Die Behandlung einer experimentellen respiratorischen Chlamydia psittaci Infektion beim Kalb mit Enrofloxacin ± Rifampicin

Chlamydial organisms (specifically C. trachomatis) have been implicated as a frequent cause of genital infection in the human (1). Study of the histo- pathological aspects of such infections has been impeded because of difficulties in obtaining adequate tissue specimens and the lack of a suitable experimental host. In 1964, Murray (2) isolated the causative agent of guinea pig inclusion conjunctivitis which possesses similarities to human inclusion conjunctivitis. This guinea pig organism was found to be a member of the Chlamydia psittaci subgroup and was designated as the Gp-ic agent. Male guinea pigs have been successfully infected with Gp-ic by intraurethral inoculation. Transmission of the infection to the female by sexual contact has been demonstrated (3). We are not aware of any ultrastructural studies to date concerning the development of this agent in genital tissue.Studies in our laboratory have established that, in our guinea pig model, the cervix is the major site of injection.

Download Full-text

Der Einfluss einer Behandlung mit Doxyzyklin auf den Verlauf einer experimentellen Chlamydia psittaci Infektion beim Kalb

Pneumologie ◽

10.1055/s-0033-1343975 ◽

2013 ◽

Vol 67 (06) ◽

Author(s):

A Prohl ◽

C Ostermann ◽

M Lohr ◽

A Berndt ◽

E Liebler-Tenorio ◽

...

Keyword(s):

Chlamydia Psittaci

Download Full-text

Faculty Opinions recommendation of Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718359715.793538725 ◽

2017 ◽

Author(s):

Fabienne Paumet ◽

Jordan Wesolowski

Keyword(s):

Membrane Protein ◽

Chlamydia Psittaci ◽

Host Protein ◽

Inclusion Membrane

Download Full-text

Ultrastructural studies of Chlamydia psittaci 6BC variant strains. I. Ultrastructure of the surface layers of egg-passaged 6BC strain

Canadian Journal of Microbiology ◽

10.1139/m73-142 ◽

1973 ◽

Vol 19 (8) ◽

pp. 887-894

Author(s):

Linda Poffenroth ◽

J. W. Costerton ◽

Nonna Kordová ◽

John C. Wilt

Keyword(s):

Chick Embryo ◽

Microscopic Examination ◽

Electron Microscopic Examination ◽

Chlamydia Psittaci ◽

Gram Negative Bacteria ◽

Surface Layers ◽

Electron Microscopic ◽

Gram Negative ◽

Ultrastructural Studies ◽

First Time

Electron microscopic examination of a semipurified Chlamydia psittaci 6BC strain attenuated in chick embryo yolk sac revealed for the first time two morphologically distinct small elementary bodies which differ both in the ultrastructure of their surface layers and in their buoyant densities in sucrose gradients. Also, the morphology of the surface layers of the larger reticulate forms in cell-free systems is described for the first time. Many points of difference between the surface envelopes and internal structure of chlamydial particles and those of Gram-negative bacteria are discussed.

Download Full-text

Serological Observations on Chlamydia Psittaci Infection in Finnish Dairy Herds

Acta Veterinaria Scandinavica ◽

10.1186/bf03547200 ◽

1981 ◽

Vol 22 (1) ◽

pp. 1-8

Author(s):

Erkki Neuvonen ◽

Erkki Pyörälä

Keyword(s):

Chlamydia Psittaci ◽

Dairy Herds

Download Full-text

Investigation of Lethal Concurrent Outbreak of Chlamydiosis and Pigeon Circovirus in a Zoo

Animals ◽

10.3390/ani11061654 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1654

Author(s):

Wei-Tao Chen ◽

Chin-Ann Teng ◽

Cheng-Hsin Shih ◽

Wei-Hsiang Huang ◽

Yi-Fan Jiang ◽

...

Keyword(s):

Disease Outbreaks ◽

Chlamydia Psittaci ◽

Bursa Of Fabricius ◽

Chain Reactions ◽

Renal Epithelium ◽

Polymerase Chain Reactions ◽

Transmission Electron ◽

Intracytoplasmic Inclusion Bodies ◽

Polymerase Chain ◽

Streptopelia Orientalis

During the spring, an outbreak of sudden death involving 58 birds occurred in a zoo. Histopathological examinations revealed variable numbers of intracytoplasmic basophilic microorganisms in the macrophages, hepatocytes, and renal epithelium of most birds, along with occasional botryoid intracytoplasmic inclusion bodies within histiocytes in the bursa of Fabricius. Based on the results of histopathological examinations, immunohistochemical staining, transmission electron microscopy, and polymerase chain reactions, genotype B Chlamydia psittaci infection concurrent with pigeon circovirus (PiCV) was diagnosed. A retrospective survey, including two years before the outbreak and the outbreak year, of C. psittaci and PiCV infections of dead birds in the aviaries, revealed that the outbreak was an independent episode. The findings of this study indicate that concurrent infection with C. psittaci and PiCV might lead to lethal outbreaks of chlamydiosis, particularly Streptopelia orientalis. In addition, persistently monitoring both pathogens and identifying potential PiCV carriers or transmitters might also help prevent lethal disease outbreaks.

Download Full-text

Diagnostic performance of four SARS-CoV-2 antibody assays in patients with COVID-19 or with bacterial and non-SARS-CoV-2 viral respiratory infections

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/s10096-021-04285-4 ◽

2021 ◽

Author(s):

Timo Huber ◽

Philipp Steininger ◽

Pascal Irrgang ◽

Klaus Korn ◽

Matthias Tenbusch ◽

...

Keyword(s):

Legionella Pneumophila ◽

False Positive ◽

Bacterial Infections ◽

Viral Infections ◽

Respiratory Infections ◽

Chlamydia Psittaci ◽

Specific Flow ◽

Antibody Assays ◽

Positive Results ◽

Viral Respiratory

AbstractSARS-CoV-2 antibody assays are used for epidemiological studies and for the assessment of vaccine responses in highly vulnerable patients. So far, data on cross-reactivity of SARS-CoV-2 antibody assays is limited. Here, we compared four enzyme-linked immunosorbent assays (ELISAs; Vircell SARS-CoV-2 IgM/IgA and IgG, Euroimmun SARS-CoV-2 IgA and IgG) for detection of anti-SARS-CoV-2 antibodies in 207 patients with COVID-19, 178 patients with serological evidence of different bacterial infections, 107 patients with confirmed viral respiratory disease, and 80 controls from the pre-COVID-19 era. In COVID-19 patients, the assays showed highest sensitivity in week 3 (Vircell-IgM/A and Euroimmun-IgA: 78.9% each) and after week 7 (Vircell-IgG: 97.9%; Euroimmun-IgG: 92.1%). The antibody indices were higher in patients with fatal disease. In general, IgM/IgA assays had only limited or no benefit over IgG assays. In patients with non-SARS-CoV-2 respiratory infections, IgG assays were more specific than IgM/IgA assays, and bacterial infections were associated with more false-positive results than viral infections. The specificities in bacterial and viral infections were 68.0 and 81.3% (Vircell-IgM/IgA), 84.8 and 96.3% (Euroimmun-IgA), 97.8 and 86.0% (Vircell-IgG), and 97.8 and 99.1% (Euroimmun-IgG), respectively. Sera from patients positive for antibodies against Mycoplasma pneumoniae, Chlamydia psittaci, and Legionella pneumophila yielded particularly high rates of unspecific false-positive results in the IgM/IgA assays, which was revealed by applying a highly specific flow-cytometric assay using HEK 293 T cells expressing the SARS-CoV-2 spike protein. Positive results obtained with anti-SARS-CoV-2 IgM/IgA ELISAs require careful interpretation, especially if there is evidence for prior bacterial respiratory infections.

Download Full-text