Sa1349 Impact of Water Load Test on the Gastric Myoelectric Activity in Experimental Pigs

Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet. Pharmacokinetic parameters of donepezil and its active metabolite 6-O-desmethyldonepezil were investigated in experimental pigs with and without small intestinal injury induced by dextran sodium sulfate (DSS). Morphological features of this injury were evaluated by a video capsule endoscopy. The effect of a single and repeated doses of donepezil on gastric myoelectric activity was assessed. Both DSS-induced small intestinal injury and prolonged small intestinal transit time caused higher plasma concentrations of donepezil in experimental pigs. This has an important implication for clinical practice in humans, with a need to reduce doses of the drug if an underlying gastrointestinal disease is present. Donepezil had an undesirable impact on porcine myoelectric activity. This effect was further aggravated by DSS-induced small intestinal injury. These findings can explain donepezil-associated dyspepsia in humans.

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Preclinical electrogastrography in experimental pigs

Interdisciplinary Toxicology ◽

10.2478/v10102-010-0011-5 ◽

2010 ◽

Vol 3 (2) ◽

pp. 53-58 ◽

Cited By ~ 10

Author(s):

Jaroslav Květina ◽

Jithinraj Varayil ◽

Shahzad Ali ◽

Martin Kuneš ◽

Jan Bureš ◽

...

Keyword(s):

Dominant Frequency ◽

Intragastric Administration ◽

Myoelectric Activity ◽

Gastric Myoelectric Activity ◽

Non Invasive ◽

Pharmacology And Toxicology ◽

The Mean ◽

Set Up ◽

Important Basis ◽

Experimental Pigs

Preclinical electrogastrography in experimental pigsSurface electrogastrography (EGG) is a non-invasive means of recording gastric myoelectric activity or slow waves from cutaneous leads placed over the stomach. This paper provides a comprehensive review of preclinical EGG. Our group recently set up and worked out the methods for EGG in experimental pigs. We gained our initial experience in the use of EGG in assessment of porcine gastric myoelectric activity after volume challenge and after intragastric administration of itopride and erythromycin. The mean dominant frequency in pigs is comparable with that found in humans. EGG in experimental pigs is feasible. Experimental EGG is an important basis for further preclinical projects in pharmacology and toxicology.

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Is it time to recommend water load test before Nissen fundoplication?

Minerva Gastroenterologica e Dietologica ◽

10.23736/s1121-421x.20.02678-1 ◽

2020 ◽

Vol 66 (1) ◽

Author(s):

Amir Mari ◽

Mahmud Mahamid ◽

Tawfik Khoury

Keyword(s):

Nissen Fundoplication ◽

Load Test ◽

Water Load

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Electrogastrography in Delayed Gastric Emptying

Paediatrica Indonesiana ◽

10.14238/pi38.9-10.1998.181-92 ◽

2017 ◽

Vol 38 (9-10) ◽

pp. 181

Author(s):

Badriul Hegar ◽

Yvan Vandenplas

Keyword(s):

Gastric Emptying ◽

Gastric Motility ◽

Delayed Gastric Emptying ◽

Myoelectric Activity ◽

Gastric Emptying Rate ◽

Gastric Myoelectric Activity ◽

Enteric Nerves ◽

Gastric Muscle ◽

Abnormal Rate ◽

Smooth Muscle Contractions

Disorders of gastric motility are generally manifested by an abnormal rate of gastric emptying. The emptying process of the stomach is very complex, and knowledge is limited to the observation that gastric emptying rate is a highly variable phenomenon, and that delayed gastric emptying is frequently the case. The advances in the knowledge of the physiology of gastric muscle and enteric nerves, and the recognition of the patterns of organization of smooth muscle contractions gave a new input to the study of gastric motility. The gastric emptying can be monitored in various ways, such as manometry, scintigraphy, or electrogastrography (EGG). Recently, EGG has received more attention. There is correlation between the EGG signal obtained from body surface electrodes and signals obtained directly from electrodes locates in the gastric muscle (serosal records). Some studies showed an association between EGG-findings and gastric motility disorders, and indicate that EGG is a reliable, non-invasive, useful method to detect gastric myoelectric activity.

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