M1889 Survival After Orthotopic Liver Transplantation: the Impact of Antibody Against Hepatitis B Core Antigen in the Donor

2008 ◽  
Vol 134 (4) ◽  
pp. A-804
Author(s):  
Lei Yu ◽  
Thomas Koepsell ◽  
George Ioannou
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Orthotopic Liver Transplantation ◽  
Core Antigen ◽  
Hepatitis B Core Antigen ◽  
The Impact

Establishment of a Seronegative Occult Infection With an Active Hepatitis B Virus Reservoir Enriched of Vaccine Escape Mutations in a Vaccinated Infant After Liver Transplantation

2019 ◽  
Vol 220 (12) ◽  
pp. 1935-1939 ◽  
Author(s):  
Romina Salpini ◽  
Andrea Pietrobattista ◽  
Lorenzo Piermatteo ◽  
Maria Sole Basso ◽  
Maria C Bellocchi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Core Antigen ◽  
Occult Hepatitis ◽  
Antigen Vaccine ◽  
B Virus ◽  
Hepatitis B Core Antigen ◽  
Intrahepatic Hbv

Abstract We describe the establishment of a seronegative occult hepatitis B virus (HBV) infection (OBI) in a successfully vaccinated infant who underwent liver transplantation from an donor positive for antibody to hepatitis B core antigen (anti-HBc). The use of highly sensitive droplet digital polymerase chain reaction assays revealed a not negligible and transcriptionally active intrahepatic HBV reservoir (circular covalently closed DNA, relaxed circular DNA, and pregenomic RNA: 5.6, 2.4, and 1.1 copies/1000 cells, respectively), capable to sustain ongoing viral production and initial liver damage. Next-generation sequencing revealed a peculiar enrichment of hepatitis B surface antigen vaccine-escape mutations that could have played a crucial role in OBI transmission. This clinical case highlights the pathobiological complexity and the diagnostic challenges underlying OBI.

Risk for de novo hepatitis B from antibody to hepatitis B core antigen-Positive donors in liver transplantation in Singapore

2003 ◽  
Vol 7 (5) ◽  
pp. 469-470 ◽  
Author(s):  
Kang H. Lee ◽  
Chun T. Wai ◽  
Seng G. Lim ◽  
Kaur Manjit ◽  
Hwee L. Lee ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
De Novo ◽  
Core Antigen ◽  
De Novo Hepatitis B ◽  
Hepatitis B Core Antigen

scholarly journals The direct recovery of recombinant hepatitis B core antigen from disruptate derived from continuous-flow bead milling

2008 ◽  
Vol 50 (1) ◽  
pp. 49 ◽  
Author(s):  
Chin Woi Ho ◽  
Wen Siang Tan ◽  
Suryani Kamaruddin ◽  
Tau Chuan Ling ◽  
Beng Ti Tey
Keyword(s):  
Hepatitis B ◽  
Continuous Flow ◽  
Core Antigen ◽  
Recombinant Hepatitis ◽  
Bead Milling ◽  
Hepatitis B Core Antigen

scholarly journals Implication for Bone Marrow Derived Stem Cells in Hepatocyte Regeneration after Orthotopic Liver Transplantation

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
N. Pilat ◽  
L. Unger ◽  
G. A. Berlakovich
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Liver Transplantation ◽  
Liver Regeneration ◽  
Orthotopic Liver Transplantation ◽  
Liver Tissue ◽  
Hepatic Regeneration ◽  
Liver Growth ◽  
Cell Source ◽  
The Impact

The liver has the outstanding ability to regenerate itself and restore parenchymal tissue after injury. The most common cell source in liver growth/regeneration is replication of preexisting hepatocytes although liver progenitor cells have been postulated to participate in liver regeneration in cases of massive injury. Bone marrow derived hematopoietic stem cells (BM-HSC) have the formal capacity to act as a source for hepatic regeneration under special circumstances; however, the impact of this process in liver tissue maintenance and regeneration remains controversial. Whether BM-HSC are involved in liver regeneration or not would be of particular interest as the cells have been suggested to be an alternative donor source for the treatment of liver failure. Data from murine models of liver disease show that BM-HSC can repopulate liver tissue and restore liver function; however, data obtained from human liver transplantation show only little evidence for liver regeneration by this mechanism. The cell source for liver regeneration seems to depend on the nature of regeneration process and the extent of injury; however, the precise mechanisms still need to be resolved. Current data suggest, that in human orthotopic liver transplantation, liver regeneration by BM-HSC is a rather rare event and therefore not of clinical relevance.

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