scholarly journals Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages

FEBS Letters ◽  
1999 ◽  
Vol 453 (1-2) ◽  
pp. 129-134 ◽  
Author(s):  
Felipe Herencia ◽  
M.Luisa Ferrándiz ◽  
Amalia Ubeda ◽  
Isabel Guillén ◽  
José N. Dominguez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Peritoneal Macrophages ◽  
Cyclooxygenase 2 ◽  
Chalcone Derivatives ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Mouse Peritoneal Macrophages

scholarly journals Effect of Kramecyne on the Inflammatory Response in Lipopolysaccharide-Stimulated Peritoneal Macrophages

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
E. Sánchez-Miranda ◽  
J. Lemus-Bautista ◽  
S. Pérez ◽  
J. Pérez-Ramos
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Peritoneal Macrophages ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
North And South America ◽  
North And South ◽  
Mouse Peritoneal Macrophages ◽  
Necrosis Factor

Kramecyne is a new peroxide, it was isolated fromKrameria cytisoides, methanol extract, and this plant was mostly found in North and South America. This compound showed potent anti-inflammatory activity; however, the mechanisms by which this compound exerts its anti-inflammatory effect are not well understood. In this study, we examined the effects of kramecyne on inflammatory responses in mouse lipopolysaccharide- (LPS-) induced peritoneal macrophages. Our findings indicate that kramecyne inhibits LPS-induced production of tumor necrosis factor (TNF-α) and interleukin- (IL-) 6. During the inflammatory process, levels of cyclooxygenase- (COX-) 2, nitric oxide synthase (iNOS), and nitric oxide (NO) increased in mouse peritoneal macrophages; however, kramecyne suppressed them significantly. These results provide novel insights into the anti-inflammatory actions and support its potential use in the treatment of inflammatory diseases.

scholarly journals Induction of Nitric Oxide Synthase by Oldenlandia diffusa in Mouse Peritoneal Macrophages

2002 ◽  
Vol 25 (9) ◽  
pp. 1142-1146 ◽  
Author(s):  
Hwan-Suck Chung ◽  
Hyun-Ja Jeong ◽  
Seung-Heon Hong ◽  
Mi-Sun Kim ◽  
So-Jin Kim ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Peritoneal Macrophages ◽  
Oxide Synthase ◽  
Mouse Peritoneal Macrophages ◽  
Oldenlandia Diffusa

A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression

2003 ◽  
Vol 368 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Patricia Fern�ndez ◽  
M. Isabel Guill�n ◽  
Amalia Ubeda ◽  
Pablo L�pez-Cremades ◽  
Enrique Aller ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cyclooxygenase 2 ◽  
Anti Inflammatory ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Activation of inducible nitric oxide synthase by Euonymus alatus in mouse peritoneal macrophages

2002 ◽  
Vol 318 (1-2) ◽  
pp. 113-120 ◽  
Author(s):  
Hwan-Suck Chung ◽  
Hyun-Ja Jeong ◽  
Jung-Soo Kim ◽  
Seung-Il Jeong ◽  
Kyung-Soo Kim ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Peritoneal Macrophages ◽  
Euonymus Alatus ◽  
Oxide Synthase ◽  
Mouse Peritoneal Macrophages ◽  
Inducible Nitric Oxide
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