scholarly journals Jirasek, Jan E. An Atlas of the Human Embryo and Fetus. A Photographic Review of Human Prenatal Development. The Encyclopedia of Visual Medicine Series. New York and London: The Parthenon Publishing Group, 2001:1–144.

2001 ◽  
Vol 75 (6) ◽  
pp. 1249
Author(s):  
John E Buster
2006 ◽  
Vol 235 (2) ◽  
pp. 468-477 ◽  
Author(s):  
Shigehito Yamada ◽  
Chigako Uwabe ◽  
Tomoko Nakatsu-Komatsu ◽  
Yutaka Minekura ◽  
Masaji Iwakura ◽  
...  

PEDIATRICS ◽  
1989 ◽  
Vol 84 (1) ◽  
pp. A50-A50
Author(s):  
Frances P. Glascoe ◽  
William R. Moore ◽  
James Henderson ◽  
Elaine D. Martin

Leach P. Your Baby and Child: From Birth to Age Five. New York, NY: Alfred A. Knopf; 1978; list price $24.45 (#4 on the 1988 bestseller list of books on child care of the Ingram Book Co, distributors of trade books). Addressing the effects of nature and nurture on development, Leach covers prenatal development through preschool with particular attention to infancy. Parents' roles, identical for mothers and fathers, are diverse and include controller of environments, model of ideal behavior, nurturer, and instructor. Management methods involve positive reinforcement, ignoring, and active listening; designed to be preventive, corrective, and instructive. Detailed information is given about specific practices including nutrition, stimulatory activities, illness, and education. There is some consideration of environmental forces, parenting difficulties, and the needs of exceptional children. While an intact family is not presumed, material resources are, and presence of a homemaker is advised until children reach three years of age. The text is moderately difficult to read, lacks organization and cross-referencing in the indices. However, the book is supported by numerous photographs and illustrations. The medical content was rated as fair but parents are prompted to seek medical attention appropriately.


2021 ◽  
Author(s):  
Csaba Kerepesi ◽  
Bohan Zhang ◽  
Sang-Goo Lee ◽  
Alexandre Trapp ◽  
Vadim N. Gladyshev

The notion that germline cells do not age goes back to the 19th century ideas of August Weismann. However, being in a metabolically active state, they accumulate damage and other age-related changes over time, i.e., they age. For new life to begin in the same young state, they must be rejuvenated in the offspring. Here, we developed a new multi-tissue epigenetic clock and applied it, together with other aging clocks, to track changes in biological age during mouse and human prenatal development. This analysis revealed a significant decrease in biological age, i.e. rejuvenation, during early stages of embryogenesis, followed by an increase in later stages. We further found that pluripotent stem cells do not age even after extensive passaging and that the examined epigenetic age dynamics is conserved across species. Overall, this study uncovers a natural rejuvenation event during embryogenesis and suggests that the minimal biological age (the ground zero) marks the beginning of organismal aging.


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