Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains

2000 ◽  
Vol 172 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Megumi Takahashi ◽  
Eizo Iseki ◽  
Kenji Kosaka
Keyword(s):  
Neurofibrillary Tangles ◽  
Early Stage ◽  
Alzheimer Type ◽  
Alzheimer Type Dementia

Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia

1990 ◽  
Vol 537 (1-2) ◽  
pp. 318-322 ◽  
Author(s):  
Haruyasu Yamaguchi ◽  
Koji Ishiguro ◽  
Mikio Shoji ◽  
Tsuneo Yamazaki ◽  
Yoichi Nakazato ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Amyloid Β ◽  
Alzheimer Type ◽  
Protein Precursor ◽  
Alzheimer Type Dementia

Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia

1991 ◽  
Vol 81 (6) ◽  
pp. 603-609 ◽  
Author(s):  
H. Yamaguchi ◽  
Y. Nakazato ◽  
T. Kawarabayashi ◽  
K. Ishiguro ◽  
Y. Ihara ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Alzheimer Type ◽  
Neuropil Threads ◽  
Alzheimer Type Dementia

scholarly journals The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia

2019 ◽  
Vol 26 (6) ◽  
pp. 596-606
Author(s):  
Janet M. Duchek ◽  
Andrew J. Aschenbrenner ◽  
Anne M. Fagan ◽  
Tammie L.S. Benzinger ◽  
John C. Morris ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Early Stage ◽  
Hippocampal Volume ◽  
Alzheimer Type ◽  
Cognitively Normal ◽  
Informant Ratings ◽  
Alzheimer Type Dementia ◽  
The Relationship ◽  
Behavioral Markers ◽  
Normal Controls

AbstractObjectives:The present study explored relationships among personality, Alzheimer’s disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion?Methods:Both self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aβ42, and CSF tau.Results:Higher neuroticism, lower conscientiousness, along with all four biomarkers strongly discriminated cognitively normal controls from early-stage AD individuals. The direct effects of neuroticism and conscientiousness were only mediated by hippocampal volume. Conscientiousness along with all biomarkers predicted conversion from healthy aging to early-stage AD; however, none of the biomarkers mediated the relationship between conscientiousness and conversion. Conscientiousness predicted conversion as strongly as the biomarkers, with the exception of hippocampal volume.Conclusions:Conscientiousness and to a lesser extent neuroticism serve as important independent behavioral markers for AD risk.

Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia

2012 ◽  
Vol 47 (8) ◽  
pp. 625-630 ◽  
Author(s):  
M.C. Puertas ◽  
J.M. Martínez-Martos ◽  
M.P. Cobo ◽  
M.P. Carrera ◽  
M.D. Mayas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Early Stage ◽  
Alzheimer Type ◽  
Men And Women ◽  
Oxidative Stress Parameters ◽  
Alzheimer Type Dementia ◽  
Stress Parameters

Neurofibrillary tangles, but not Alzheimer-type pathology, in a young boxer

1996 ◽  
Vol 22 (1) ◽  
pp. 12-16 ◽  
Author(s):  
J. F. Geddes ◽  
G. H. Vowles ◽  
S. F. D. Robinson ◽  
J. C. Sutcliffe
Keyword(s):  
Neurofibrillary Tangles ◽  
Alzheimer Type
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