Background. The present study aimed to evaluate the efficacy of linked color imaging (LCI) in diagnosing Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). Methods. A total of 112 and 12 consecutive patients with BE and EAC were analyzed. The visibility scores of BE and EAC ranging from 4 (excellent visibility) to 0 (not detectable) were evaluated by three trainees and three experts using white light imaging (WLI), LCI mode, and blue laser imaging bright (BLI-b) mode. In addition,
L
∗
a
∗
b
∗
color values and color differences (
Δ
E
∗
) were evaluated using the CIELAB color space system. Results. The visibility score of the BE in LCI mode (
2.94
±
1.32
) was significantly higher than those in WLI (
2.46
±
1.48
) and BLI-b mode (
2.35
±
1.46
) (
p
<
0.01
). The color difference (
Δ
E
∗
) from the adjacent gastric mucosa in LCI mode (
17.11
±
8.53
) was significantly higher than those in other modes (
12.52
±
9.37
in WLI and
11.96
±
6.59
in BLI-b mode,
p
<
0.01
). The visibility scores of EAC in LCI mode (
2.56
±
1.47
) and BLI-b mode (
2.51
±
1.28
) were significantly higher than that in WLI (
1.64
±
1.46
) (
p
<
0.01
). The color difference (
Δ
E
∗
) from the adjacent normal Barrett’s mucosa in LCI mode (
19.96
±
7.97
) was significantly higher than that in WLI (
12.95
±
11.86
) (
p
=
0.03
). Conclusion. The present findings suggest that LCI increases the visibility of BE and EAC and contributes to the improvement of the detection of these lesions.
Sa1158 – Linked Color Imaging (LCI), a Novel Image-Enhanced Endoscopy, is Useful for Improving Visibility of Superficial Barrett's Esophageal Adenocarcinoma
