scholarly journals Evaluation of cerebral metabolism and quantitative electroencephalography after hypothermic circulatory, arrest and low-flow cardiopulmonary bypass at different temperatures

1994 ◽  
Vol 107 (4) ◽  
pp. 1006-1019 ◽  
Author(s):  
Craig K. Mezrow ◽  
Peter S. Midulla ◽  
Ali M. Sadeghi ◽  
Alejandro Gandsas ◽  
Weijia Wang ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Cerebral Metabolism ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Low Flow ◽  
Quantitative Electroencephalography ◽  
Different Temperatures

A Comparison of the Perioperative Neurologic Effects of Hypothermic Circulatory Arrest versus Low-Flow Cardiopulmonary Bypass in Infant Heart Surgery

1993 ◽  
Vol 329 (15) ◽  
pp. 1057-1064 ◽  
Author(s):  
Jane W. Newburger ◽  
Richard A. Jonas ◽  
Gil Wernovsky ◽  
David Wypij ◽  
Paul R. Hickey ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Heart Surgery ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Low Flow

A vulnerable interval for cerebral injury—comparison of hypothermic circulatory arrest and low flow cardiopulmonary bypass

1993 ◽  
Vol 3 (3) ◽  
pp. 287-298 ◽  
Author(s):  
Craig K. Mezrow ◽  
Peter S. Midulla ◽  
Ali M. Sadeghi ◽  
Otto Dapunt ◽  
Alejandro Gandsas ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiopulmonary Bypass ◽  
Congenital Heart ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Cerebral Injury ◽  
Low Flow ◽  
Increasing Risk ◽  
Hypothermic Arrest

Over the past two decades, advances in equipment used for cardiopulmonary bypass and in operative techniques have resulted in a tremendous decrease in the mortality of patients undergoing surgical repair of congenital heart disease utilizing hypothermic circulatory arrest. Despite the widespread use of hypothermic arrest, opinion is not unanimous with regard to its safety. Previous studies which have examined neurological outcome following repair of congenital heart disease in infancy have generally agreed that when the period of arrest exceeds 60 minutes, there is increasing risk of cerebral injury.

Cerebral effects of low-flow cardiopulmonary bypass and hypothermic circulatory arrest

1994 ◽  
Vol 57 (3) ◽  
pp. 532-539 ◽  
Author(s):  
Craig K. Mezrow ◽  
Ali M. Sadeghi ◽  
Alejandro Gandsas ◽  
Otto E. Dapunt ◽  
Howard H. Shiang ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Low Flow

Developmental and Neurologic Status of Children after Heart Surgery with Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass

1995 ◽  
Vol 332 (9) ◽  
pp. 549-555 ◽  
Author(s):  
David C. Bellinger ◽  
Richard A. Jonas ◽  
Leonard A. Rappaport ◽  
David Wypij ◽  
Gil Wernovsky ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Heart Surgery ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Low Flow ◽  
Neurologic Status

Laboratory studies regarding regional low-flow perfusion for neonatal cardiac surgery

2005 ◽  
Vol 15 (S1) ◽  
pp. 134-141 ◽  
Author(s):  
William M. DeCampli
Keyword(s):  
Cardiopulmonary Bypass ◽  
Circulatory Arrest ◽  
Deep Hypothermic Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Low Flow ◽  
Flow Perfusion ◽  
Neonatal Cardiac Surgery ◽  
The Central Nervous System ◽  
And Performance ◽  
Performance Intelligence Quotient

As the overall mortality declines following repair of complex congenital cardiac malformations, attention has focused on reducing the lasting morbidity of these interventions, particularly the observed neurodevelopmental deficiencies. Both cardiopulmonary bypass and deep hypothermic circulatory arrest produce transient alterations in cerebral hemodynamics and metabolism. In studies performed in animals, deep hypothermic circulatory arrest, as compared to cardiopulmonary bypass alone, has been shown to produce excess injury to, and death of, neuronal and glial cells.1 In neonates, deep hypothermic circulatory arrest of greater duration than one hour is a risk factor for early post-operative seizures, and for subsequent neurodevelopmental deficits.2 The Boston Circulatory Arrest Study suggests that, at follow-up of eight years, infants subjected to greater than 41 minutes of deep hypothermic circulatory arrest had excess deficits in full-scale, verbal and performance intelligence quotient, the Mayo apraxia test, and grooved pegboard testing.3 The independent adverse effects of deep hypothermic circulatory arrest have encouraged clinicians to develop the alternative technique of intermittent global perfusion, or continuous regional perfusion at low flow perfusion, in an attempt to reduce the degree of injury to the central nervous system.4–7

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