Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells

2004 ◽  
Vol 37 (2) ◽  
pp. 537-546 ◽  
Author(s):  
J HIROKI
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Rho Kinase ◽  
Muscle Cells ◽  
Inflammatory Stimuli

scholarly journals Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells

2016 ◽  
Vol 34 (2) ◽  
pp. 253-265 ◽  
Author(s):  
Andrea Aguado ◽  
Thierry Fischer ◽  
Cristina Rodríguez ◽  
Adrian Manea ◽  
José Martínez-González ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inflammatory Stimuli ◽  
Hu Antigen R

scholarly journals Contribution of Rho A and Rho Kinase to Platelet-Derived Growth Factor-BB-Induced Proliferation of Vascular Smooth Muscle Cells.

2003 ◽  
Vol 10 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Masumi Kamiyama ◽  
Kazunori Utsunomiya ◽  
Kanta Taniguchi ◽  
Tamotsu Yokota ◽  
Hideaki Kurata ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Rho Kinase ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor ◽  
Rho A

Coronary artery spasm

2021 ◽  
pp. 16-18
Author(s):  
Hiroaki Shimokawa ◽  
Jun Takahashi
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Coronary Artery Spasm ◽  
Bypass Graft ◽  
Rho Kinase ◽  
Muscle Cells ◽  
Inflammatory Changes

Coronary artery spasm is a condition in which an epicardial coronary artery or coronary bypass graft exhibits abnormal transient constriction with the possible or subsequent development of myocardial ischaemia. Porcine models have demonstrated the important role of atherosclerotic/inflammatory changes of the coronary artery and established that hypercontraction of vascular smooth muscle cells plays a central role in the genesis of spasm and is, in part, dependent on activation of Rho-kinase, a molecular switch for vascular smooth muscle cell contraction. Fasudil, which is used for the treatment of cerebral vasospasm in Japan, is metabolized to hydroxyfasudil and functions as a selective Rho-kinase inhibitor. Recent studies demonstrated that inflammatory changes in the adventitia of the coronary artery play an important role for Rho-kinase activation of vascular smooth muscle cells. Prevention and treatment of coronary spasm is important in preventing acute coronary syndromes and sudden cardiac death.

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