Longitudinal Impact of WTC Dust Inhalation on Rat Cardiac Tissue Transcriptomic Profiles

First responders (FR) exposed to the World Trade Center (WTC) Ground Zero air over the first week after the 9/11 disaster have an increased heart disease incidence compared to unexposed FR and the general population. To test if WTC dusts were causative agents, rats were exposed to WTC dusts (under isoflurane [ISO] anesthesia) 2 h/day on 2 consecutive days; controls received air/ISO or air only. Hearts were collected 1, 30, 240, and 360 d post-exposure, left ventricle total RNA was extracted, and transcription profiles were obtained. The data showed that differentially expressed genes (DEG) for WTC vs. ISO rats did not reach any significance with a false discovery rate (FDR) < 0.05 at days 1, 30, and 240, indicating that the dusts did not impart effects beyond any from ISO. However, at day 360, 14 DEG with a low FDR were identified, reflecting potential long-term effects from WTC dust alone, and the majority of these DEG have been implicated as having an impact on heart functions. Furthermore, the functional gene set enrichment analysis (GSEA) data at day 360 showed that WTC dust could potentially impact the myocardial energy metabolism via PPAR signaling and heart valve development. This is the first study showing that WTC dust could significantly affect some genes that are associated with the heart/CV system, in the long term. Even > 20 years after the 9/11 disaster, this has potentially important implications for those FR exposed repeatedly at Ground Zero over the first week after the buildings collapsed.

APPLICATION OF ARTIFICIAL INTELLIGENCE (AI) TO ASSESS THE ROLE OF COVID-19 LOCKDOWN IN THE DOMAIN OF ESTUARINE ACIDIFICATION

The branch of computer science that deals with the simulation of variables with the help of a computer are termed Artificial Intelligence (AI). Here we attempt to predict the pace of acidification in the Digha coast of the Bay of Bengal based on available datasets of more than three decades. The ground zero observation on the data set reveals a decreasing trend of pH since 1984 with a sudden hike in premonsoon 2020, the period coinciding with the COVID 19 lockdown phase in the Indian sub-continent.

The Heritage Strikes Back: Athlete Activism, Black Lives Matter, and the Iconic Fifth Wave of Activism in the (W)NBA Bubble

On August 26, 2020, the sporting world experienced a monumental return of athlete activism when National Basketball Association (NBA) players executed a boycott of the playoffs as a result of heightened frustration after video evidence of the unjust police shooting of Jacob Blake in Kenosha, Wisconsin, surfaced on social media on August 23, 2020. NBA players (followed by WNBA players) decided to cease play and enter into discussions with league officials to garner a deal that intertwined the promotion of the Black Lives Matter movement with that of the (W)NBA playoffs; players demanded that the (W)NBA playoffs ground zero for Black Lives Matter promotion and social justice initiatives. As the “fifth wave” of athlete activists stormed the sporting world, their demand for dialogic practices is starkly different than the pioneers of the past, while also aiming to accomplish the general mission of the Heritage—racial equality through athlete activism. This article aims to analyze the new frontier of athlete activism through a Critical Race Theory lens by analyzing the ways in which the implementation of dialogic practices led to one of the most iconic waves of athlete activism in sport history.

SARS–CoV–2 and Food—How Confident Are We about Them?

The recent COVID-19 pandemic and coronaviruses have been thrust into the lives of humans around the globe. Several concerns of the scientific community, authorities and common people have been aroused concerning the prophylaxis measures that need to be taken in order to safeguard public health. Among others, the possibility of a faecal—oral route, and consequent waterborne or foodborne transmission, have been given little attention. Ground zero was the seafood market of Huanan in Wuhan, China; therefore, it was quite logical at the time to assume a certain degree of relationship between water, seafood and SARS–CoV–2. In this manuscript, a critical review of the current literature concerning these routes of transmission is made. The main questions discussed are whether (i) SARS–CoV–2 can infect food animals, (ii) it can be detected in water, retaining its infectivity for the necessary amount of time, (iii) there is a possibility of contamination of food by SARS–CoV–2 through its various production processes and (iv) there is evidence of foodborne or waterborne transmission.

Case Report: A World Trade Center (WTC) responder presenting with moderate stage dementia by age 57, suggesting an extended severity of WTC-associated illness'

Recent evidence indicates that World Trade Center Responders (WTCRs) are apparently at increased risk for a clinical syndrome that includes PTSD (posttraumatic stress disorder) and MCI (mild cognitive impairment). The association of these behavioral and cognitive symptoms was first described by Bromet, Luft, Clouston, and colleagues. No autopsy characterization of the syndrome has yet emerged, though biofluid and neuroimaging biomarker data support features of (1) progressive behavioral and cognitive dysfunction, (2) proteinopathy involving the appearance of neurodegeneration-related molecules in the peripheral circulation, and (3) a substantial regional loss of brain volume. Inciting factors such as inhalation of neurotoxins and/or psychological stressors (or a combination of both) have been proposed as contributory to the pathogenesis, but no definitive etiologic agent has been identified. In general, the subpopulation of WTCRs who developed PTSD and MCI were those with documentable extended exposure to the central feature of “Ground Zero” known as “the pile”, and those who developed MCI were primarily a subgroup of those who had developed PTSD. Multiomic studies are underway to determine whether this subgroup might be enriched for genetic, genomic, and/or proteomic features that might have predisposed them to pathological responses to stress, environmental toxins, or both. In 2017, we had occasion to evaluate “E.T.”; at that time, a 57-year-old bilingual (English and Spanish speaking) right-handed WTCR was referred to an urban medical center dementia specialty clinic for assessment of his cognitive and behavioral functioning. While early-onset dementia can occur sporadically, the proximity of E.T. to “the pile” at “Ground Zero”, and the course of E.T.’s illness raise the possibility that WTC-related cognitive-behavioral syndromes may progress well beyond the stage of MCI to that of moderate dementia (and beyond) and that this progression may occur in the absence of full-blown PTSD.