093/annonc/mdz250.036 ◽

2019 ◽

Vol 30 ◽

pp. v419-v420

Author(s):

D. O'Malley ◽

D. Richardson ◽

I.B. Vergote ◽

L. Gilbert ◽

L.P. Martin ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Phase Ib ◽

Receptor Alpha ◽

Drug Conjugate ◽

Initial Results ◽

Mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients (pts) with platinum-resistant ovarian cancer: Maturing safety and activity profile from the FORWARD II phase 1b study.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.5549 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. 5549-5549

Author(s):

David M. O'Malley ◽

Lainie P. Martin ◽

Lucy Gilbert ◽

Ignace Vergote ◽

Ursula A. Matulonis ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Activity Profile ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

Phase 1B ◽

Abstract C47: Association of folate receptor alpha (FRα) expression level and clinical activity of IMGN853 (mirvetuximab soravtansine), a FRα-targeting antibody-drug conjugate (ADC), in FRα -expressing platinum-resistant epithelial ovarian cancer (EOC) patients (pts)

10.1158/1535-7163.targ-15-c47 ◽

2015 ◽

Cited By ~ 2

Author(s):

Lainie P. Martin ◽

Kathleen Moore ◽

David M. O'Malley ◽

Shelley Seward ◽

Todd M. Bauer ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Expression Level ◽

Clinical Activity ◽

Antibody Drug Conjugate ◽

Receptor Alpha ◽

Drug Conjugate ◽

Platinum Resistant ◽

Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha–Targeting Antibody-Drug Conjugate, Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models

Neoplasia ◽

10.1016/j.neo.2016.11.002 ◽

2016 ◽

Vol 18 (12) ◽

pp. 775-784 ◽

Cited By ~ 29

Author(s):

Jose F. Ponte ◽

Olga Ab ◽

Leanne Lanieri ◽

Jenny Lee ◽

Jennifer Coccia ◽

...

Keyword(s):

Ovarian Cancer ◽

Folate Receptor ◽

Standard Of Care ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Receptor Alpha ◽

Drug Conjugate ◽

Cancer Models ◽

Relationship of pharmacokinetics (PK), toxicity, and initial evidence of clinical activity with IMGN853, a folate receptor alpha (FRa) targeting antibody drug conjugate in patients (Pts) with epithelial ovarian cancer (EOC) and other FRa-positive solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.5571 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 5571-5571 ◽

Cited By ~ 4

Author(s):

Kathleen N. Moore ◽

Joseph Ponte ◽

Patricia LoRusso ◽

Michael J. Birrer ◽

Todd Michael Bauer ◽

...

Keyword(s):

Ovarian Cancer ◽

Solid Tumors ◽

Folate Receptor ◽

Clinical Activity ◽

Antibody Drug Conjugate ◽

Receptor Alpha ◽

Drug Conjugate ◽

Relationship Of ◽

Safety Profile of Mirvetuximab Soravtansine, a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Patients with Recurrent Ovarian Cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2019.11.066 ◽

2020 ◽

Vol 156 (3) ◽

pp. e15-e16

Author(s):

Kathleen G. Essel ◽

Lainie P. Martin ◽

David M. O’Malley ◽

Ursula Matulonis ◽

Jason A. Konner ◽

...

Keyword(s):

Ovarian Cancer ◽

Safety Profile ◽

Folate Receptor ◽

Recurrent Ovarian Cancer ◽

Antibody Drug Conjugate ◽

Folate Receptor Alpha ◽

Receptor Alpha ◽

Drug Conjugate ◽