ELISA for a complexed antigen with a monoclonal antibody blocking reaction with the free antigen—assay-specific for complexed prostate-specific antigen

2000 ◽  
Vol 234 (1-2) ◽  
pp. 99-106 ◽  
Author(s):  
Kyoichi Matsumoto ◽  
Noboru Konishi ◽  
Tomohiro Samori ◽  
Emi Kimura ◽  
Michiko Doi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Antigen Assay ◽  
Free Antigen

Monoclonal antibody to the prostate specific antigen: Monoklonaler Antikörper gegen das Prostata-spezifische Antigen

Andrologia ◽  
2009 ◽  
Vol 22 (S1) ◽  
pp. 44-55
Author(s):  
F. Donn ◽  
T. Bruns ◽  
L. Meyerrinck ◽  
C. Augustin ◽  
M. Schulz ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Monoklonaler Antikörper

PD53-07 CLINICAL SIGNIFICANCE OF THE SIAα2,3GAL-GLYCOSYLATED PROSTATE-SPECIFIC ANTIGEN ASSAY FOR PROSTATE CANCER DETECTION

2020 ◽  
Vol 203 ◽  
pp. e1099
Author(s):  
Tohru Yoneyama* ◽  
Yuki Tobisawa ◽  
Tomokazu Ishikawa ◽  
Shingo Hatakeyama ◽  
Kazuyuki Mori ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Clinical Significance ◽  
Cancer Detection ◽  
Specific Antigen ◽  
Prostate Cancer Detection ◽  
Antigen Assay

scholarly journals Efficiency of Ultrasensitive Prostate-specific Antigen Assay in Diagnosing Biochemical Failure After Radical Prostatectomy

2007 ◽  
Vol 37 (6) ◽  
pp. 446-451 ◽  
Author(s):  
Fumitaka Shimizu ◽  
Shiro Tanaka ◽  
Yutaka Matsuyama ◽  
Takashi Tominaga ◽  
Yasuo Ohashi ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Biochemical Failure ◽  
Antigen Assay

scholarly journals Clinical significance of the Lacdi NA c‐glycosylated prostate‐specific antigen assay for prostate cancer detection

2019 ◽  
Vol 110 (8) ◽  
pp. 2573-2589 ◽  
Author(s):  
Tohru Yoneyama ◽  
Yuki Tobisawa ◽  
Tomonori Kaneko ◽  
Takatoshi Kaya ◽  
Shingo Hatakeyama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Clinical Significance ◽  
Cancer Detection ◽  
Specific Antigen ◽  
Prostate Cancer Detection ◽  
Antigen Assay

An ultrasensitive aptasensor for prostate specific antigen assay based on Exonuclease T-aided cyclic cleavage

2018 ◽  
Vol 61 (4) ◽  
pp. 393-396
Author(s):  
Guangxing Liu ◽  
Tian Zhang ◽  
Yuguo Tang ◽  
Peng Miao
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Antigen Assay

scholarly journals Novel immunoassay for the measurement of complexed prostate-specific antigen in serum

1998 ◽  
Vol 44 (6) ◽  
pp. 1216-1223 ◽  
Author(s):  
W Jeffrey Allard ◽  
Zeqi Zhou ◽  
Kwok K Yeung
Keyword(s):  
Prostate Cancer ◽  
Monoclonal Antibody ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Binding Properties ◽  
Prostate Disease ◽  
Free Psa ◽  
Total Psa ◽  
Benign Prostate ◽  
Artificial Mixtures

Abstract Serum prostate-specific antigen (PSA) is an effective diagnostic tool for detection of prostate cancer (CaP) at an early and potentially curable stage, but specificity is low. Studies have shown that the proportion of serum PSA complexed with α-1-antichymotrypsin (ACT) is higher in men with CaP than in men with benign prostate disease. We developed a novel immunoassay for complexed PSA based on the unique binding properties of a monoclonal antibody that fails to bind free PSA in the presence of antibodies specific for free PSA. The assay measured mixtures of free and complexed PSA accurately, and the measured values of free + complexed PSA in artificial mixtures and in patient sera were equivalent to the measured value of total PSA. Both the serum concentration and the proportion of complexed PSA was substantially higher in patients with CaP compared with patients with benign prostate disease. The cPSA assay may have utility in improving specificity in screening for prostate cancer.

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