scholarly journals Repeated sequence organization and RNA transcription map of the chicken adult beta-globin gene region.

1981 ◽  
Vol 256 (4) ◽  
pp. 1502-1505
Author(s):  
W.I. Wood ◽  
J. Nickol ◽  
G. Felsenfeld
Keyword(s):  
Globin Gene ◽  
Repeated Sequence ◽  
Gene Region ◽  
Beta Globin ◽  
Rna Transcription ◽  
Sequence Organization ◽  
Beta Globin Gene ◽  
Transcription Map

scholarly journals The gamma-delta-beta-globin gene region in G gamma-beta +-hereditary persistence of fetal hemoglobin

Blood ◽  
1982 ◽  
Vol 59 (4) ◽  
pp. 828-831
Author(s):  
JF Balsley ◽  
E Rappaport ◽  
E Schwartz ◽  
S Surrey
Keyword(s):  
Globin Gene ◽  
Blot Hybridization ◽  
Fetal Hemoglobin ◽  
Restriction Enzymes ◽  
Restriction Endonuclease Analysis ◽  
Gene Region ◽  
Beta Globin ◽  
Gamma Delta ◽  
Beta Globin Gene ◽  
Hereditary Persistence

We report restriction endonuclease analysis of the gamma-delta-beta- globin gene region in a mother and child heterozygous for G gamma-beta +-hereditary persistence of fetal hemoglobin (HPFH). The affected chromosome in these persons directs the production of G gamma-chains and beta-chains but not A gamma-chains. DNA was digested with several restriction enzymes and was examined for gamma, delta, beta sequences by blot hybridization. Only normal digestion fragments were present. By sensitive methods, we were unable to detect a deletion in the entire gamma-delta-beta-globin gene region of the affected chromosome, indicating that in this family, G gamma-beta +-HPFH is not due to a large deletion.

scholarly journals An intrachromosomal repeating unit based on DNA bending.

1996 ◽  
Vol 16 (10) ◽  
pp. 5664-5673 ◽  
Author(s):  
Y Wada-Kiyama ◽  
R Kiyama
Keyword(s):  
Genome Rearrangement ◽  
Globin Gene ◽  
Dna Bending ◽  
Active Role ◽  
Gene Region ◽  
Globin Genes ◽  
Beta Globin ◽  
Promoter Regions ◽  
Beta Globin Gene ◽  
Gamma Globin

DNA bending has been observed in conjunction with transcription, replication, and recombination. Furthermore, nucleosomes in eukaryotic cells are positioned through DNA bending, suggesting an active role for DNA bending in the chromosome organization. We reported previously that DNA bend sites appear every 680 bp in the human epsilon- and beta-globin gene regions. Here we showed that these sites are present at an interval of roughly 700 bp in the G gamma-A gamma-psi beta-globin gene region and that they divide the region into units. They were conserved in the promoter regions of nearly all beta-like globin genes and between human beta- and mouse beta maj-globin genes, although the periodicity of the sites was locally disturbed at the junctions of the duplicated G gamma- and A gamma-globin genes and in their second introns. This suggested that the periodicity is ranked lower in the hierarchy of genomic DNA organization than genome rearrangement and gene expression. A close inspection of one of the sites in the A gamma-globin gene region indicated that a 20-bp sequence containing periodic short (dA)n tracts was partly responsible for the bending. This sequence was shown to phase nucleosomes in this region by preferential binding to the core histones.

scholarly journals The repeated sequence (AT)x(T)y upstream to the beta-globin gene is a simple polymorphism [letter]

Blood ◽  
1993 ◽  
Vol 81 (7) ◽  
pp. 1974-1975 ◽  
Author(s):  
R Galanello ◽  
A Meloni ◽  
D Gasperini ◽  
L Saba ◽  
A Cao ◽  
...  
Keyword(s):  
Globin Gene ◽  
Repeated Sequence ◽  
Beta Globin ◽  
Beta Globin Gene

scholarly journals The repeated sequence (AT)x(T)y upstream to the beta-globin gene is a simple polymorphism [letter]

Blood ◽  
1993 ◽  
Vol 81 (7) ◽  
pp. 1974-1975
Author(s):  
R Galanello ◽  
A Meloni ◽  
D Gasperini ◽  
L Saba ◽  
A Cao ◽  
...  
Keyword(s):  
Globin Gene ◽  
Repeated Sequence ◽  
Beta Globin ◽  
Beta Globin Gene
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