scholarly journals A comparison of the heme binding pocket in globins and cytochrome b5.

1975 ◽  
Vol 250 (18) ◽  
pp. 7525-7532
Author(s):  
M G Rossmann ◽  
P Argos
Keyword(s):  
Cytochrome B5 ◽  
Binding Pocket ◽  
Heme Binding

Influences of the hydrophobicity of the heme-binding pocket on the properties and functions of cytochrome b5 mutants

2010 ◽  
Vol 21 (10) ◽  
pp. 1385-1389
Author(s):  
Jian-Hua Gan ◽  
Yun-Hua Wang ◽  
Jian Wu ◽  
Zhong-Xian Huang ◽  
Zong-Xiang Xia
Keyword(s):  
Cytochrome B5 ◽  
Binding Pocket ◽  
Heme Binding

scholarly journals Phospholipid membranes affect tertiary structure of the soluble cytochrome b5 heme-binding domain

2008 ◽  
Vol 1778 (4) ◽  
pp. 1015-1026 ◽  
Author(s):  
Liana V. Basova ◽  
Elisaveta I. Tiktopulo ◽  
Victor P. Kutyshenko ◽  
A. Grant Mauk ◽  
Valentina E. Bychkova
Keyword(s):  
Tertiary Structure ◽  
Cytochrome B5 ◽  
Binding Domain ◽  
Phospholipid Membranes ◽  
Heme Binding

Study on the Gas Phase Stability of Heme-binding Pocket in Cytochrome Tb5 and Its Mutants by Electrospray Mass Spectrometry

2010 ◽  
Vol 20 (12) ◽  
pp. 1540-1545 ◽  
Author(s):  
Chong-Tian Yu ◽  
Yin-Long Guo ◽  
Long Lü ◽  
Yun-Hua Wang ◽  
Ping Yao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Phase Stability ◽  
Electrospray Mass Spectrometry ◽  
Binding Pocket ◽  
Heme Binding

Two Stacked Heme Molecules in the Binding Pocket of the Periplasmic Heme-Binding Protein HmuT from Yersinia pestis

2010 ◽  
Vol 404 (2) ◽  
pp. 220-231 ◽  
Author(s):  
Daniel Mattle ◽  
Antra Zeltina ◽  
Jae-Sung Woo ◽  
Birke A. Goetz ◽  
Kaspar P. Locher
Keyword(s):  
Yersinia Pestis ◽  
Binding Protein ◽  
Binding Pocket ◽  
Heme Binding ◽  
Heme Binding Protein

scholarly journals MAPR origins reveal a new class of prokaryotic cytochrome b5 proteins and possible role in eukaryogenesis

2021 ◽  
Author(s):  
Daniel Tamarit ◽  
Sarah Teakel ◽  
Michealla Marama ◽  
David Aragão ◽  
Svetlana Y. Gerdes ◽  
...  
Keyword(s):  
Family Member ◽  
Membrane Trafficking ◽  
Cytochrome B5 ◽  
Sterol Metabolism ◽  
Heme Binding ◽  
Eukaryotic Evolution ◽  
Multiple Functions ◽  
New Class ◽  
Steroid Responsiveness ◽  
Candidate Phyla Radiation

The multiple functions of PGRMC1, the archetypal heme-binding eukaryotic MAPR family member, include steroidogenic regulation, membrane trafficking, and steroid responsiveness. The interrelationships between these functions are currently poorly understood. Previous work has shown that different MAPR subclasses were present early in eukaryotic evolution, and that tyrosine phosphorylated residues appeared in the eumetazoan ancestor, coincident with a gastrulation organizer. Here we show that MAPR proteins are related to a newly recognized class of prokaryotic cytochrome-b5 domain proteins. Our first solved structure of this new class exhibits shared MAPR-like folded architecture and heme-binding orientation. We also report that a protein subgroup from Candidate Phyla Radiation (CPR) bacteria shares MAPR-like heme-interacting tyrosines. Our results support bacterial origins for both PGRMC1 and CYP51A, that catalyze the meiosis-associated 14-demethylation of the first sterol lanosterol from yeast to humans. We propose that eukaryotic acquisition of a membrane-trafficking function related to sterol metabolism was associated with the appearance of MAPR genes early in eukaryotic evolution.

scholarly journals Amino-acid sequence of the cytochrome-b5-like heme-binding domain from Hansenula anomala flavocytochrome b2

1987 ◽  
Vol 169 (3) ◽  
pp. 539-544 ◽  
Author(s):  
Pierre-Yves HAUMONT ◽  
Marie-Antoinette THOMAS ◽  
Francoise LABEYRIE ◽  
Florence LEDERER
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Cytochrome B5 ◽  
Binding Domain ◽  
Heme Binding ◽  
Flavocytochrome B2 ◽  
Hansenula Anomala

scholarly journals Insertion of the cytochrome b5 heme-binding loop into an SH3 domain. Effects on structure and stability, and clues about the cytochrome's architecture

2008 ◽  
Vol 13 (11) ◽  
pp. 2899-2908 ◽  
Author(s):  
Jane A. Knappenberger ◽  
Christina M. Kraemer-Pecore ◽  
Juliette T.J. Lecomte
Keyword(s):  
Cytochrome B5 ◽  
Sh3 Domain ◽  
Heme Binding ◽  
Structure And Stability ◽  
Binding Loop

scholarly journals Photosynthetic Water Oxidation in Cytochromeb559Mutants Containing a Disrupted Heme-binding Pocket

2001 ◽  
Vol 276 (34) ◽  
pp. 31986-31993 ◽  
Author(s):  
Francisco Morais ◽  
Kristina Kühn ◽  
David H. Stewart ◽  
James Barber ◽  
Gary W. Brudvig ◽  
...  
Keyword(s):  
Water Oxidation ◽  
Binding Pocket ◽  
Heme Binding ◽  
Photosynthetic Water Oxidation
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