Effects of working memory deficits on the communicative functioning of Alzheimer’s dementia patients

2003 ◽  
Vol 36 (3) ◽  
pp. 209-219 ◽  
Author(s):  
Kathryn A. Bayles
2015 ◽  
Vol 9 (3) ◽  
pp. 301-305 ◽  
Author(s):  
Roy P.C. Kessels ◽  
Anouk Overbeek ◽  
Zita Bouman

In addition to episodic memory impairment, working memory may also be compromised in mild cognitive impairment (MCI) or Alzheimer's dementia (AD), but standard verbal and visuospatial span tasks do not always detect impairments. Objective: To examine whether more complex verbal and visuospatial working memory tasks result in more reliable impairment detection. Methods: The Digit Span (forward, backward and sequencing), Spatial Span (forward and backward) and Spatial Addition test from the Wechsler batteries were administered to MCI and AD patients and performance compared to healthy older adult controls. Results: Results showed that both the MCI and AD patients had impaired performance on the Spatial Addition test. Both groups also had impaired performance on all three Digit Span conditions, but no differences were found between forward and backward conditions in any of the groups. The sequencing condition differed from the backward condition only in the AD group. Spatial Span performance was impaired in AD group patients but not in MCI patients. Conclusion: Working memory deficits are evident in MCI and AD even on standard neuropsychological tests. However, available tests may not detect subtle impairments, especially in MCI. Novel paradigms tapping the episodic buffer component of working memory may be useful in the assessment of working memory deficits, but such instruments are not yet available for clinical assessment.


2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 1095-1095
Author(s):  
Y. Matsui ◽  
R. Fujita ◽  
A. Harada ◽  
T. Sakurai ◽  
T. Nemoto ◽  
...  

1993 ◽  
Vol 2 (2) ◽  
pp. 160-175 ◽  
Author(s):  
Mary Lucero ◽  
Sally Hutchinson ◽  
Sue Leger-Krall ◽  
Holly Skodol Wilson

2021 ◽  
Vol 3 ◽  
Author(s):  
Amit Meghanani ◽  
C. S. Anoop ◽  
Angarai Ganesan Ramakrishnan

Alzheimer’s dementia (AD) is a type of neurodegenerative disease that is associated with a decline in memory. However, speech and language impairments are also common in Alzheimer’s dementia patients. This work is an extension of our previous work, where we had used spontaneous speech for Alzheimer’s dementia recognition employing log-Mel spectrogram and Mel-frequency cepstral coefficients (MFCC) as inputs to deep neural networks (DNN). In this work, we explore the transcriptions of spontaneous speech for dementia recognition and compare the results with several baseline results. We explore two models for dementia recognition: 1) fastText and 2) convolutional neural network (CNN) with a single convolutional layer, to capture the n-gram-based linguistic information from the input sentence. The fastText model uses a bag of bigrams and trigrams along with the input text to capture the local word orderings. In the CNN-based model, we try to capture different n-grams (we use n = 2, 3, 4, 5) present in the text by adapting the kernel sizes to n. In both fastText and CNN architectures, the word embeddings are initialized using pretrained GloVe vectors. We use bagging of 21 models in each of these architectures to arrive at the final model using which the performance on the test data is assessed. The best accuracies achieved with CNN and fastText models on the text data are 79.16 and 83.33%, respectively. The best root mean square errors (RMSE) on the prediction of mini-mental state examination (MMSE) score are 4.38 and 4.28 for CNN and fastText, respectively. The results suggest that the n-gram-based features are worth pursuing, for the task of AD detection. fastText models have competitive results when compared to several baseline methods. Also, fastText models are shallow in nature and have the advantage of being faster in training and evaluation, by several orders of magnitude, compared to deep models.


2015 ◽  
Vol 36 (3) ◽  
pp. 1245-1252 ◽  
Author(s):  
Jennifer L. Whitwell ◽  
David T. Jones ◽  
Joseph R. Duffy ◽  
Edythe A. Strand ◽  
Mary M. Machulda ◽  
...  

2014 ◽  
Vol 22 (3) ◽  
pp. S124
Author(s):  
Ozlem Erden Aki ◽  
Yildiz Kaya ◽  
Sedat Isikli ◽  
Seda Kibaroglu ◽  
Eda Derle Ciftci ◽  
...  

2008 ◽  
Vol 29 (10) ◽  
pp. 1474-1484 ◽  
Author(s):  
Úrsula Muñoz ◽  
Fernando Bartolomé ◽  
Félix Bermejo ◽  
Ángeles Martín-Requero

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