Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs

Life Sciences ◽  
1998 ◽  
Vol 63 (4) ◽  
pp. 293-304 ◽  
Author(s):  
Ludmilla Mazelin ◽  
Vassilia Theodorou ◽  
Jean More ◽  
Xavier Emonds-Alt ◽  
Jean Fioramonti ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Receptor Antagonists ◽  
Gut Inflammation ◽  
Tachykinin Receptor

Effects of specific tachykinin receptor antagonists on citric acid-induced cough and bronchoconstriction in unanesthetized guinea pigs

1996 ◽  
Vol 300 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Ritsuko Yasumitsu ◽  
Yoshitaka Hirayama ◽  
Takumi Imai ◽  
Kikuo Miyayasu ◽  
Jun Hiroi
Keyword(s):  
Citric Acid ◽  
Guinea Pigs ◽  
Receptor Antagonists ◽  
Tachykinin Receptor

Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs

1993 ◽  
Vol 265 (5) ◽  
pp. L507-L511 ◽  
Author(s):  
C. Bertrand ◽  
P. Geppetti ◽  
P. D. Graf ◽  
A. Foresi ◽  
J. A. Nadel
Keyword(s):  
Guinea Pigs ◽  
Neurogenic Inflammation ◽  
Neutral Endopeptidase ◽  
Receptor Activation ◽  
Sensory Nerves ◽  
Pulmonary Resistance ◽  
Receptor Antagonists ◽  
Tachykinin Receptor ◽  
Nk2 Receptor

The role of tachykinins released from sensory nerves in bronchoconstriction induced by antigen was studied in sensitized guinea pigs anesthetized with pentobarbital sodium and pretreated with atropine. The combination of NK2 (SR-48968) and NK1 (CP-96,345) tachykinin-receptor antagonists abolished the increase in total pulmonary resistance (RL) evoked by intravenous capsaicin but did not affect the response evoked by intravenous histamine. A small dose of aerosolized ovalbumin (OVA, 0.1%) produced a small increase in RL that was further increased and markedly prolonged by the neutral endopeptidase (NEP) inhibitor phosphoramidon; this bronchoconstrictor effect of OVA was markedly reduced by the NK2-receptor antagonist and was abolished by the combination of the NK1 and NK2-receptor antagonists together. When a larger dose of OVA (0.5%) was used, a maximal bronchoconstrictor response was obtained. Phosphoramidon did not potentiate this response significantly. The combination of NK1- and NK2-receptor antagonists blunted the response at 5 min only slightly but markedly attenuated the later (10–20 min) response. These results show that tachykinins released from sensory nerves play a significant role in antigen-induced bronchoconstriction in guinea pigs. This effect is exaggerated when the normal modulation of neuropeptides by NEP is inhibited and is mediated predominantly by NK2-receptor activation, with a smaller contribution by NK1 receptors.

Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs

1992 ◽  
Vol 214 (2-3) ◽  
pp. 215-221 ◽  
Author(s):  
Lido Ballati ◽  
Stefano Evangelista ◽  
Carlo Alberto Maggi ◽  
Stefano Manzini
Keyword(s):  
Guinea Pigs ◽  
Receptor Antagonists ◽  
Tachykinin Receptor

Tachykinin receptor antagonists prevent senktide, castor oil, or E. coli endotoxin-induced increase of fecal mass output in guinea pigs

1998 ◽  
Vol 114 ◽  
pp. A361
Author(s):  
T. Croci ◽  
E. Ottolina ◽  
X. Emonds-Alt ◽  
L. Manara ◽  
G. Le Fur ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Castor Oil ◽  
Receptor Antagonists ◽  
E Coli ◽  
Tachykinin Receptor ◽  
Fecal Mass

scholarly journals The Role of Tachykinin Receptor Antagonists on Hyperpnea-induced Bronchoconstriction in Guinea Pigs

2008 ◽  
Vol 67 (6) ◽  
pp. 339-345
Author(s):  
Kaori Tsuda ◽  
Toru Majima ◽  
Reiko Ito ◽  
Tomohiro Hattori ◽  
Tsuneto Akashiba
Keyword(s):  
Guinea Pigs ◽  
Receptor Antagonists ◽  
Tachykinin Receptor

scholarly journals Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.

1993 ◽  
Vol 92 (1) ◽  
pp. 315-323 ◽  
Author(s):  
J Solway ◽  
B M Kao ◽  
J E Jordan ◽  
B Gitter ◽  
I W Rodger ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Receptor Antagonists ◽  
Tachykinin Receptor

Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat

1993 ◽  
Vol 232 (2-3) ◽  
pp. 255-261 ◽  
Author(s):  
Pierre Picard ◽  
Sylvie Boucher ◽  
Domenico Regoli ◽  
Bruce D. Gitter ◽  
Jeffrey J. Howbert ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Tachykinin Receptor ◽  
Nociceptive Reflex
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