The role of COOH-terminal and acidic domains in the activity and stability of human insulin receptor protein tyrosine kinase studied by purified deletion mutants of the beta subunit domain.

Structural Determinants of Substrate Selection by the Human Insulin-Receptor Protein-Tyrosine Kinase

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1994.tb20077.x ◽

1994 ◽

Vol 226 (2) ◽

pp. 525-536 ◽

Cited By ~ 8

Author(s):

Noeleen E. Keane ◽

Alain Chavanieu ◽

Philip G. Quirk ◽

James S. Evans ◽

Barry A. Levine ◽

...

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Human Insulin ◽

Protein Tyrosine Kinase ◽

Receptor Protein ◽

Substrate Selection ◽

Structural Determinants ◽

Protein Tyrosine ◽

Human Insulin Receptor ◽

Comparative phosphorylation kinetics of the human insulin receptor protein-tyrosine kinase domain and an enzymatically competent deletion construct - the tail could wag the dog

Biochemical Society Transactions ◽

10.1042/bst023188s ◽

1995 ◽

Vol 23 (2) ◽

pp. 188S-188S ◽

Cited By ~ 1

Author(s):

PHILIP G. QUIRK ◽

NOELEEN E. KEANE ◽

BARRY A. LEVINE ◽

LEI WEI ◽

LELAND ELLIS

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Human Insulin ◽

Protein Tyrosine Kinase ◽

Kinase Domain ◽

Receptor Protein ◽

Tyrosine Kinase Domain ◽

Human Insulin Receptor ◽

Kinetics Of

Expression, Characterization, and Crystallization of the Catalytic Core of the Human Insulin Receptor Protein-tyrosine Kinase Domain

Journal of Biological Chemistry ◽

10.1074/jbc.270.14.8122 ◽

1995 ◽

Vol 270 (14) ◽

pp. 8122-8130 ◽

Cited By ~ 78

Author(s):

Lei Wei ◽

Stevan R. Hubbard ◽

Wayne A. Hendrickson ◽

Leland Ellis

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Protein Tyrosine Kinase ◽

Kinase Domain ◽

Receptor Protein ◽

Tyrosine Kinase Domain ◽

Catalytic Core ◽

Human Insulin Receptor ◽

Expression Characterization

Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42456-8 ◽

1992 ◽

Vol 267 (12) ◽

pp. 8383-8389 ◽

Cited By ~ 6

Author(s):

A Cama ◽

M.J. Quon ◽

M de la Luz Sierra ◽

S.I. Taylor

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Tyrosine Kinase ◽

Insulin Action ◽

Kinase Activity ◽

Beta Subunit ◽

Tyrosine Kinase Activity ◽

Receptor Endocytosis ◽

Human Insulin Receptor

Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.87.7.2805 ◽

1990 ◽

Vol 87 (7) ◽

pp. 2805-2809 ◽

Cited By ~ 25

Author(s):

S. R. Wente ◽

M. Villalba ◽

V. L. Schramm ◽

O. M. Rosen

Keyword(s):

Recombinant Protein ◽

Tyrosine Kinase ◽

Insulin Receptor ◽

Human Insulin ◽

Protein Tyrosine Kinase ◽

Binding Properties ◽

Protein Tyrosine ◽

Human Insulin Receptor

Species Specificity of Insulin Binding and Insulin Receptor Protein Tyrosine Kinase Activity*

Endocrinology ◽

10.1210/endo-121-6-2007 ◽

1987 ◽

Vol 121 (6) ◽

pp. 2007-2010 ◽

Cited By ~ 6

Author(s):

RENZO CORDERA ◽

GABRIELLA ANDRAGHETTI ◽

ROBERTO GHERZI ◽

LUCIANO ADEZATI ◽

ANTONIO MONTEMURRO ◽

...

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Protein Tyrosine Kinase ◽

Kinase Activity ◽

Insulin Binding ◽

Species Specificity ◽

Receptor Protein ◽

Tyrosine Kinase Activity ◽

Protein Tyrosine Kinase Activity

Direct modulation of insulin receptor protein tyrosine kinase by vanadate and anti-insulin receptor monoclonal antibodies

Biochemical and Biophysical Research Communications ◽

10.1016/s0006-291x(88)80452-2 ◽

1988 ◽

Vol 152 (3) ◽

pp. 1474-1480 ◽

Cited By ~ 28

Author(s):

Roberto Gherzi ◽

Cinzia Caratti ◽

Gabriella Andraghetti ◽

Stefano Bertolini ◽

Antonio Montemurro ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Tyrosine Kinase ◽

Insulin Receptor ◽

Protein Tyrosine Kinase ◽

Receptor Protein ◽

Protein Tyrosine ◽

Direct Modulation ◽

Methods in Enzymology - Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression ◽

[54] Use of recombinant baculoviruses and 1H nuclear magnetic resonance to study tyrosine phosphorylation by a soluble insulin receptor protein-tyrosine kinase

10.1016/0076-6879(91)00178-y ◽

1991 ◽

pp. 660-669 ◽

Cited By ~ 8

Author(s):

Leland Ellis ◽

Barry A. Levine

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Tyrosine Kinase ◽

Insulin Receptor ◽

Tyrosine Phosphorylation ◽

Protein Tyrosine Kinase ◽

Receptor Protein ◽

1H Nuclear Magnetic Resonance ◽

Soluble Insulin Receptor

How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein‐tyrosine kinase

The FASEB Journal ◽

10.1096/fasebj.9.13.7557015 ◽

1995 ◽

Vol 9 (13) ◽

pp. 1255-1266 ◽

Cited By ~ 118

Author(s):

Susan S. Taylor ◽

Elzbieta Radzio‐Andzelm ◽

Tony Hunter

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Protein Kinases ◽

Protein Tyrosine Kinase ◽

Receptor Protein ◽

Protein Tyrosine ◽

Structural Insights

Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: Molecular yardsticks for analyzing catalytic mechanism and inhibitor design

Bioorganic Chemistry ◽

10.1016/j.bioorg.2005.02.002 ◽

2005 ◽

Vol 33 (4) ◽

pp. 285-297 ◽

Cited By ~ 20

Author(s):

Aliya C. Hines ◽

Keykavous Parang ◽

Ronald A. Kohanski ◽

Stevan R. Hubbard ◽

Philip A. Cole

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Protein Tyrosine Kinase ◽

Catalytic Mechanism ◽

Receptor Protein ◽

Inhibitor Design ◽

Protein Tyrosine ◽