The effect of swimming exercise on ventricular fibrillation threshold and spontaneous defibrillation in isolated perfused rat heart

1988 ◽  
Vol 20 (2) ◽  
pp. II-II
Author(s):  
M ARAD ◽  
S ROGEL ◽  
Y MAHLER ◽  
G URETZKY
Keyword(s):  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Swimming Exercise ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Ventricular Fibrillation Threshold ◽  
Spontaneous Defibrillation

The effect of hexane on the ventricular fibrillation threshold of the isolated perfused rat heart

Toxicology ◽  
1992 ◽  
Vol 71 (1-2) ◽  
pp. 145-150 ◽  
Author(s):  
Shaun M. Khedun ◽  
Breminand Maharaj ◽  
William P. Leary ◽  
Cecil J. Lockett
Keyword(s):  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Ventricular Fibrillation Threshold

Protective effects of an adenosine deaminase inhibitor on ischemia-reperfusion injury in isolated perfused rat heart

1990 ◽  
Vol 259 (3) ◽  
pp. H835-H838 ◽  
Author(s):  
Q. Y. Zhu ◽  
S. G. Chen ◽  
C. M. Zou
Keyword(s):  
Ventricular Fibrillation ◽  
Reperfusion Injury ◽  
Adenosine Deaminase ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Treated Group ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Resting Tension

We tested the effect of the adenosine deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)adenosine (EHNA) on ischemia-reperfusion injury in isolated perfused rat heart. In the ischemia-reperfusion group (n = 10), ventricular fibrillation occurred within 3 min of reperfusion after the 40-min ischemic period. The incidence of ventricular fibrillation was 90% with a mean duration of 3.15 +/- 0.97 (SE) min. Resting tension increased significantly. By contrast, the incidence of ventricular fibrillation after reperfusion in the EHNA-treated (5 microM) group (n = 10) was 20% (P less than 0.01), and the duration was 0.30 +/- 0.21 min (P less than 0.01). Resting tension was significantly lower and around the normal level in the EHNA-treated group (P less than 0.01). Contraction amplitude and heart rate recovered to nearly normal compared with the ischemia-reperfusion group (P less than 0.01). Coronary flow was greater in the EHNA-treated group (P less than 0.01). It is concluded that EHNA protects the heart, possibly by accumulation of adenosine that benefits the hearts and by blocking the xanthine oxidase pathway for free radical generation.

Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart

1979 ◽  
Vol 43 (3) ◽  
pp. 533-540 ◽  
Author(s):  
W.F. Lubbe ◽  
M.L. McFadyen ◽  
C.A. Muller ◽  
M. Worthington ◽  
L.H. Opie
Keyword(s):  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Protective Action ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart
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