Expression of MBP-HCV NS1/E2 fusion protein in E. coli and detection of anti-NS1/E2 antibody in type c chronic liver disease

1992 ◽  
Vol 183 (3) ◽  
pp. 925-930 ◽  
Author(s):  
Eiji Mita ◽  
Norio Hayashi ◽  
Keiji Ueda ◽  
Akinori Kasahara ◽  
Hideyuki Fusamoto ◽  
...  
2020 ◽  
pp. 3080-3089
Author(s):  
Paul K. Middleton ◽  
Debbie L. Shawcross

Hepatic encephalopathy (HE) is a significant complication of both acute and chronic liver disease, causing much morbidity and mortality. It is a complex neuropsychological condition, associated with hyperammonaemia and systemic inflammation, with a wide spectrum of symptoms. The West Haven criteria describe grades of severity from 0 (subclinical) and I (changes in awareness, mood, attention, cognition, and sleep pattern) through to IV (coma). It is further classified by the underlying aetiology: type A, due to acute liver failure; type B, secondary to portosystemic shunting; and type C, occurring in chronic liver disease in association with precipitating factors including infections, gastrointestinal bleeding, and electrolyte disorders, particularly hyponatraemia. There is no definitive test or set of diagnostic criteria to establish a diagnosis of HE, which remains primarily a clinical diagnosis of exclusion in patients with a history or clinical evidence of liver disease. Management depends on the type of HE, but for type C (the commonest type) typically includes lactulose and rifaximin. Patients with cirrhosis with ongoing overt HE despite optimal medical management have a dismal outlook and should be considered promptly for liver transplantation.


1992 ◽  
Vol 27 (5) ◽  
pp. 617-623 ◽  
Author(s):  
Toshihiko Doi ◽  
Gotaro Yamada ◽  
Hisashi Endo ◽  
Hiroshi Nishimoto ◽  
Michiko Takahashi ◽  
...  

1996 ◽  
Vol 47 (1-2) ◽  
pp. 122
Author(s):  
Toyoki Moribe ◽  
Sayaka Nakatani ◽  
Toshihiko Kaneshige ◽  
Noriyoshi Kuzushita ◽  
Kazuhiro Katayama ◽  
...  

Hepatology ◽  
1995 ◽  
Vol 22 (2) ◽  
pp. 407-412 ◽  
Author(s):  
Masafumi Naito ◽  
Norio Hayashi ◽  
Toyoki Moribe ◽  
Hideki Hagiwara ◽  
Eiji Mita ◽  
...  

1996 ◽  
Vol 23 (4) ◽  
pp. 280-283 ◽  
Author(s):  
Jia-Horng Kao ◽  
Ming-Yang Lai ◽  
Pei-Jer Chen ◽  
Lih-Hwa Hwang ◽  
Ding-Shinn Chen

Kanzo ◽  
1997 ◽  
Vol 38 (10) ◽  
pp. 587-595 ◽  
Author(s):  
Shunichi FUKUHARA ◽  
Kunihiko HINO ◽  
Koji KATO ◽  
Eiichi TOMITA ◽  
Shiro YUASA ◽  
...  

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