1.P.357 Hemodynamic forces are associated with common carotid wall thickness in healthy subjects

Background:Carotid contrast enhanced ultrasound (CEUS) is used for diagnosis and activity determination of patients with Takayasu’s arteritis (TA). However, very little is known about the carotid CEUS features of TA complicated with Behcet’s disease (BD).Objectives:This study reports the carotid CEUS features in cases of TA complicated with BD (TBD).Methods:A total of 10 carotid CEUS examinations were performed on 4 patients of TBD. 10 TA patients complicated with no rheumatoid disease were included as control group. For each carotid artery lesion, the carotid CEUS features was graded as follows: Grade 0, artery wall shows no microbubbles, Grade 1, artery wall shows limited or moderate microbubbles, Grade 2, artery wall shows severe microbubbles.Results:2/10 patients in TBD group has oral ulcer during the CEUS examination, while all the other patients included in our study showed no clinical symptoms related to active TA or BD. The carotid wall thickness was greater of CEUS grade 2 than grade 1 in both group(TBD: 2.62±0.74mm vs 1.66±0.22mm,p=0.001; TA:1.84±0.31mm vs 1.53±0.5mm,p=0.136). The carotid wall thickness was significantly greater in TBD group than TA group, but there was no significant differences between the two groups in clinical data and CEUS grade (table 1).Table 1.Clinical data and carotid CEUS features of both groupsTBDTApAge (year)32.5±3.4430.5±9.20.487Male320.605ESR (mm/h)4(2, 10)7(3.5, 11)0.406CRP (mg/L)6.42(0.55, 15.38)0.58(0.44, 5.05)0.168Wall thickness (mm)2.10±0.701.67±0.440.030CEUS grade 29120.527Conclusion:This study first shows carotid CEUS features in cases of TA complicated with BD, which may help with the comprehensive treatments of the disease.Disclosure of Interests: :None declared

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Ethnic Differences in Carotid Wall Thickness

Stroke ◽

10.1161/01.str.27.10.1744 ◽

1996 ◽

Vol 27 (10) ◽

pp. 1744-1749 ◽

Cited By ~ 69

Author(s):

Ralph B. D'Agostino ◽

Gregory Burke ◽

Dan O'Leary ◽

Marian Rewers ◽

Joseph Selby ◽

...

Keyword(s):

Ethnic Differences ◽

Wall Thickness ◽

Carotid Wall

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P737 Left ventricular hemodynamic forces: towards establishing reference values for healthy adults

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.406 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

F Capuano ◽

R Cocchia ◽

F Ferrara ◽

S Lanero ◽

V Russo ◽

...

Keyword(s):

Reference Values ◽

Healthy Subjects ◽

Left Ventricular ◽

Healthy Adults ◽

Disease Assessment ◽

Lv Function ◽

Specific Reference ◽

Endocardial Contour ◽

Hemodynamic Forces ◽

Lv Volume

Abstract Introduction Left ventricular hemodynamic forces (LV-HDF) have been recently demonstrated to be promising markers of sub-clinical dysfunction and potential predictors of disease outcome. However, there is a lack of reference values in healthy subjects. Knowledge of physiologic ranges is mandatory towards the use of LV-HDF-based indices for disease assessment in future clinical applications. Purpose Aim of the current study is to define the normal reference values for LV-HDF parameters in a large cohort of healthy adults. Here we present preliminary results for the initial set of enrolled subjects. Methods We enrolled 82 healthy subjects [mean age 44 ± 13.2 years (range 18-88), 41 men]. All participants underwent standard transthoracic echocardiography (TTE) examination, as recommended by current guidelines, including apical two-, three- and four-chamber windows, acquired at a frame rate above 40 Hz. These were then analyzed by tri-plane tissue tracking, measuring LV volume and LV ejection fraction (EF) as reference parameters. The same tracking method was used to evaluate the global hemodynamic force by a novel mathematical calculation technique applied to the three-dimensional endocardial contour. Physical-based LV-HDF parameters were then extracted for clinical application; these included the amplitude (root mean square) of the longitudinal and transversal force components (FL and FT) and their alignment angle relative to the LV axis. Parameters were computed as average over the whole cardiac cycle as well as limited to the systolic phase. Forces were normalized with LV volume to reduce variability with LV dimension, and divided by specific weight to yield a dimensionless measure. Results Mean EF was 63 ± 9%. Whole cycle LV-HDF parameters were: FL = 16.0 ± 5.6%, FT = 2.3 ± 0.8%, with significant longitudinal alignment FT/FL = 0.15 ± 0.04, angle = 13.0°±3.1°. Systolic HDF parameters were: FL = 22.7 ± 8.2%, FT = 2.9 ± 1.1%, with longitudinal alignment FT/FL = 0.13 ± 0.04, angle = 11.2°±3.1°. Importantly, dimensionless physical-based LV-HDF parameters showed no significant variation with age, gender or BSA. Conclusions We report the physiologic range of LV-HDF parameters measured by TTE. Knowledge of age- and gender-specific reference values, for a combination of standard, mechanical and hemodynamic indices, can improve the global assessment of the LV function and may help to detect sub-clinical stages of LV dysfunction.

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Association of Long-Term Risk Factor Levels With Carotid Atherosclerosis

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.119.009226 ◽

2019 ◽

Vol 12 (9) ◽

Author(s):

Jarett D. Berry ◽

Anurag Mehta ◽

Kai Lin ◽

Colby R. Ayers ◽

Timothy Carroll ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Total Cholesterol ◽

Young Adulthood ◽

Wall Thickness ◽

Carotid Atherosclerosis ◽

Necrotic Core ◽

Low Risk ◽

Carotid Wall

Background: Absence of cardiovascular risk factors (RF) in young adulthood is associated with a lower risk for cardiovascular disease. However, it is unclear if low RF burden in young adulthood decreases the quantitative burden and qualitative features of atherosclerosis. Methods: Multi-contrast carotid magnetic resonance imaging was performed on 440 Chicago Healthy Aging Study participants in 2009 to 2011, whose RF (total cholesterol, blood pressure, diabetes mellitus, and smoking) were measured in 1967 to 1973. Participants were divided into 4 groups: low-risk (with total cholesterol <200 mg/dL and no treatment, blood pressure <120/80 mm Hg and no treatment, no smoking, and no diabetes mellitus), 0 high RF but some RF unfavorable (≥1 RF above low-risk threshold but below high-risk threshold), 1 high RF (total cholesterol ≥240 mg/dL or treated, blood pressure ≥140/90 or treated, diabetes mellitus, or smoking), and 2 or more high RF. Association of baseline RF status with carotid atherosclerosis (overall mean carotid wall thickness and lipid-rich necrotic core) at follow-up was assessed. Results: Among 424 participants with evaluable carotid magnetic resonance images, the mean age was 32 years at baseline and 73 years at follow-up; 67% were male, 86% white, and 36% were low-risk at baseline. Two or more high RF status was associated with higher carotid wall thickness (0.99±0.11 mm) and lipid-rich necrotic core prevalence (30%), as compared with low-risk group (0.94±0.09 mm and 17%, respectively). Each increment in baseline RF status was associated with higher carotid wall thickness (β-coefficient, 0.015; 95% CI, 0.004–0.026) and with higher lipid-rich necrotic core prevalence at older age (odds ratio, 1.26; 95% CI, 1.00–1.58) in models adjusted for baseline RF and demographics. Conclusions: RF status in young adulthood is associated with the burden and quality of carotid atherosclerosis in older age suggesting that the decades-long protective effect of low-risk status might be mediated through a lower burden of quantitative and qualitative features of atherosclerotic plaque.

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MTHFR mutation and carotid wall thickness in aging non diabetic women

Atherosclerosis ◽

10.1016/s0021-9150(99)80385-2 ◽

1999 ◽

Vol 144 ◽

pp. 100

Author(s):

A. Passaro ◽

A. Vannini ◽

K. D'Elia ◽

F. Calzoni ◽

M. Carantoni ◽

...

Keyword(s):

Wall Thickness ◽

Mthfr Mutation ◽

Carotid Wall

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Modulation of Circulating Cytokine-Chemokine Profile in Patients Affected by Chronic Venous Insufficiency Undergoing Surgical Hemodynamic Correction

Journal of Immunology Research ◽

10.1155/2014/473765 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 17

Author(s):

Veronica Tisato ◽

Giorgio Zauli ◽

Sergio Gianesini ◽

Erica Menegatti ◽

Laura Brunelli ◽

...

Keyword(s):

Varicose Vein ◽

Chronic Venous Insufficiency ◽

Healthy Subjects ◽

General Circulation ◽

Venous Insufficiency ◽

Ex Vivo ◽

Hemodynamic Forces ◽

Circulating Levels

The expression of proinflammatory cytokines/chemokines has been reported inin vitro/ex vivosettings of chronic venous insufficiency (CVI), but the identification of circulating mediators that might be associated with altered hemodynamic forces or might represent innovative biomarkers is still missing. In this study, the circulating levels of 31 cytokines/chemokines involved in inflammatory/angiogenic processes were analysed in (i) CVI patients at baseline before surgical hemody namic correction, (ii) healthy subjects, and (iii) CVI patients after surgery. In a subgroup of CVI patients, in whom the baseline levels of cytokines/chemokines were analyzed in paired blood samples obtained from varicose vein and forearm vein, EGF, PDGF, and RANTES were increased at the varicose vein site as compared to the general circulation. Moreover, while at baseline, CVI patients showed increased levels of 14 cytokines/chemokines as compared to healthy subjects, 6 months after surgery, 11 cytokines/chemokines levels were significantly reduced in the treated CVI patients as compared to the CVI patients before surgery. Of note, a patient who exhibited recurrence of the disease 6 months after surgery, showed higher levels of EGF, PDGF, and RANTES compared to nonrecurrent patients, highlighting the potential role of the EGF/PDGF/RANTES triad as sensitive biomarkers in the context of CVI.

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