Replacement recombination events targeted at immunoglobulin heavy chain DNA sequences in mouse myeloma cells

1990 ◽  
Vol 213 (3) ◽  
pp. 415-435 ◽  
Author(s):  
A.J.H. Smith ◽  
B. Kalogerakis
Keyword(s):  
Heavy Chain ◽  
Dna Sequences ◽  
Immunoglobulin Heavy Chain ◽  
Myeloma Cells ◽  
Mouse Myeloma

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer

1987 ◽  
Vol 7 (7) ◽  
pp. 2558-2567
Author(s):  
J L Imler ◽  
C Lemaire ◽  
C Wasylyk ◽  
B Wasylyk
Keyword(s):  
Heavy Chain ◽  
Promoter Activity ◽  
Tissue Specificity ◽  
Simian Virus 40 ◽  
Immunoglobulin Heavy Chain ◽  
Regulatory Elements ◽  
Simian Virus ◽  
Negative Regulation ◽  
Heterologous Promoter ◽  
Myeloma Cells

We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.

scholarly journals Construction of recombinant plasmids containing Xenopus immunoglobulin heavy chain DNA sequences.

1981 ◽  
Vol 78 (3) ◽  
pp. 1755-1759 ◽  
Author(s):  
R. D. Brown ◽  
R. W. Armentrout ◽  
M. D. Cochran ◽  
J. Cappello ◽  
S. O. Langemeier
Keyword(s):  
Heavy Chain ◽  
Dna Sequences ◽  
Immunoglobulin Heavy Chain ◽  
Recombinant Plasmids

DNA Sequences of the Immunoglobulin Heavy Chain Variable Region Gene in Pyothorax-Associated Lymphoma

Oncology ◽  
2002 ◽  
Vol 62 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Hideaki Miwa ◽  
Tetsuya Takakuwa ◽  
Shin-ichi Nakatsuka ◽  
Yasuhiko Tomita ◽  
Keiji Iuchi ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Dna Sequences ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Region Gene ◽  
Heavy Chain Variable Region ◽  
Variable Region Gene

scholarly journals Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

1987 ◽  
Vol 7 (7) ◽  
pp. 2558-2567 ◽  
Author(s):  
J L Imler ◽  
C Lemaire ◽  
C Wasylyk ◽  
B Wasylyk
Keyword(s):  
Heavy Chain ◽  
Promoter Activity ◽  
Tissue Specificity ◽  
Simian Virus 40 ◽  
Immunoglobulin Heavy Chain ◽  
Regulatory Elements ◽  
Simian Virus ◽  
Negative Regulation ◽  
Heterologous Promoter ◽  
Myeloma Cells

We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.

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