Bacterial Infections in Patients With Chronic Renal Failure: Occurrence With Spinal Cord injury

AbstractBacterial infections are the leading cause of death in people with a spinal cord injury (SCI). Bacteriophages (phages) are viruses that solely infect and kill bacteria. The idea of using phages to treat bacterial infections, i.e., phage therapy, is very promising and potentially allows a more specific and personalized treatment of bacterial infections than antibiotics. While multi-drug resistant infections affect individuals from the general population, alternative therapeutic options are especially warranted in high-risk populations, such as individuals with SCI. However, more clinical data must be collected before phage therapy can be implemented in clinical practice, with numerous possible, subsequent applications.

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The prognosis for end-stage renal failure in spinal cord injury and spina bifida - Australia and New Zealand, 1970-1991*

Australian and New Zealand Journal of Medicine ◽

10.1111/j.1445-5994.1994.tb04423.x ◽

1994 ◽

Vol 24 (1) ◽

pp. 36-40 ◽

Cited By ~ 9

Author(s):

G. M. Patrickf ◽

J. F. Mahony ◽

A. P. S. Disney

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Renal Failure ◽

New Zealand ◽

Spina Bifida ◽

End Stage Renal Failure ◽

Cord Injury ◽

End Stage

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Fatal Renal Failure in a Spinal Cord Injury Patient with Vesicoureteric Reflux Who Underwent Repeated Ureteric Reimplantations Unsuccessfully: Treatment Should Focus on Abolition of High Intravesical Pressures rather than Surgical Correction of Reflux

Case Reports in Urology ◽

10.1155/2012/603715 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5

Author(s):

Subramanian Vaidyanathan ◽

Bakul Soni ◽

Kottarathil Abraham Abraham ◽

Peter Hughes ◽

Gurpreet Singh

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Renal Failure ◽

Vesicoureteral Reflux ◽

Vesicoureteric Reflux ◽

Intravenous Urography ◽

Spinal Cord Injury Patient ◽

Retrograde Filling ◽

Cord Injury ◽

Injury Patient

A 29-year-old man developed paraplegia at T-10 level due to road traffic accident in 1972. Both kidneys were normal and showed good function on intravenous urography. Division of external urethral sphincter was performed in 1973. In 1974, cystogram showed retrograde filling of left renal tract, which was hydronephrotic. Left ureteric reimplantation was performed. Following surgery, cystogram revealed marked retrograde filling of left renal tract as before. Penile sheath drainage was continued. In 1981, intravenous urography revealed bilateral severe hydronephrosis. Left ureteric reimplantation was performed again in 1983. Blood pressure was 220/140 mm Hg; this patient was prescribed atenolol. Cystogram showed gross left vesicoureteral reflux. Intermittent catheterisation was commenced in 2001. In 2007, proteinuria was 860 mg/day. This patient developed progressive renal failure and expired in 2012. In a spinal cord injury patient with vesicoureteral reflux, the treatment should focus on abolition of high intravesical pressures rather than surgical correction of vesicoureteric reflux. Detrusor hyperactivity and high intravesical pressures are the basic causes for vesicoureteral reflux in spinal cord injury patients. Therefore, it is important to manage spinal cord injury patients with neuropathic bladder by intermittent catheterisations along with antimuscarinic drug therapy in order to abolish high detrusor pressures and prevent vesicoureteral reflux. Angiotensin-converting enzyme inhibitors or angiotensin-receptor-blocking agents should be prescribed even in the absence of hypertension when a spinal cord injury patient develops vesicoureteral reflux and proteinuria.

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