Isolated single umbilical artery anomaly and the risk for congenital malformations: A meta-analysis

1998 ◽  
Vol 33 (4) ◽  
pp. 580-585 ◽  
Author(s):  
Maheshwar R Thummala ◽  
Tonse N.K Raju ◽  
Patricia Langenberg
Keyword(s):  
Congenital Malformations ◽  
Umbilical Artery ◽  
Meta Analysis ◽  
Single Umbilical Artery

Association of Single Umbilical Artery with Congenital Malformations of Vascular Etiology

1998 ◽  
Vol 1 (6) ◽  
pp. 487-493 ◽  
Author(s):  
Petros M. Pavlopoulos ◽  
Anastasia E. Konstantinidou ◽  
Emmanuel Agapitos ◽  
Constantinos N. Christodoulou ◽  
Panagiotis Davaris
Keyword(s):  
Congenital Malformations ◽  
Umbilical Artery ◽  
Organ System ◽  
Single Umbilical Artery ◽  
Umbilical Vessels ◽  
Limb Reduction ◽  
Renal Aplasia

The possible association of a single umbilical artery (SUA) with malformations of vascular etiology is investigated in this study. Four hundred twelve fetal and embryonic autopsies showing one or more congenital malformations, collected over 7 years, were reviewed. Microscopic confirmation of a SUA was evident in 20 cases (4.85%). The two subgroups with 2 ( nA = 20) or 3 umbilical vessels ( nB = 392) were compared with each other, in relation to the frequency of malformations per organ system. In the group of fetuses with congenital malformations, no association was observed between SUA and the incidence of CNS, cardiac, pulmonary, or genital malformations. However, there was a significantly higher incidence of atresia of hollow organs ( P = 0.003), renal aplasia ( P = 0.034), and limb reduction defects (LRD) ( P = 0.0383) when only a single umbilical artery was present. This suggests a possible etiopathogenetic association of SUA with congenital malformations of vascular etiology. Furthermore, the findings of our study suggest that prenatal identification of a SUA warrants a thorough search for atresias, renal aplasia, and LRD-type malformations.

Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Themistoklis Dagklis ◽  
Antonios Siargkas ◽  
Aikaterini Apostolopoulou ◽  
Ioannis Tsakiridis ◽  
Apostolos Mamopoulos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prenatal Diagnosis ◽  
Umbilical Artery ◽  
Meta Analysis ◽  
Perinatal Outcomes ◽  
Current Evidence ◽  
Cochrane Library ◽  
Single Umbilical Artery ◽  
Increased Risk ◽  
Singleton Pregnancies

Abstract Objectives A systematic review and meta-analysis was conducted to quantitatively synthesize the current evidence on the association of prenatally diagnosed isolated single umbilical artery (iSUA) in singleton pregnancies with small for gestational age (SGA) neonates and other perinatal outcomes. Methods A search of PubMed/Medline, Scopus and The Cochrane Library was conducted, from inception to February 2021, in order to identify studies comparing the risk of SGA and other perinatal adverse outcomes in prenatally diagnosed iSUA singleton pregnancies vs. those with a 3-vessel cord (3VC). The quality of eligible studies was assessed according to the improved Newcastle–Ottawa Scale (NOS). The heterogeneity of results across the studies was tested using the I2 test. Funnel plots and Egger’s test were used to assess the possibility of publication bias. Prospero RN: CRD42020182586. Results The electronic search identified 7,605 studies, of which 11 were selected, including three retrospective cohort and eight retrospective case control studies, overall reporting on 1,533 iSUA cases. The risk of delivering SGA neonates was increased in cases with iSUA (OR: 2.90; 95% CI: 2.02–4.18; p<0.00001; I2=71%). Similarly, iSUA was associated with an increased risk of pregnancy-induced hypertension (PIH) (OR: 2.23; 95% CI: 1.41–3.54; p<0.000; I2=1%), intrauterine death (IUD) (OR: 2.62; 95% CI: 1.43–4.79; p=0.002; I2=0%), preterm birth (PTB) (OR: 2.48; 95% CI: 1.73–3.56; p<0.00001; I2=56%), cesarean section (CS) (OR: 1.64; 95% CI: 1.11–2.41; p=0.01; I2=78%) and admission to neonatal intensive care unit (NICU) (OR: 2.28; 95% CI: 1.52–3.44; p<0.000001; I2=73%). Conclusions In prenatally diagnosed iSUA there is a higher risk of SGA, PIH, IUD, PTB, CS and NICU admission. These findings support the value of prenatal diagnosis of iSUA, which may subsequently intensify surveillance for the detection of specific pregnancy complications.

scholarly journals Association Between Isolated Single Umbilical Artery and Perinatal Outcomes: A Meta-Analysis

2016 ◽  
Vol 22 ◽  
pp. 1451-1459 ◽  
Author(s):  
Yajuan Xu ◽  
Lidan Ren ◽  
Shanshan Zhai ◽  
Xiaohua Luo ◽  
Teng Hong ◽  
...  
Keyword(s):  
Umbilical Artery ◽  
Meta Analysis ◽  
Perinatal Outcomes ◽  
Single Umbilical Artery

Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta-analysis

2013 ◽  
Vol 42 (6) ◽  
pp. 622-628 ◽  
Author(s):  
B. J. Voskamp ◽  
H. Fleurke-Rozema ◽  
K. Oude-Rengerink ◽  
R. J. M. Snijders ◽  
C. M. Bilardo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Perinatal Mortality ◽  
Fetal Growth ◽  
Umbilical Artery ◽  
Meta Analysis ◽  
Single Umbilical Artery ◽  
Relationship Of

scholarly journals Congenital Malformations Associated With a Single Umbilical Artery in Twin Pregnancies

2015 ◽  
Vol 18 (5) ◽  
pp. 595-600 ◽  
Author(s):  
Sarah E. Mitchell ◽  
Karen Reidy ◽  
Fabricio Da Silva Costa ◽  
Ricardo Palma-Dias ◽  
Thomas J. Cade ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Congenital Malformations ◽  
Twin Pregnancy ◽  
Umbilical Artery ◽  
Associated Anomalies ◽  
Fetal Anomalies ◽  
Single Umbilical Artery ◽  
Twin Pregnancies

A single umbilical artery (SUA) was identified in 1.5% of twin pregnancies. The presence of a SUA in a twin pregnancy was associated with a 50% incidence of fetal anomalies, many of them complex and severe. The embryology and pathophysiological mechanisms associated with a SUA are reviewed. Aneuploidy is relatively common and should be considered, particularly in the presence of associated anomalies. Fetal growth restriction is frequent and preterm delivery is common.

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