scholarly journals The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.

1994 ◽  
Vol 269 (9) ◽  
pp. 6949-6954
Author(s):  
L.C. Quattrochi ◽  
T. Vu ◽  
R.H. Tukey
Keyword(s):  
Receptor Binding ◽  
Ah Receptor ◽  
Specific Induction ◽  
Human Cyp1a2

scholarly journals A QSAR evaluation of Ah receptor binding of halogenated aromatic xenobiotics.

1996 ◽  
Vol 104 (12) ◽  
pp. 1302-1310 ◽  
Author(s):  
O G Mekenyan ◽  
G D Veith ◽  
D J Call ◽  
G T Ankley
Keyword(s):  
Receptor Binding ◽  
Ah Receptor

Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation

1993 ◽  
Vol 45 (5) ◽  
pp. 1129-1136 ◽  
Author(s):  
Peter H. Jellinck ◽  
P. Gekforkert ◽  
David S. Riddick ◽  
Allan B. Okey ◽  
Jon J. Michnovicz ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Ah Receptor ◽  
Binding Properties

scholarly journals Phenobarbital-induced expression of cytochrome P450 genes.

2000 ◽  
Vol 47 (4) ◽  
pp. 1093-1105 ◽  
Author(s):  
P Czekaj
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Cytochromes P450 ◽  
Ah Receptor ◽  
Binding Motif ◽  
Orphan Receptors ◽  
Nuclear Factors ◽  
Cyp1a1 Gene ◽  
Polycyclic Aromatic ◽  
Nuclear Factor 1

In contrast to the well-known Ah receptor-mediated regulation of the CYP1A1 gene by polycyclic aromatic hydrocarbons, the molecular mechanism by which phenobarbital (PB) and PB-like inducers affect transcription of CYP genes remains unknown; no receptor for these chemicals has been found to date. However, in the last 5 years PB-responsive sequences have been identified in the 5' flanking regions of several P450 genes. The phenobarbital-responsive enhancer unit (PBRU) of CYP2B gene family members contain two potential nuclear receptor binding sites (NR1 and NR2) that flank a nuclear factor 1 (NF-1) binding motif. The nuclear factors that regulate PBRU activity have not yet been characterized. It seems that PB may activate multiple nuclear orphan receptors to induce various CYP genes. CYP2B and CYP3A genes appear to be targets for the orphan receptors CAR and PXR, respectively. It is also possible that the pleiotropic effects of PB can, in part, be explained by the ability of the CAR-RXR heterodimer to bind to a variety of nuclear receptor binding motifs. The induction of cytochromes P450 may result in interactions between xenobiotics and in the interference of xenobiotic metabolism and endogenous signalling pathways.

The Ah receptor: Binding specificity only for foreign chemicals?

1984 ◽  
Vol 33 (6) ◽  
pp. 917-924 ◽  
Author(s):  
Daniel W. Nebert ◽  
Howard J. Eisen ◽  
Oliver Hankinson
Keyword(s):  
Receptor Binding ◽  
Binding Specificity ◽  
Ah Receptor ◽  
Receptor Binding Specificity

Effect of Caloric Restriction on the Induction of Hepatic Cytochrome P-450 and AH Receptor Binding in C57BL/6N and DBA/2J Mice

1993 ◽  
Vol 16 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Ming W. Chou ◽  
Rex A. Pegram ◽  
Angelo Turturro ◽  
Robert Holson ◽  
Ronald W. Hart
Keyword(s):  
Caloric Restriction ◽  
Receptor Binding ◽  
Ah Receptor ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome
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