scholarly journals Effects of electroacupuncture on stress-induced gastric dysrhythmia and mechanisms involving autonomic and central nervous systems in functional dyspepsia

2020 ◽  
Vol 319 (1) ◽  
pp. R106-R113
Author(s):  
Sujuan Zhang ◽  
Yi Liu ◽  
Shiying Li ◽  
Feng Ye ◽  
Robert D. Foreman ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Restraint Stress ◽  
Rodent Model ◽  
Plasma Norepinephrine ◽  
Vagal Activity ◽  
Plastic Tube ◽  
Gastric Dysrhythmia ◽  
Gastric Slow Wave ◽  
Cell Counts ◽  
Acute Restraint Stress

Electroacupuncture (EA) is widely used as an effective method to treat stress-related disorders. However, its mechanisms remain largely unknown. The aim of this study was to investigate the effects and mechanisms of EA on gastric slow wave (GSW) dysrhythmia and c-Fos expression in the nucleus of the solitary tract (NTS) induced by stress in a rodent model of functional dyspepsia (FD). Rats in the neonatal stage were treated using intragastric iodoacetamide. Eight weeks later, the rats were implanted with electrodes in the stomach for the measurement of GSW and electrodes into accupoints ST36 for EA. Autonomic functions were assessed by spectral analysis of heart rate variability. Rats were placed for 30 min in a cylindrical plastic tube for acute restraint stress. The involvement of a central afferent pathway was assessed by measuring c-Fos-immunoreactive cells in the NTS. 1) EA normalized restraint stress-induced impairment of GSW in FD rats. 2) EA significantly increased vagal activity ( P = 0.002) and improved sympathovagal balance ( P = 0.004) under stress in FD rats. 3) In FD rats under restraint stress, plasma norepinephrine concentration was increased substantially ( P < 0.01), which was suppressed with EA. 4) The EA group showed increased c-Fos-positive cell counts in the NTS compared with the sham EA group ( P < 0.05) in FD rats. Acute restraint stress induces gastric dysrhythmia in a rodent model of FD. EA at ST36 improves GSW under stress in FD rats mediated via the central and autonomic pathways, involving the NTS and vagal efferent pathway.

Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats

2010 ◽  
Vol 298 (4) ◽  
pp. G563-G570 ◽  
Author(s):  
Jieyun Yin ◽  
Jie Chen ◽  
Jiande D. Z. Chen
Keyword(s):  
Therapeutic Potential ◽  
Diabetic Rats ◽  
Intestinal Transit ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Small Intestinal Transit ◽  
Gastric Dysrhythmia ◽  
Gastric Slow Wave ◽  
Normal Percentage ◽  
Small Intestinal

The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats. The normal percentage of slow waves was 55.4 ± 2.9% at baseline and significantly increased to 69.2 ± 2.2% with EA ( P = 0.01); this effect was blocked by naloxone. 2) EA resulted in a 21.4% increase in GE and 18.2% increase in small intestinal transit in the diabetic rats. 3) EA restored diabetes-induced impairment in gastric accommodation. Gastric accommodation was 0.98 ± 0.13 ml with sham EA and significantly increased to 1.21 ± 0.15 ml with EA ( P = 0.01), and this effect was blocked by naloxone. 4) EA increased vagal activity assessed by the spectral analysis of the heart rate variability. We concluded that EA at ST-36 improves gastric dysrhythmia, delayed GE and intestinal transit, and impaired accommodation in STZ-induced diabetic rats, and the improvement seems to be mainly mediated via the vagal pathway. EA may have a promising therapeutic potential for diabetic gastroparesis.

T1332 Electroacupuncture Improves Impaired Gastric Accommodation and Vagal Activity in a Novel Rodent Model of Functional Dyspepsia

2008 ◽  
Vol 134 (4) ◽  
pp. A-533 ◽  
Author(s):  
Geng-Qing Song ◽  
Yan Sun ◽  
Liansheng Liu ◽  
Pankaj J. Pasricha ◽  
Jiande Chen
Keyword(s):  
Functional Dyspepsia ◽  
Rodent Model ◽  
Vagal Activity ◽  
Gastric Accommodation

scholarly journals Clinical Associations of Functional Dyspepsia with Gastric Dysrhythmia on Electrogastrography: A Comprehensive Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
C Varghese ◽  
DA Carson ◽  
S Bhat ◽  
TCL Hayes ◽  
AA Gharibans ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Slow Wave ◽  
Meta Analysis ◽  
Dominant Frequency ◽  
Gastric Electrical Activity ◽  
Gastric Dysrhythmia ◽  
Gastric Slow Wave ◽  
Clinical Associations ◽  
Secondary Outcomes ◽  
Underlying Mechanisms

AbstractBackgroundFunctional dyspepsia (FD) is a common gastroduodenal disorder, yet its pathophysiology remains poorly understood. Bioelectrical gastric slow wave abnormalities are thought to contribute to its multifactorial pathophysiology. Electrogastrography (EGG) has been used to record gastric electrical activity, however the clinical associations require further evaluation.AimsThis study aimed to systematically assess the clinical associations of EGG in FD.MethodsMEDLINE, EMBASE, and CENTRAL databases were systematically searched for articles using EGG in adults with FD. Primary outcomes were percentage normal vs abnormal rhythm (bradygastria, normogastria, tachygastria). Secondary outcomes were dominant power, dominant frequency, percentage coupling and the meal responses.Results1751 FD patients and 555 controls from 47 studies were included. FD patients spent less time in normogastria while fasted (SMD −0.74; 95%CI −1.22 - −0.25) and postprandially (−0.86; 95%CI −1.35 - −0.37) compared to controls. FD patients also spent more fasted time in bradygastria (0.63; 95%CI 0.33 – 0.93) and tachygastria (0.45; 95%CI 0.12 – 0.78%). The power ratio (−0.17; 95%CI −0.83 - 0.48), and dominant frequency meal-response ratio (0.06; 95%CI −0.08 - 0.21) were not significantly different to controls. Correlations between EGG metrics and the presence and timing of FD symptoms were inconsistent. EGG methodologies were diverse and variably applied.ConclusionAbnormal gastric slow wave rhythms are a consistent abnormality present in FD, as defined by EGG, and therefore likely play a role in pathophysiology. The aberrant electrophysiology identified in FD warrants further investigation, including into underlying mechanisms, associated spatial patterns, and symptom correlations.

Acute restraint stress has a similar effect on visceral sensitivity in different types of maternal deprivation in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A715-A715
Author(s):  
A ROSZTOCZY ◽  
S BRADESI ◽  
C BEAUFRAND ◽  
J FIORAMONTI ◽  
T WITTMANN ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Maternal Deprivation ◽  
Visceral Sensitivity ◽  
Acute Restraint Stress ◽  
Different Types

scholarly journals Acute Restraint Stress Alters Wheel-Running Behavior Immediately Following Stress and up to 20 Hours Later in House Mice

2016 ◽  
Vol 89 (6) ◽  
pp. 546-552 ◽  
Author(s):  
Jessica L. Malisch ◽  
Karen deWolski ◽  
Thomas H. Meek ◽  
Wendy Acosta ◽  
Kevin M. Middleton ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Wheel Running ◽  
House Mice ◽  
Acute Restraint Stress

scholarly journals Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying

2017 ◽  
Vol 46 (2) ◽  
pp. 792-801 ◽  
Author(s):  
W-J Guo ◽  
S-K Yao ◽  
Y-L Zhang ◽  
S-Y Du ◽  
H-F Wang ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Delayed Gastric Emptying ◽  
Low Frequency ◽  
Treatment Method ◽  
Frequency Component ◽  
High Frequency Component ◽  
Vagal Activity ◽  
Nervous Function

Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio. Results Overall and proximal GE were delayed in 47.2% and 50.9% of the patients, respectively. Spectral analysis of HRV showed that the HF in patients with delayed proximal GE was significantly lower and that the LF/HF ratio was significantly higher than those in patients with normal proximal GE after a meal. Conclusion Delayed proximal GE might be caused by disrupted sympathovagal balance as a result of decreased vagal activity after a meal. Improvement in vagal activity may constitute an effective treatment method for patients with FD.

Neuropeptidase activities in plasma after acute restraint stress. Interaction with cortico-limbic areas

2016 ◽  
Vol 28 (4) ◽  
pp. 239-243 ◽  
Author(s):  
Ana Belén Segarra ◽  
Joaquín Hernández ◽  
Isabel Prieto ◽  
Marc de Gasparo ◽  
Manuel Ramírez-Sánchez
Keyword(s):  
Restraint Stress ◽  
Enzymatic Activities ◽  
Stress Conditions ◽  
Acute Restraint Stress ◽  
Limbic Regions

ObjectiveTo evaluate the influence of acute restraint stress (ARS) on plasma enkephalinase and oxytocinase activities. ARS modifies basal activities in cortico-limbic regions of rats and induces changes in the correlations observed between these regions. The interactions between plasma and cortico-limbic activities will be also evaluated.MethodsEnkephalinase (AlaAP and LeuAP) and oxytocinase (P-LeuAP) activities were fluorometrically determined in plasma of control and stressed rats using aminoacyl-β-naphthylamides (aaNNap), AlaNNap and LeuNNap as substrates.ResultsNo differences in enzymatic activities were observed between control and stressed animals in plasma. In contrast, highly significant positive and negative correlations between plasma and cortico-limbic regions were demonstrated in controls. Stress conditions significantly alter the pattern of these correlations.ConclusionThe present results clearly support a connection between plasma and brain involving certain neuropeptidase activities that change under stress conditions.

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