scholarly journals Induction of cytoskeletal vimentin and actin gene expression by a tumor-promoting phorbol ester in the human leukemic cell line K562.

1985 ◽  
Vol 260 (6) ◽  
pp. 3868-3874
Author(s):  
P D Siebert ◽  
M Fukuda
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Phorbol Ester ◽  
Leukemic Cell ◽  
Actin Gene ◽  
Leukemic Cell Line ◽  
Human Leukemic Cell ◽  
Human Leukemic Cell Line

scholarly journals Phorbol esters rapidly stimulate amiloride-sensitive Na+/H+ exchange in a human leukemic cell line.

1984 ◽  
Vol 99 (1) ◽  
pp. 340-343 ◽  
Author(s):  
J M Besterman ◽  
P Cuatrecasas
Keyword(s):  
Cell Line ◽  
Phorbol Ester ◽  
Phorbol Esters ◽  
Leukemic Cell ◽  
Leukemic Cell Line ◽  
Human Leukemic Cell ◽  
Initial Event ◽  
Phorbol Ester Receptor ◽  
Human Leukemic Cell Line ◽  
Stimulation Of

The human, leukemic cell line, HL-60, undergoes differentiation in response to tumor-promoting phorbol esters. Recent studies have implicated stimulation of a Na+/H+ antiporter as an initial event in cellular differentiation and/or proliferation. The effects of phorbol esters on Na+-dependent H+ efflux from HL-60 cells were studied by pH-stat titration. Tumor-promoting phorbol diesters, but not the inactive parent alcohol, stimulated Na+-dependent H+ efflux in a rapid (within 1 min at 37 degrees C) and reversible manner. Stimulation was dependent on the concentration of extracellular sodium; lithium could substitute for sodium, but choline could not. Stimulation was dependent on the activity of extracellular protons and was inhibited completely by amiloride. The concentrations of phorbol diesters at which we observed half-maximal stimulation of Na+-dependent H+ efflux are very similar to the Kd reported in the literature for binding of these phorbol diesters to the phorbol ester receptor and the Km for phorbol diester activation of protein kinase C. Overall characterization of basal and phorbol ester-stimulated H+ efflux indicate that stimulation of a Na+/H+ antiporter constitutes a primary event in phorbol ester interaction with HL-60 cells.

Characteristics of 25-Hydroxycholesterol-Induced Apoptosis in the Human Leukemic Cell Line CEM

1997 ◽  
Vol 235 (1) ◽  
pp. 35-47 ◽  
Author(s):  
Sylvette Ayala-Torres ◽  
Peter C. Moller ◽  
Betty H. Johnson ◽  
E.Brad Thompson
Keyword(s):  
Cell Line ◽  
Leukemic Cell ◽  
Leukemic Cell Line ◽  
Human Leukemic Cell ◽  
Human Leukemic Cell Line ◽  
Induced Apoptosis

scholarly journals presence of acetylcholine in human leukemic cell line (HSB.2).

1994 ◽  
Vol 64 ◽  
pp. 145
Author(s):  
Takanori Tsuchiya ◽  
Takeshi Fujii ◽  
Kazuko Fujimoto ◽  
Takeshi Suzuki ◽  
Tadashi Kasahara ◽  
...  
Keyword(s):  
Cell Line ◽  
Leukemic Cell ◽  
Leukemic Cell Line ◽  
Human Leukemic Cell ◽  
Human Leukemic Cell Line

Modulation of the Effects of Osteoprotegerin (OPG) Ligand in a Human Leukemic Cell Line by OPG and Calcitonin

2000 ◽  
Vol 279 (2) ◽  
pp. 391-397 ◽  
Author(s):  
L. Mancini ◽  
N. Moradi-Bidhendi ◽  
M.L. Brandi ◽  
M. Perretti ◽  
I. MacIntyre
Keyword(s):  
Cell Line ◽  
Leukemic Cell ◽  
Leukemic Cell Line ◽  
Human Leukemic Cell ◽  
Human Leukemic Cell Line

Heterogeneity of Binding Sites and Bioeffects of Raloxifene on the Human Leukemic Cell Line FLG 29.1

1997 ◽  
Vol 240 (3) ◽  
pp. 573-579 ◽  
Author(s):  
Gianna Fiorelli ◽  
Valentina Martineti ◽  
Francesca Gori ◽  
Susanna Benvenuti ◽  
Uliana Frediani ◽  
...  
Keyword(s):  
Cell Line ◽  
Binding Sites ◽  
Leukemic Cell ◽  
Leukemic Cell Line ◽  
Human Leukemic Cell ◽  
Human Leukemic Cell Line
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