Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor

1998 ◽  
Vol 355 (2-3) ◽  
pp. 267-274 ◽  
Author(s):  
Pascaline Barbier ◽  
Antonella Colelli ◽  
M.Laura Bolognesi ◽  
Anna Minarini ◽  
Vincenzo Tumiatti ◽  
...  
Keyword(s):  
Binding Profile ◽  
Antagonist Binding

scholarly journals The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced AmyloidβBinding Antibodies on Cynomolgus Monkeys and Guinea Pigs

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Akira Yano ◽  
Kaori Ito ◽  
Yoshikatsu Miwa ◽  
Yoshito Kanazawa ◽  
Akiko Chiba ◽  
...  
Keyword(s):  
Immune Responses ◽  
Tetanus Toxoid ◽  
Guinea Pigs ◽  
Peptide Vaccine ◽  
Cell Epitope ◽  
T Cell Epitope ◽  
Peptide Vaccination ◽  
Binding Profile ◽  
Cynomolgus Monkeys ◽  
The Brain

The reduction of brain amyloid beta (Aβ) peptides by anti-Aβantibodies is one of the possible therapies for Alzheimer’s disease. We previously reported that the Aβpeptide vaccine including the T-cell epitope of diphtheria-tetanus combined toxoid (DT) induced anti-Aβantibodies, and the prior immunization with conventional DT vaccine enhanced the immunogenicity of the peptide. Cynomolgus monkeys were given the peptide vaccine subcutaneously in combination with the prior DT vaccination. Vaccination with a similar regimen was also performed on guinea pigs. The peptide vaccine induced anti-Aβantibodies in cynomolgus monkeys and guinea pigs without chemical adjuvants, and excessive immune responses were not observed. Those antibodies could preferentially recognize Aβ40, and Aβ42compared to Aβfibrils. The levels of serum anti-Aβantibodies and plasma Aβpeptides increased in both animals and decreased the brain Aβ40level of guinea pigs. The peptide vaccine could induce a similar binding profile of anti-Aβantibodies in cynomolgus monkeys and guinea pigs. The peptide vaccination could be expected to reduce the brain Aβpeptides and their toxic effects via clearance of Aβpeptides by generated antibodies.

Discovery and Mapping of an Intracellular Antagonist Binding Site at the Chemokine Receptor CCR2

2014 ◽  
Vol 86 (4) ◽  
pp. 358-368 ◽  
Author(s):  
Annelien J.M. Zweemer ◽  
Julia Bunnik ◽  
Margo Veenhuizen ◽  
Fabiana Miraglia ◽  
Eelke B. Lenselink ◽  
...  
Keyword(s):  
Binding Site ◽  
Chemokine Receptor ◽  
Antagonist Binding ◽  
Chemokine Receptor Ccr2

scholarly journals Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality

2018 ◽  
Vol 15 (3) ◽  
pp. 1062-1072 ◽  
Author(s):  
Candy S. Hwang ◽  
Paul T. Bremer ◽  
Cody J. Wenthur ◽  
Sam On Ho ◽  
SuMing Chiang ◽  
...  
Keyword(s):  
Binding Profile ◽  
Opioid Binding

Ligand Binding Profile and Effects of Melanin-Concentrating Hormone on Fish and Mammalian Skin Cells

2006 ◽  
Vol 885 (1) ◽  
pp. 455-458 ◽  
Author(s):  
T. SUPLY ◽  
B. CARDINAUD ◽  
S. KANAMORI ◽  
C. DAL FARRRA ◽  
S. RICOIS ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Binding Profile ◽  
Skin Cells ◽  
Mammalian Skin ◽  
Melanin Concentrating Hormone
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