Clinical and immunological responses of ewes following vaccination with an experimental formalin-inactivated Chlamydia psittaci (ovis) vaccine and subsequent challenge with the live organism during pregnancy

1990 ◽  
Vol 146 (4) ◽  
pp. 341-348 ◽  
Author(s):  
A.J. Wilsmore ◽  
B.C. Wilsmore ◽  
G.J.R. Dagnall ◽  
K.A. Izzard ◽  
R.M. Woodland ◽  
...  
Keyword(s):  
Chlamydia Psittaci ◽  
Immunological Responses ◽  
Subsequent Challenge ◽  
Live Organism

Ultrastructural Studies on Genital Infection with the Chlamydial Agent of Guinea Pig Inclusion Conjunctivitis

1977 ◽  
Vol 35 ◽  
pp. 352-353
Author(s):  
B. L. Soloff ◽  
A. L. Barron ◽  
H. J. White ◽  
R. G. Rank
Keyword(s):  
Guinea Pig ◽  
Sexual Contact ◽  
Chlamydia Psittaci ◽  
Genital Infection ◽  
Major Site ◽  
Ultrastructural Studies ◽  
Tissue Specimens ◽  
Guinea Pig Model ◽  
Adequate Tissue ◽  
Genital Tissue

Chlamydial organisms (specifically C. trachomatis) have been implicated as a frequent cause of genital infection in the human (1). Study of the histo- pathological aspects of such infections has been impeded because of difficulties in obtaining adequate tissue specimens and the lack of a suitable experimental host. In 1964, Murray (2) isolated the causative agent of guinea pig inclusion conjunctivitis which possesses similarities to human inclusion conjunctivitis. This guinea pig organism was found to be a member of the Chlamydia psittaci subgroup and was designated as the Gp-ic agent. Male guinea pigs have been successfully infected with Gp-ic by intraurethral inoculation. Transmission of the infection to the female by sexual contact has been demonstrated (3). We are not aware of any ultrastructural studies to date concerning the development of this agent in genital tissue.Studies in our laboratory have established that, in our guinea pig model, the cervix is the major site of injection.

Der Einfluss einer Behandlung mit Doxyzyklin auf den Verlauf einer experimentellen Chlamydia psittaci Infektion beim Kalb

Pneumologie ◽  
2013 ◽  
Vol 67 (06) ◽  
Author(s):  
A Prohl ◽  
C Ostermann ◽  
M Lohr ◽  
A Berndt ◽  
E Liebler-Tenorio ◽  
...  
Keyword(s):  
Chlamydia Psittaci

Die Behandlung einer experimentellen respiratorischen Chlamydia psittaci Infektion beim Kalb mit Enrofloxacin ± Rifampicin

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
A Prohl ◽  
M Lohr ◽  
C Ostermann ◽  
A Berndt ◽  
E Liebler-Tenorio ◽  
...  
Keyword(s):  
Chlamydia Psittaci

scholarly journals Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung

2021 ◽  
Vol 18 (1) ◽  
pp. 61-73
Author(s):  
Leonor de Braganca ◽  
G. John Ferguson ◽  
Jose Luis Santos ◽  
Jeremy P. Derrick
Keyword(s):  
Delivery Systems ◽  
Immunological Responses ◽  
Viral Nanoparticle

scholarly journals Gut microbiota modulation induced by Zika virus infection in immunocompetent mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rafael Corrêa ◽  
Igor de Oliveira Santos ◽  
Heloísa Antoniella Braz-de-Melo ◽  
Lívia Pimentel de Sant’Ana ◽  
Raquel das Neves Almeida ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Gut Microbiome ◽  
Zika Virus ◽  
Hypervariable Region ◽  
Microbiota Composition ◽  
Colon Tissue ◽  
Zikv Infection ◽  
Immunological Responses ◽  
Immunocompetent Mice ◽  
Gut Microbiota Composition

AbstractGut microbiota composition can modulate neuroendocrine function, inflammation, and cellular and immunological responses against different pathogens, including viruses. Zika virus (ZIKV) can infect adult immunocompetent individuals and trigger brain damage and antiviral responses. However, it is not known whether ZIKV infection could impact the gut microbiome from adult immunocompetent mice. Here, we investigated modifications induced by ZIKV infection in the gut microbiome of immunocompetent C57BL/6J mice. Adult C57BL/6J mice were infected with ZIKV and the gut microbiota composition was analyzed by next-generation sequencing of the V4 hypervariable region present in the bacterial 16S rDNA gene. Our data showed that ZIKV infection triggered a significant decrease in the bacteria belonging to Actinobacteria and Firmicutes phyla, and increased Deferribacteres and Spirochaetes phyla components compared to uninfected mice. Interestingly, ZIKV infection triggered a significant increase in the abundance of bacteria from the Spirochaetaceae family in the gut microbiota. Lastly, we demonstrated that modulation of microbiota induced by ZIKV infection may lead to intestinal epithelium damage and intense leukocyte recruitment to the intestinal mucosa. Taken together, our data demonstrate that ZIKV infection can impact the gut microbiota composition and colon tissue homeostasis in adult immunocompetent mice.

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