The relationship between formation of senile plaques and neurofibrillary tangles and changes in nerve cell metabolism in Alzheimer type dementia

The relationship between plasma homocysteine and behavioral and psychological symptoms of dementia (BPSD) has not been specifically investigated in previous research. In this study, we compared plasma homocysteine (Hcy) among 40 Alzheimer’s disease (AD) patients with BPSD, 37 AD patients without BPSD, and 39 healthy controls. Our results evidenced that the plasma homocysteine levels in AD patients with BPSD and without BPSD were higher than healthy controls and that the plasma homocysteine concentration in AD patients with BPSD was the highest among the three groups. Significant correlation between plasma homocysteine concentration and cognitive decline and duration of dementia was observed, but there was no correlation between BPSD and cognitive dysfunction or duration of dementia. In conclusion, this study showed for the first time that BPSD were associated with plasma homocysteine concentration in Alzheimer's dementia, and the results supported that hyperhomocysteine may take part in the pathogenesis of BPSD.

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FORM AND DISTRIBUTION OF SENILE PLAQUES SEEN IN SILVER IMPREGNATED SECTIONS IN THE BRAINS OF INTELLECTUALLY NORMAL ELDERLY PEOPLE AND PEOPLE WITH ALZHEIMER-TYPE DEMENTIA

Neuropathology and Applied Neurobiology ◽

10.1111/j.1365-2990.1983.tb00123.x ◽

1983 ◽

Vol 9 (5) ◽

pp. 379-389 ◽

Cited By ~ 50

Author(s):

P. H. GIBSON

Keyword(s):

Elderly People ◽

Senile Plaques ◽

Alzheimer Type ◽

Alzheimer Type Dementia

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Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia

Brain Research ◽

10.1016/0006-8993(90)90377-n ◽

1990 ◽

Vol 537 (1-2) ◽

pp. 318-322 ◽

Cited By ~ 29

Author(s):

Haruyasu Yamaguchi ◽

Koji Ishiguro ◽

Mikio Shoji ◽

Tsuneo Yamazaki ◽

Yoichi Nakazato ◽

...

Keyword(s):

Neurofibrillary Tangles ◽

Amyloid Β ◽

Alzheimer Type ◽

Protein Precursor ◽

Alzheimer Type Dementia

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Alzheimer's dementia, cognitive impairment and decision making

European Journal of Investigation in Health, Psychology and Education ◽

10.1989/ejihpe.v1i1.2 ◽

2011 ◽

Vol 1 (1) ◽

pp. 17-29

Author(s):

Aurora Moreno ◽

José R. Alameda

Keyword(s):

Decision Making ◽

Screening Test ◽

Iowa Gambling Task ◽

Cognitive Status ◽

Alzheimer Type ◽

Alzheimer Type Dementia ◽

Initial Stage ◽

Strategy Pattern ◽

The Relationship ◽

Card Test

This study aims to know about how is the decision making in Alzheimer Type Dementia (ATD) the target is to see if the tendency at risk appears or not, and the relationship between performance and the cognitive status in each of the areas evaluated by the screening test for dementia cognitive. Ten ATD patients participated in this experiment, compared with ten control subjects. A Card Test (based on the Iowa Gambling Task) was used. Subjects had to choose among different options that implied more or less risk. Furthermore, a screening test was used. The results reflected the fact that subjects with ATD in an initial stage showed a tendency to risk in decision making and they did not develop any election strategy pattern. It seems that the way in which patients make their decisions is related to the cognitive damage and the degree in which Alzheimer affects the different brain areas.

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