Long-term outcome and determinants of event-free survival in patients treated with balloon angioplasty for in-stent restenosis

1999 ◽  
Vol 83 (8) ◽  
pp. 1268-1270 ◽  
Author(s):  
Fernando Alfonso ◽  
Marı́a J Pérez-Vizcayno ◽  
Rosana Hernández ◽  
Javier Goicolea ◽  
Antonio Fernández-Ortı́z ◽  
...  
Keyword(s):  
Balloon Angioplasty ◽  
Event Free Survival ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
Stent Restenosis ◽  
In Stent Restenosis

scholarly journals OP0146 LONG TERM OUTCOME AND PROGNOSIS FACTORS OF ISOLATED AORTITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 93.1-93
Author(s):  
Y. Ferfar ◽  
S. Morinet ◽  
O. Espitia ◽  
C. Agard ◽  
M. Vautier ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Giant Cell Arteritis ◽  
Takayasu Arteritis ◽  
Vascular Complications ◽  
Event Free Survival ◽  
Prognosis Factors ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival

Background:Aortitis is a group of disorders characterized by the inflammation of the aorta. The most common causes of aortitis are the large-vessel vasculitis i.e. giant cell arteritis (GCA) and Takayasu arteritis (TA). However, aortitis may be isolated. Because of the wide variation in the course of aortitis, predicting outcome is challenging. The optimal management strategy of isolated aortitis (IA) is still unclear as IA is poorly defined, with data consisting of small retrospective and case control studies.Objectives:To assess the long-term outcome and prognosis factors for vascular complications in patients with isolated aortitis.Methods:Retrospective multicenter study of 353 patients with non-infectious aortitis including 136 giant cell arteritis (GCA), 96 Takayasu arteritis (TA) and 73 isolated aortitis (IA). Factors associated with event-free survival, vascular event-free survival and revascularization-free survival were assessed. Risk factors for vascular complications were identified in multivariate analysis.Results:After a median follow up of 52 months, vascular complications were observed in 32.3 %, revascularization in 30 % and death in 7.6%. The 5-year cumulative incidence of vascular complications was 58% (41; 71), 20% (13; 29), and 19 % (11; 28) in IA, GCA and TA, respectively. In multivariate analysis, IA [HR, 1.85 (1.19 to 2.88), p=0.017] and male gender [1.77 (1.26 to 2.49), p<0.0001] were independently associated with vascular events. The 5-year surgery-free survival was 45% (31; 65), 71% (62; 81) and 76% (68; 86) in IA, TA and GCA, respectively.Conclusion:IA has a worse vascular prognosis than GCA and TA. Sixty percent of IA patients will experience a vascular complication within 5 years from diagnosis.Disclosure of Interests:None declared

scholarly journals Long-Term Outcome of Monochorionic Twins after Fetoscopic Laser Therapy Compared to Matched Dichorionic Twins

2020 ◽  
Vol 47 (12) ◽  
pp. 947-954
Author(s):  
Ladina Rüegg ◽  
Margaret Hüsler ◽  
Franziska Krähenmann ◽  
Roland Zimmermann ◽  
Giancarlo Natalucci ◽  
...  
Keyword(s):  
Birth Weight ◽  
Free Time ◽  
Control Group ◽  
Event Free Survival ◽  
Monochorionic Twins ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
School Career

<b><i>Introduction:</i></b> The only causal therapy is fetoscopic laser surgery (FLS). The aims of this study were to analyze the long-term outcome of monochorionic twins treated by FLS, including their school career, need for therapy and special aid equipment, and free-time activities, and compare their outcome to matched dichorionic twins. <b><i>Material and Methods:</i></b> Among the 57 women treated at a single fetal treatment center between 2008 and 2017 with FLS because of twin-to-twin transfusion syndrome, 25 women with 42 children were included in the FLS group. The control group consisted of 16 dichorionic twin pairs matched for birth year, gestational age (GA), birth weight, and sex. The long-term outcome was assessed by a parental questionnaire and a standardized neurodevelopmental examination for children born before 32 gestational weeks or with a birth weight lower than 1500 g. They were also registered into the Swiss Neonatal Network database. The primary outcome was event-free survival, defined as normal neurology, behavior, vision, and hearing. The secondary outcomes were school career, need for therapy and special aid equipment, and free-time activities. <b><i>Results:</i></b> An event-free survival was found in 32 children (76%) in the laser and in 24 children (75%) in the control group (<i>p</i> = 0.91). Neurological anomalies were found in 5 children (12%) in the laser group and 3 children (9%) in the control group (<i>p</i> = 1.00). Multiple logistic regression analysis showed that GA at delivery was the only predictive factor for event-free survival. There were no significant differences regarding school career, therapies, or special aid equipment between the 2 groups. We found that children without FLS were involved in more free-time activities and needed fewer breaks during physical activity than children with FLS during pregnancy. <b><i>Conclusion:</i></b> The outcome of monochorionic twins treated with FLS is comparable to the outcome of dichorionic twins. Long-term neurodevelopment in the cohort was mainly dependent on GA at birth.

Long‐term outcome of brachytherapy treatment for coronary in‐stent restenosis: Ten‐year follow‐up

2018 ◽  
Vol 93 (4) ◽  
pp. E211-E216
Author(s):  
Hiroko Nakahama ◽  
Michelle Jankowski ◽  
Simon R. Dixon ◽  
Amr E. Abbas
Keyword(s):  
Term Outcome ◽  
Long Term Outcome ◽  
Stent Restenosis ◽  
In Stent Restenosis

The adaptive immune system and long-term outcome in patients with stable coronary disease

2005 ◽  
Vol 93 (02) ◽  
pp. 257-260 ◽  
Author(s):  
Senta Graf ◽  
Mariam Nikfardjam ◽  
Stephan Lehr ◽  
Gerald Maurer ◽  
Johann Wojta ◽  
...  
Keyword(s):  
Immune System ◽  
Relative Risk ◽  
Cox Regression ◽  
Adaptive Immune System ◽  
Event Free Survival ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
Adaptive Immune

SummaryComponents of the adaptive immune system, in particular lymphocytes and immunoglobulin, play a major role in advanced atherosclerotic lesions. We sought to determine whether routine measurements of the relative number of circulating lymphocytes (%L) and γ -globulin (%G) reflecting immunoglobulin are related to event-free survival in patients with stable coronary artery disease (CAD). We prospectively studied the combined endpoint all-cause mortality, myocardial infarction and coronary revascularization procedures in 141 patients after successful percutaneous coronary intervention during a median follow-up time of 13.2 years. Using Cox regression, we found a significant influence of %L on event-free survival (P = 0.007) with a relative risk of 2.21 comparing third to first tertile. Subjects with higher %G values likewise had a shorter event-free survival (P = 0.008) with a relative risk of 1.67 comparing third to first tertile. The predictive value of %L and %G remained significant after adjustment for demographic data, cardiovascular risk factors, extent of CAD and other inflammatory markers. We conclude that the fraction of γ -globulin and in particular the relative lymphocyte cell count may serve as readily available and reliable prognostic tools for the long-term outcome in patients with stable CAD.

scholarly journals The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Vladimír Kincl ◽  
Jan Máchal ◽  
Adéla Drozdová ◽  
Roman Panovský ◽  
Anna Vašků
Keyword(s):  
Cox Regression ◽  
Event Free Survival ◽  
Heart Failure Hospitalization ◽  
Prognostic Information ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
Vessel Disease ◽  
Artery Disease

Aim. The purpose of this study is to determine the association between eotaxin 426 C/T, −384 A/G, 67 G/A, eNOS −786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD.Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation.Results. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin −384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35–5.85),p=0.006; HR (95% CI) 2.63 (1.19–5.83),p=0.017; eotaxin −384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease.Conclusion. The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.

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