scholarly journals Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages.

1984 ◽  
Vol 259 (18) ◽  
pp. 11305-11311 ◽  
Author(s):  
M E Haberland ◽  
C L Olch ◽  
A M Folgelman
Keyword(s):  
Scavenger Receptor ◽  
Human Monocyte ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Modified Low Density Lipoproteins

scholarly journals Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Fatemeh Moheimani ◽  
Joanne T. M. Tan ◽  
Bronwyn E. Brown ◽  
Alison K. Heather ◽  
David M. van Reyk ◽  
...  
Keyword(s):  
High Glucose ◽  
Lipid Accumulation ◽  
Scavenger Receptor ◽  
Ldl Receptor ◽  
Human Monocyte ◽  
Low Density Lipoproteins ◽  
Receptor Expression ◽  
Low Density ◽  
Cholesteryl Esters ◽  
Protein Levels

During atherosclerosis monocyte-derived macrophages accumulate cholesteryl esters from low-density lipoproteins (LDLs) via lectin-like oxidised LDL receptor-1 (LOX-1) and class AI and AII (SR-AI, SR-AII) and class B (SR-BI, CD36) scavenger receptors. Here we examined the hypothesis that hyperglycaemia may modulate receptor expression and hence lipid accumulation in macrophages. Human monocytes were matured into macrophages in 30 versus 5 mM glucose and receptor expression and lipid accumulation quantified. High glucose elevated LOX1 mRNA, but decreased SR-AI, SR-BI, LDLR, and CD36 mRNA. SR-BI and CD36 protein levels were decreased. Normo- and hyperglycaemic cells accumulated cholesteryl esters from modified LDL to a greater extent than control LDL, but total and individual cholesteryl ester accumulation was not affected by glucose levels. It is concluded that, whilst macrophage scavenger receptor mRNA and protein levels can be modulated by high glucose, these are not key factors in lipid accumulation by human macrophages under the conditions examined.

Role of Atheroma Liposomes and Malondialdehyde-Modified Low-Density Lipoproteins in Complement Activation

Pathobiology ◽  
1996 ◽  
Vol 64 (2) ◽  
pp. 73-78 ◽  
Author(s):  
James M. Sorace ◽  
Sandy Rollins ◽  
Jacinta U. Aniagolu ◽  
Wolfgang J. Mergner ◽  
Katherine Cole ◽  
...  
Keyword(s):  
Complement Activation ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Modified Low Density Lipoproteins

Role of phagocytosis of modified low-density lipoproteins self-associates in pro-inflammatory activation of macrophages.

2021 ◽  
Vol 331 ◽  
pp. e71-e72
Author(s):  
E.E. Bezsonov ◽  
N. Nikiforov ◽  
V.N. Sukhorukov ◽  
V.A. Myasoedova ◽  
A.N. Orekhov
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Modified Low Density Lipoproteins ◽  
Inflammatory Activation
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