scholarly journals In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis.

1979 ◽  
Vol 254 (17) ◽  
pp. 8163-8168 ◽  
Author(s):  
J.D. McGarry ◽  
D.W. Foster
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Hepatic Fatty Acid ◽  
Carnitine Acyltransferase ◽  
Malonyl Coa ◽  
Hepatic Fatty Acid Oxidation

scholarly journals Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis

2021 ◽  
pp. 101275
Author(s):  
Marina Serrano-Maciá ◽  
Jorge Simón ◽  
Maria J. González-Rellan ◽  
Mikel Azkargorta ◽  
Naroa Goikoetxea-Usandizaga ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Hepatic Fatty Acid ◽  
Hepatic Fatty Acid Oxidation

scholarly journals Agmatine Stimulates Hepatic Fatty Acid Oxidation

2006 ◽  
Vol 281 (13) ◽  
pp. 8486-8496 ◽  
Author(s):  
Itzhak Nissim ◽  
Yevgeny Daikhin ◽  
Ilana Nissim ◽  
Bohdan Luhovyy ◽  
Oksana Horyn ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Hepatic Fatty Acid ◽  
Hepatic Fatty Acid Oxidation

scholarly journals Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I

1983 ◽  
Vol 212 (2) ◽  
pp. 521-524 ◽  
Author(s):  
T W Stephens ◽  
G A Cook ◽  
R A Harris
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Intracellular Ph ◽  
Carnitine Palmitoyltransferase ◽  
Acid Oxidation ◽  
Effect Of Ph ◽  
Malonyl Coa ◽  
Carnitine Palmitoyltransferase I ◽  
Ph Dependent ◽  
Hepatic Fatty Acid Oxidation

Malonyl-CoA inhibition of carnitine palmitoyltransferase I was found to be very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 microM respectively. It is suggested that a lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensitivity of carnitine palmitoyltransferase I.

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