Kinetics and Mechanism of Dissociation of Zinc Ion from Carbonic Anhydrase

1978 ◽  
Vol 9 (3) ◽  
pp. 217-229 ◽  
Author(s):  
Alice Y. Romans ◽  
Mary E. Graichen ◽  
C.H. Lochmuller ◽  
Robert W. Henkens
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Ion ◽  
Kinetics And Mechanism

Kinetics and mechanism of anionic ligand binding to carbonic anhydrase

1987 ◽  
Vol 26 (2-3) ◽  
pp. 217-224 ◽  
Author(s):  
Bala S. Prabhananda ◽  
Edgar Rittger ◽  
Ernst Grell
Keyword(s):  
Carbonic Anhydrase ◽  
Ligand Binding ◽  
Kinetics And Mechanism ◽  
Anionic Ligand

scholarly journals Kinetics and Mechanism of Decarboxylation of Hydrogen Carbonate Coordinated to a Macrocyclic Chromium(III) Complex. A Comparison with the Carbonic Anhydrase Enzymes.

1992 ◽  
Vol 46 ◽  
pp. 521-526 ◽  
Author(s):  
J. Eriksen ◽  
L. Mønsted ◽  
O. Mønsted ◽  
Abdel Moneim El-Torgoman ◽  
Frits Abildgaard ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Kinetics And Mechanism ◽  
Hydrogen Carbonate

Kinetics and Mechanism of Carbonic Anhydrase Isoenzymes

1984 ◽  
Vol 429 (1 Biology and C) ◽  
pp. 61-75 ◽  
Author(s):  
SVEN LINDSKOG ◽  
PAUL ENGBERG ◽  
CECILIA FORSMAN ◽  
SIRAG A. IBRAHIM ◽  
BENGT-HARALD JONSSON ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Kinetics And Mechanism

scholarly journals Synthesis and Evaluation of New Phthalazine Urea and Thiourea Derivatives as Carbonic Anhydrase Inhibitors

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Nurcan Berber ◽  
Mustafa Arslan ◽  
Emre Yavuz ◽  
Cigdem Bilen ◽  
Nahit Gencer
Keyword(s):  
Carbonic Anhydrase ◽  
Nitro Group ◽  
Zinc Ion ◽  
Inhibitory Effect ◽  
Carbonic Anhydrases ◽  
Coumarin Derivatives ◽  
Inhibitory Effects ◽  
Carbonic Anhydrase Inhibitors ◽  
Thiourea Derivatives ◽  
Amine Derivative

A new series of phthalazine substituted urea and thiourea derivatives were synthesized, and their inhibitory effects on the activity of purified human carbonic anhydrases (hCAs I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative(1)was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and nitro group was reduced to amine derivative(2)with SnCl2·2H2O. The compound was reacted with isocyanates and isothiocyanates to get the final products(3a–p). The results showed that all the synthesized compounds inhibited the CA isoenzymes activity.3a(IC50= 6.40 µM for hCA I and 6.13 µM for hCA II) has the most inhibitory effect. The synthesized compounds are very bulky to be able to bind near the zinc ion, and they much more probably bind as the coumarin derivatives.

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

2018 ◽  
Vol 54 (73) ◽  
pp. 10312-10315 ◽  
Author(s):  
Giuseppina De Simone ◽  
Andrea Angeli ◽  
Murat Bozdag ◽  
Claudiu T. Supuran ◽  
Jean-Yves Winum ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Mode ◽  
Zinc Ion ◽  
Carbonic Anhydrases ◽  
Carbonic Anhydrase Inhibitors ◽  
Lead Compounds ◽  
Substrate Analog ◽  
Catalytic Zinc

N-Unsubstituted carbamates can be used as lead compounds for the development of carbonic anhydrase inhibitors possessing a binding mode similar to bicarbonate.

Carbonic Anhydrase: An Example of How the Cavity Governs the Reactivity at the Zinc Ion

1995 ◽  
Vol 17 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Ivano Bertini ◽  
Claudio Luchinat ◽  
Stefano Mangani ◽  
Roberta Pierattelli
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Ion
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