The impact of HIV treatment as prevention in the presence of other prevention strategies: Lessons learned from a review of mathematical models set in resource-rich countries

2014 ◽  
Vol 58 ◽  
pp. 1-8 ◽  
Author(s):  
Dana Paquette ◽  
Dena Schanzer ◽  
Hongbin Guo ◽  
Margaret Gale-Rowe ◽  
Tom Wong
Keyword(s):  
Mathematical Models ◽  
Hiv Treatment ◽  
Lessons Learned ◽  
Treatment As Prevention ◽  
Prevention Strategies ◽  
Hiv Treatment As Prevention ◽  
Rich Countries ◽  
The Impact

scholarly journals HIV Treatment as Prevention: Optimising the Impact of Expanded HIV Treatment Programmes

PLoS Medicine ◽  
2012 ◽  
Vol 9 (7) ◽  
pp. e1001258 ◽  
Author(s):  
Wim Delva ◽  
Jeffrey W. Eaton ◽  
Fei Meng ◽  
Christophe Fraser ◽  
Richard G. White ◽  
...  
Keyword(s):  
Hiv Treatment ◽  
Treatment As Prevention ◽  
Hiv Treatment As Prevention ◽  
The Impact

scholarly journals HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Jing Wu ◽  
Jessie L. Norris ◽  
Yujiang Jia ◽  
Ning Wang
Keyword(s):  
Mathematical Models ◽  
Hiv Transmission ◽  
Dynamic Models ◽  
Hiv Infections ◽  
Hiv Treatment ◽  
Treatment As Prevention ◽  
Poor Countries ◽  
Input Variables ◽  
Hiv Treatment As Prevention ◽  
Preventive Effects

The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission.

scholarly journals HIV Treatment as Prevention: Debate and Commentary—Will Early Infection Compromise Treatment-as-Prevention Strategies?

PLoS Medicine ◽  
2012 ◽  
Vol 9 (7) ◽  
pp. e1001232 ◽  
Author(s):  
Myron S. Cohen ◽  
Christopher Dye ◽  
Christophe Fraser ◽  
William C. Miller ◽  
Kimberly A. Powers ◽  
...  
Keyword(s):  
Hiv Treatment ◽  
Early Infection ◽  
Treatment As Prevention ◽  
Prevention Strategies ◽  
Hiv Treatment As Prevention

scholarly journals Changing Knowledge and Attitudes Towards HIV Treatment-as-Prevention and “Undetectable = Untransmittable”: A Systematic Review

2021 ◽  
Author(s):  
Jacob Bor ◽  
Charlie Fischer ◽  
Mirva Modi ◽  
Bruce Richman ◽  
Cameron Kinker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Viral Suppression ◽  
Hiv Treatment ◽  
Treatment As Prevention ◽  
Global Literature ◽  
Knowledge And Attitudes ◽  
Positive Attitudes ◽  
The World ◽  
Hiv Treatment As Prevention ◽  
Changing Knowledge

AbstractPeople on HIV treatment with undetectable virus cannot transmit HIV sexually (Undetectable = Untransmittable, U = U). However, the science of treatment-as-prevention (TasP) may not be widely understood by people with and without HIV who could benefit from this information. We systematically reviewed the global literature on knowledge and attitudes related to TasP and interventions providing TasP or U = U information. We included studies of providers, patients, and communities from all regions of the world, published 2008–2020. We screened 885 papers and abstracts and identified 72 for inclusion. Studies in high-income settings reported high awareness of TasP but gaps in knowledge about the likelihood of transmission with undetectable HIV. Greater knowledge was associated with more positive attitudes towards TasP. Extant literature shows low awareness of TasP in Africa where 2 in 3 people with HIV live. The emerging evidence on interventions delivering information on TasP suggests beneficial impacts on knowledge, stigma, HIV testing, and viral suppression.Review was pre-registered at PROSPERO: CRD42020153725

Generalizability and scalability of HIV ‘treatment as prevention’

AIDS ◽  
2013 ◽  
Vol 27 (15) ◽  
pp. 2493-2494
Author(s):  
Kathryn E. Lancaster ◽  
Nadia Nguyen ◽  
Catherine R. Lesko ◽  
Kimberly A. Powers
Keyword(s):  
Hiv Treatment ◽  
Treatment As Prevention ◽  
Hiv Treatment As Prevention
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