AB0474 CAROTID CONTRAST ENHANCED ULTRASOUND IN CASES OF TAKAYASU ARTERITIS COMPLICATED WITH BEHCET’S DISEASE

Background:Carotid contrast enhanced ultrasound (CEUS) is used for diagnosis and activity determination of patients with Takayasu’s arteritis (TA). However, very little is known about the carotid CEUS features of TA complicated with Behcet’s disease (BD).Objectives:This study reports the carotid CEUS features in cases of TA complicated with BD (TBD).Methods:A total of 10 carotid CEUS examinations were performed on 4 patients of TBD. 10 TA patients complicated with no rheumatoid disease were included as control group. For each carotid artery lesion, the carotid CEUS features was graded as follows: Grade 0, artery wall shows no microbubbles, Grade 1, artery wall shows limited or moderate microbubbles, Grade 2, artery wall shows severe microbubbles.Results:2/10 patients in TBD group has oral ulcer during the CEUS examination, while all the other patients included in our study showed no clinical symptoms related to active TA or BD. The carotid wall thickness was greater of CEUS grade 2 than grade 1 in both group(TBD: 2.62±0.74mm vs 1.66±0.22mm,p=0.001; TA:1.84±0.31mm vs 1.53±0.5mm,p=0.136). The carotid wall thickness was significantly greater in TBD group than TA group, but there was no significant differences between the two groups in clinical data and CEUS grade (table 1).Table 1.Clinical data and carotid CEUS features of both groupsTBDTApAge (year)32.5±3.4430.5±9.20.487Male320.605ESR (mm/h)4(2, 10)7(3.5, 11)0.406CRP (mg/L)6.42(0.55, 15.38)0.58(0.44, 5.05)0.168Wall thickness (mm)2.10±0.701.67±0.440.030CEUS grade 29120.527Conclusion:This study first shows carotid CEUS features in cases of TA complicated with BD, which may help with the comprehensive treatments of the disease.Disclosure of Interests: :None declared

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SAT0609 Venous vessel wall thickness in lower extremity is increased in male behcet’s disease patients with and without vascular involvement

10.1136/annrheumdis-2018-eular.2858 ◽

2018 ◽

Author(s):

F. Alibaz-Oner ◽

R. Ergelen ◽

A. Mutis ◽

Z. Erturk ◽

R. Asadov ◽

...

Keyword(s):

Lower Extremity ◽

Behçet’S Disease ◽

Wall Thickness ◽

Vessel Wall ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Vascular Involvement ◽

Behcet's Disease ◽

Vessel Wall Thickness ◽

Venous Vessel

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Venous vessel wall thickness in lower extremity is increased in male patients with Behcet’s disease

Clinical Rheumatology ◽

10.1007/s10067-019-04470-z ◽

2019 ◽

Vol 38 (5) ◽

pp. 1447-1451 ◽

Cited By ~ 7

Author(s):

Fatma Alibaz-Oner ◽

Rabia Ergelen ◽

Aydan Mutis ◽

Zeynep Erturk ◽

Ruslan Asadov ◽

...

Keyword(s):

Lower Extremity ◽

Behçet’S Disease ◽

Wall Thickness ◽

Vessel Wall ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Behcet's Disease ◽

Vessel Wall Thickness ◽

Male Patients ◽

Venous Vessel

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Assessment of venous wall thickness with Doppler ultrasonography may be a diagnostic tool for Behçet’s disease

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.13574 ◽

2019 ◽

Vol 22 (5) ◽

pp. 767-768

Author(s):

Fatma Alibaz‐Oner ◽

Haner Direskeneli

Keyword(s):

Behçet’S Disease ◽

Wall Thickness ◽

Diagnostic Tool ◽

Doppler Ultrasonography ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Behcet's Disease ◽

Venous Wall

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THU0557 Venous vessel wall thickness in lower extremity is increased in male behcet's disease patients without vascular involvement

10.1136/annrheumdis-2017-eular.4125 ◽

2017 ◽

Cited By ~ 2

Author(s):

F Alibaz-Oner ◽

A Mutis ◽

R Ergelen ◽

Z Erturk ◽

T Ergun ◽

...

Keyword(s):

Lower Extremity ◽

Behçet’S Disease ◽

Wall Thickness ◽

Vessel Wall ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Vascular Involvement ◽

Behcet's Disease ◽

Vessel Wall Thickness ◽

Venous Vessel

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Femoral vein wall thickness measurement: A new diagnostic tool for Behçet’s disease

Rheumatology ◽

10.1093/rheumatology/keaa264 ◽

2020 ◽

Vol 60 (1) ◽

pp. 288-296 ◽

Cited By ~ 1

Author(s):

Fatma Alibaz-Oner ◽

Rabia Ergelen ◽

Yasin Yıldız ◽

Mustafa Aldag ◽

Ayten Yazici ◽

...

Keyword(s):

Behçet’S Disease ◽

Wall Thickness ◽

Diagnostic Tool ◽

Predictive Value ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Femoral Vein ◽

Thickness Measurement ◽

Control Groups ◽

Behcet's Disease

Abstract Objectives Diagnosing Behçet’s disease (BD) is a challenge, especially in countries with a low prevalence. Recently, venous wall thickness (VWT) in lower extremities has been shown to be increased in BD patients. In this study, we aimed to investigate the diagnostic performance of common femoral vein (CFV) thickness measurement in BD and whether it can be used as a diagnostic tool. Methods . Patients with BD (n = 152), ankylosing spondylitis (n = 27), systemic vasculitides (n = 23), venous insufficiency (n = 29), antiphospholipid syndrome (APS; n = 43), deep vein thrombosis due to non-inflammatory causes (n = 25) and healthy controls (n = 51) were included in the study. Bilateral CFV thickness was measured with ultrasonography by a radiologist blinded to cases. Results Bilateral CFV thickness was significantly increased in BD compared with all control groups (P < 0.001 for all). The area under the receiver operating characteristic curve for bilateral CFV thicknesses in all comparator groups was >0.95 for the cut-off value (0.5 mm). This cut-off value also performed well against all control groups with sensitivity rates >90%. The specificity rate was also >80% in all comparator groups except APS (positive predictive value: 79.2–76.5%, negative predictive value: 92–91.8% for right and left CFV, respectively). Conclusion Increased CFV thickness is a distinctive feature of BD and is rarely present in healthy and diseased controls, except APS. Our results suggest that CFV thickness measurement with ultrasonography, a non-invasive radiological modality, can be a diagnostic tool for BD with sensitivity and the specificity rates higher than 80% for the cut-off value ≥0.5 mm.

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HLA antigens associated with Behcet's disease

Archives of Dermatology ◽

10.1001/archderm.113.12.1720 ◽

1977 ◽

Vol 113 (12) ◽

pp. 1720-1721 ◽

Cited By ~ 4

Author(s):

F. Ersoy

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Hla Antigens ◽

Behcet's Disease

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Coagulation and Fibrinolytic Activity in Behçet's Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646409 ◽

1991 ◽

Vol 66 (03) ◽

pp. 292-294 ◽

Cited By ~ 57

Author(s):

K K Hampton ◽

M A Chamberlain ◽

D K Menon ◽

J A Davies

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Behçet’S Disease ◽

Fibrinolytic Activity ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Plasminogen Activator Inhibitor ◽

Behcet's Disease ◽

Tissue Plasminogen ◽

Von Willebrand

SummaryCoagulation and fibrinolytic activities were studied in 18 subjects with Behçet's disease and compared with results from 14 matched control patients suffering from sero-negative arthritis. Significantly higher plasma concentrations (median and range) were found in Behçet's patients for the following variables: fibrinogen 3.7 (1.7-6.9) vs 3.0 (2.0-5.1) g/1, p <0.05; von Willebrand factor antigen, 115 (72-344) vs 74 (60-119)%, p <0.002; plasminogen activator activity (106/ECLT2) 219 (94-329) vs 137 (78-197) units, p <0.002; tissue plasminogen activator inhibitor (t-PA-I) activity, 9.1 (5.5-19.3) vs 5.1 (1.8-12.0) IU/ml, p <0.002; and PAI-1 antigen, 13.9 (4.5-20.9) vs 6.4 (2.4-11.1) ng/ml, p <0.002. Protein C antigen was significantly lower: 97 (70-183) vs 126 (96-220)%, p <0.02. No differences were observed in antithrombin III activity or antigen, factor VIII coagulant activity, fibrinopeptides A and Bβ15-42, plasminogen, α-2-antiplasmin, functional and immunological tissue-plasminogen activator, thrombin-antithrombin complexes and D-dimer. Levels of tissue plasminogen activator inhibitor (activity and antigen) correlated with disease activity while fibrinogen and von Willebrand factor concentrations did not. Seven of the 18 subjects with Behçet's disease had suffered thrombotic events but it was not possible to distinguish these from the 11 patients without thrombosis using the assays performed. The results suggest the abnormal fibrinolytic activity in Behçet's disease is due to increased inhibition of tissue plasminogen activator. No abnormality of coagulation or fibrinolytic activity specific to Behçet's disease was detected.

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