Ameliorating Effects and Mechanisms of Electroacupuncture Via Chronically Implanted Electrodes at ST36 on Gastric Slow Wave Dysrhythmia, and Delayed Emptying in a Rodent Model of Functional Dyspepsia

The aim of this study was to utilize multichannel electrogastrography to investigate whether patients with functional dyspepsia had impaired propagation or coordination of gastric slow waves in the fasting state compared with healthy controls. The study was performed in 10 patients with functional dyspepsia and 11 healthy subjects. Gastric myoelectrical activity was measured by using surface electrogastrography with a specially designed four-channel device. The study was performed for 30 min or more in the fasting state. Special computer programs were developed for the computation of the propagation and coupling of the gastric slow wave. It was found that, compared with the healthy controls, the patients showed a significantly lower percentage of slow wave propagation (58.0 ± 8.9 vs. 89.9 ± 2.6%, P < 0.002) and a significantly lower percentage of slow wave coupling (46.9 ± 4.4 vs. 61.5 ± 6.9%, P < 0.04). In addition, the patients showed inconsistencies in the frequency and regularity of the gastric slow wave among the four-channel electrogastrograms (EGGs). It was concluded that patients with functional dyspepsia have impaired slow wave propagation and coupling. Multichannel EGG has more information than single-channel EGG for the detection of gastric myoelectrical abnormalities.

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Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Neurogastroenterology & Motility ◽

10.1111/nmo.13381 ◽

2018 ◽

Vol 30 (10) ◽

Cited By ~ 6

Author(s):

S. Zhang ◽

S. Li ◽

Y. Liu ◽

F. Ye ◽

J. Yin ◽

...

Keyword(s):

Functional Dyspepsia ◽

Rodent Model ◽

Cholinergic Mechanisms ◽

Implanted Electrodes

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Effects of electroacupuncture on stress-induced gastric dysrhythmia and mechanisms involving autonomic and central nervous systems in functional dyspepsia

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00256.2019 ◽

2020 ◽

Vol 319 (1) ◽

pp. R106-R113

Author(s):

Sujuan Zhang ◽

Yi Liu ◽

Shiying Li ◽

Feng Ye ◽

Robert D. Foreman ◽

...

Keyword(s):

Functional Dyspepsia ◽

Restraint Stress ◽

Rodent Model ◽

Plasma Norepinephrine ◽

Vagal Activity ◽

Plastic Tube ◽

Gastric Dysrhythmia ◽

Gastric Slow Wave ◽

Cell Counts ◽

Acute Restraint Stress

Electroacupuncture (EA) is widely used as an effective method to treat stress-related disorders. However, its mechanisms remain largely unknown. The aim of this study was to investigate the effects and mechanisms of EA on gastric slow wave (GSW) dysrhythmia and c-Fos expression in the nucleus of the solitary tract (NTS) induced by stress in a rodent model of functional dyspepsia (FD). Rats in the neonatal stage were treated using intragastric iodoacetamide. Eight weeks later, the rats were implanted with electrodes in the stomach for the measurement of GSW and electrodes into accupoints ST36 for EA. Autonomic functions were assessed by spectral analysis of heart rate variability. Rats were placed for 30 min in a cylindrical plastic tube for acute restraint stress. The involvement of a central afferent pathway was assessed by measuring c-Fos-immunoreactive cells in the NTS. 1) EA normalized restraint stress-induced impairment of GSW in FD rats. 2) EA significantly increased vagal activity ( P = 0.002) and improved sympathovagal balance ( P = 0.004) under stress in FD rats. 3) In FD rats under restraint stress, plasma norepinephrine concentration was increased substantially ( P < 0.01), which was suppressed with EA. 4) The EA group showed increased c-Fos-positive cell counts in the NTS compared with the sham EA group ( P < 0.05) in FD rats. Acute restraint stress induces gastric dysrhythmia in a rodent model of FD. EA at ST36 improves GSW under stress in FD rats mediated via the central and autonomic pathways, involving the NTS and vagal efferent pathway.

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Clinical Associations of Functional Dyspepsia with Gastric Dysrhythmia on Electrogastrography: A Comprehensive Systematic Review and Meta-Analysis

10.1101/2021.01.19.21250140 ◽

2021 ◽

Cited By ~ 1

Author(s):

C Varghese ◽

DA Carson ◽

S Bhat ◽

TCL Hayes ◽

AA Gharibans ◽

...

Keyword(s):

Functional Dyspepsia ◽

Slow Wave ◽

Meta Analysis ◽

Dominant Frequency ◽

Gastric Electrical Activity ◽

Gastric Dysrhythmia ◽

Gastric Slow Wave ◽

Clinical Associations ◽

Secondary Outcomes ◽

Underlying Mechanisms

AbstractBackgroundFunctional dyspepsia (FD) is a common gastroduodenal disorder, yet its pathophysiology remains poorly understood. Bioelectrical gastric slow wave abnormalities are thought to contribute to its multifactorial pathophysiology. Electrogastrography (EGG) has been used to record gastric electrical activity, however the clinical associations require further evaluation.AimsThis study aimed to systematically assess the clinical associations of EGG in FD.MethodsMEDLINE, EMBASE, and CENTRAL databases were systematically searched for articles using EGG in adults with FD. Primary outcomes were percentage normal vs abnormal rhythm (bradygastria, normogastria, tachygastria). Secondary outcomes were dominant power, dominant frequency, percentage coupling and the meal responses.Results1751 FD patients and 555 controls from 47 studies were included. FD patients spent less time in normogastria while fasted (SMD −0.74; 95%CI −1.22 - −0.25) and postprandially (−0.86; 95%CI −1.35 - −0.37) compared to controls. FD patients also spent more fasted time in bradygastria (0.63; 95%CI 0.33 – 0.93) and tachygastria (0.45; 95%CI 0.12 – 0.78%). The power ratio (−0.17; 95%CI −0.83 - 0.48), and dominant frequency meal-response ratio (0.06; 95%CI −0.08 - 0.21) were not significantly different to controls. Correlations between EGG metrics and the presence and timing of FD symptoms were inconsistent. EGG methodologies were diverse and variably applied.ConclusionAbnormal gastric slow wave rhythms are a consistent abnormality present in FD, as defined by EGG, and therefore likely play a role in pathophysiology. The aberrant electrophysiology identified in FD warrants further investigation, including into underlying mechanisms, associated spatial patterns, and symptom correlations.

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Serosal and cutaneous recordings of gastric myoelectrical activity in patients with gastroparesis

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1994.266.1.g90 ◽

1994 ◽

Vol 266 (1) ◽

pp. G90-G98 ◽

Cited By ~ 14

Author(s):

J. D. Chen ◽

B. D. Schirmer ◽

R. W. McCallum

Keyword(s):

Electrical Stimulation ◽

Slow Wave ◽

Test Meal ◽

Frequency Change ◽

Fasting State ◽

Gastric Myoelectrical Activity ◽

Myoelectrical Activity ◽

Gastric Slow Wave ◽

Student’S T ◽

Student’S T Test

The aims of this study were to 1) investigate gastric myoelectrical activity in patients with gastroparesis, 2) validate the cutaneous electrogastrogram (EGG) in tracking the frequency change of the gastric slow wave, and 3) investigate the effect of electrical stimulation on gastric myoelectrical activity. Gastric myoelectrical activity was recorded in 12 patients with documented gastroparesis using serosal electrodes for > 200 min in each subject. All recordings were made at least 4 days after surgery. Each session consisted of a 30-min recording in the fasting state and a 30-min recording after a test meal. The test meal (liquid or mixed) was selected according to patient's tolerance. Electrical stimulation was performed in three subjects via the serosal electrodes at a frequency of 3 cycles/min. Gastric myoelectrical activity was recorded using serosal electrodes in each session. The serosal recording showed slow waves of 2.5 to 4.0 cycles/min in all 12 subjects. Absence of spikes was noted in 11 of the 12 subjects. The simultaneous serosal and cutaneous recording of gastric myoelectrical activity showed that the frequency of the EGG was exactly the same as that of the serosal recording. Liquid meals resulted in a significant decrease in slow-wave frequency (Student's t test, P = 0.006), and the EGG accurately reflected this change. Electrical stimulation had no effect on the frequency of the gastric slow wave and did not induce spikes.(ABSTRACT TRUNCATED AT 250 WORDS)

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