Development of an ELISA for the detection of serum chromogranin A (CgA) in prostate and non-neuroendocrine carcinomas

Gastric neuroendocrine carcinomas are rare and have a poor prognosis, and the diagnostic criteria for this disease have recently changed. We herein report a case of sporadic gastric neuroendocrine carcinoma. A 75-year-old man was referred to our hospital with epigastric pain. Endoscopic examination revealed a localized ulcerative lesion (diameter, 4 cm) at the upper stomach. The diagnosis on biopsy was neuroendocrine carcinoma. Total gastrectomy with D2 lymphadenectomy, splenectomy, and cholecystectomy was performed. Pathologically, the tumor infiltrated the subserosal layer, and 6/49 lymph nodes were involved. The tumor was uniform in shape and arranged in a rosette-like structure to form solid nests, with medium-sized, round-to-cuboid-shaped tumor cells and intense mitosis 46/10 HPF. It was positive for synaptophysin and chromogranin A, and the Ki-67 labeling index was 70–80%. The diagnosis of neuroendocrine carcinoma was made according to the WHO 2010 criteria. The patient was followed up for three years without recurrence.

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Neuroendocrine neoplasms of the pancreas: diagnosis and pitfalls

Virchows Archiv ◽

10.1007/s00428-021-03211-5 ◽

2021 ◽

Author(s):

Björn Konukiewitz ◽

Moritz Jesinghaus ◽

Atsuko Kasajima ◽

Günter Klöppel

Keyword(s):

Neuroendocrine Tumors ◽

Chromogranin A ◽

Molecular Profile ◽

Neuroendocrine Neoplasms ◽

Histological Differentiation ◽

Pancreatic Neuroendocrine Neoplasms ◽

Poorly Differentiated ◽

Well Differentiated ◽

Diagnostic Pitfalls ◽

Neuroendocrine Carcinomas

AbstractCommon to neuroendocrine neoplasms of the pancreas is their expression of synaptophysin, chromogranin A, and/or INSM1. They differ, however, in their histological differentiation and molecular profile. Three groups can be distinguished: well-differentiated neuroendocrine neoplasms (neuroendocrine tumors), poorly differentiated neuroendocrine neoplasms (neuroendocrine carcinomas), and mixed neuroendocrine-non-neuroendocrine neoplasms. However, the expression of synaptophysin and, to a lesser extent, also chromogranin A is not restricted to the neuroendocrine neoplasms, but may also be in a subset of non-neuroendocrine epithelial and non-epithelial neoplasms. This review provides the essential criteria for the diagnosis of pancreatic neuroendocrine neoplasms including diagnostic clues for the distinction of high-grade neuroendocrine tumors from neuroendocrine carcinomas and an algorithm avoiding diagnostic pitfalls in the delineation of non-neuroendocrine neoplasms with neuroendocrine features from pancreatic neuroendocrine neoplasms.

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High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(01)00149-6 ◽

2002 ◽

Vol 9 (1) ◽

pp. 32-36 ◽

Cited By ~ 1

Author(s):

P Florio

Keyword(s):

Amniotic Fluid ◽

Umbilical Cord ◽

Chromogranin A ◽

Cord Plasma

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Abstract #805732: Duodenal Neuroendocrine Tumor with Liver Metastasis with High Circulating Levels of Calcitonin and Negative Octreoscan and Normal Chromogranin-A

Endocrine Practice ◽

10.1016/s1530-891x(20)39641-5 ◽

2020 ◽

Vol 26 ◽

pp. 216-217

Author(s):

Jose Paz-Ibarra

Keyword(s):

Liver Metastasis ◽

Neuroendocrine Tumor ◽

Chromogranin A ◽

Circulating Levels

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Diarrhöen, Übelkeit und Erbrechen

Praxis ◽

10.1024/1661-8157.98.25.1535 ◽

2009 ◽

Vol 98 (25) ◽

pp. 1535-1538

Author(s):

Senkel ◽

Fischer-Lampsatis

Keyword(s):

Chromogranin A ◽

Übelkeit Und Erbrechen

Ein 54-jähriger Patient, der bereits mehrfach wegen diverser Ulzerationen mit Blutungskomplikationen in Behandlung war, stellte sich mit Übelkeit und Erbrechen sowie Diarrhöen vor. Seit Jahren bestanden zudem rezidivierende Durchfälle. Laborchemisch war bereits einmal der V.a. einen neuroendokrinen Tumor gestellt worden, der sich dann aber intraoperativ nicht bestätigt hatte. Bei nach wie vor bestehendem Verdacht und erhöhten Chromogranin-A-Werten sowie erhöhtem Gastrinspiegel wurde eine Somatostatinrezeptor-Szintigraphie durchgeführt, in der sich ein Herd zeigte, der sich schliesslich als Metastase eines Gastrinoms unklarer Lokalisation identifizieren liess.

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