Sustained attention deficit in bipolar disorder is not a working memory impairment in disguise

2002 ◽  
Vol 40 (9) ◽  
pp. 1586-1590 ◽  
Author(s):  
Catherine J Harmer ◽  
Luke Clark ◽  
Louise Grayson ◽  
Guy M Goodwin
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Sustained Attention ◽  
Attention Deficit ◽  
Memory Impairment

scholarly journals Working Memory Impairment in Euthymic State of Bipolar Disorder

2019 ◽  
Vol 8 (1) ◽  
pp. 50-54
Author(s):  
A Jha ◽  
D Joshi ◽  
P Kattel ◽  
P Koirala
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Memory Impairment ◽  
Digit Span ◽  
Case Group ◽  
Clinical Variables ◽  
Digit Span Test ◽  
Span Test ◽  
The Mean ◽  
Bipolar Patients

Introduction: Cognitive deficits in bipolar disorders persist after the subsidence of active symptoms. This study was carried out to assess the working memory of patients with bipolar disorder in euthymic state. Material And Method: Forty euthymic bipolar patients attending a tertiary care mental hospital with equal number of matched controls in terms of age, sex and education were included in the study. Working memory assessments was done using WAIS-III digit span subtest. Results: The mean of total digit span test for case group was 8.48±2.04 similarly it was 10.33±2.32 for the controls. The result showed that the mean digit span of cases and control groups are significantly different (p value of < 0.01). The Pearsons correlation between the clinical variables and working memory test in euthymic bipolar patients (case group) was found that the total score for digit span test was negatively correlated with all other clinical variables However, this correlation was found to be non-significant. Conclusion: The working memory impairment persists in remitted bipolar disorder patients and this may represent underlying trait abnormality not the state abnormality.

scholarly journals Relation between retinal vascular abnormalities and working memory impairment in patients with schizophrenia and bipolar disorder

2020 ◽  
Vol 49 ◽  
pp. 101942 ◽  
Author(s):  
Abhishek Appaji ◽  
Bhargavi Nagendra ◽  
Dona Maria Chako ◽  
Ananth Padmanabha ◽  
Arpitha Jacob ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Memory Impairment ◽  
Vascular Abnormalities

Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis

2006 ◽  
Vol 8 (2) ◽  
pp. 117-123 ◽  
Author(s):  
David C Glahn ◽  
Carrie E Bearden ◽  
Sibel Cakir ◽  
Jennifer A Barrett ◽  
Pablo Najt ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Memory Impairment ◽  
Lifetime History ◽  
History Of

scholarly journals Effects of methylphenidate on executive functioning in attention-deficit/hyperactivity disorder across the lifespan: a meta-regression analysis

2016 ◽  
Vol 46 (9) ◽  
pp. 1791-1807 ◽  
Author(s):  
H. G. H. Tamminga ◽  
L. Reneman ◽  
H. M. Huizenga ◽  
H. M. Geurts
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Working Memory ◽  
Sustained Attention ◽  
Response Inhibition ◽  
Attention Deficit ◽  
Animal Studies ◽  
Meta Analysis ◽  
Double Blind ◽  
Hyperactivity Disorder ◽  
Age Related

Attention-deficit/hyperactivity disorder (ADHD) in childhood and adulthood is often treated with the psychostimulant methylphenidate (MPH). However, it is unknown whether cognitive effects of MPH depend on age in individuals with ADHD, while animal studies have suggested age-related effects. In this meta-analysis, we first determined the effects of MPH on response inhibition, working memory and sustained attention, but our main goal was to examine whether these effects are moderated by age. A systematic literature search using PubMed, PsycINFO, Web of Science and MEDLINE for double-blind, placebo-controlled studies with MPH resulted in 25 studies on response inhibition (n = 775), 13 studies on working memory (n = 559) and 29 studies on sustained attention (n = 956) (mean age range 4.8–50.1 years). The effects of MPH on response inhibition [effect size (ES) = 0.40, p < 0.0001, 95% confidence interval (CI) 0.22–0.58], working memory (ES = 0.24, p = 0.053, 95% CI 0.00–0.48) and sustained attention (ES = 0.42, p < 0.0001, 95% CI 26–0.59) were small to moderate. No linear or quadratic age-dependencies were observed, indicating that effects of MPH on executive functions are independent of age in children and adults with ADHD. However, adolescent studies are lacking and needed to conclude a lack of an age-dependency across the lifespan.

scholarly journals Neuropsychological differences between attention deficit hyperactivity disorder and control children and adolescents referred for academic impairment

2009 ◽  
Vol 31 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Gabriel Coutinho ◽  
Paulo Mattos ◽  
Leandro F. Malloy-Diniz
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Working Memory ◽  
Children And Adolescents ◽  
Sustained Attention ◽  
Attention Deficit ◽  
Digit Span ◽  
Control Group ◽  
Memory Tests ◽  
Hyperactivity Disorder ◽  
Academic Impairment

OBJECTIVE: To compare the performances of children and adolescents with attention deficit hyperactivity disorder with a group of control comparison subjects, both taken from a large clinical sample, using some of the most widely employed attention-based Brazilian tests. METHOD: The performances of 186 children and adolescents with attention deficit hyperactivity disorder were compared to that of 80 control individuals based on attention and working memory scores. Both groups had been referred due to academic impairment. All individuals were submitted to the TAVIS-3 sustained, shifted and focused attention tests, as well as to the working memory tests that make up the WISC-III Freedom from Distractibility Index (Digit Span and Arithmetic). RESULTS: The control group was slightly older than the attention deficit hyperactivity disorder group (p = 0.07); IQ and schooling did not differ between groups (p = 0.34 and p = 0.38, respectively). While performing a test requiring sustained attention for a longer period of time, the attention deficit hyperactivity disorder group showed a significantly higher number of commission errors compared to the controls, thus presenting sustained attention deficits (p = 0.003); when the influence of IQ, age and schooling was reduced, the attention deficit hyperactivity disorder group also made more omission errors during a sustained attention task in comparison to the control group, thus achieving a borderline significance level (p = 0.08); the attention deficit hyperactivity disorder group also performed worse in Digit Span forward and backward (p = 0.013 and p = 0.01, respectively) and in Arithmetic (p = 0.008). Other scores did not achieve significance. CONCLUSION : Our findings suggest that some of the most commonly used Brazilian attention-based tests - especially the sustained attention and working memory tests - may be useful to help distinguish subjects with attention deficit hyperactivity disorder from control subjects.

Sustained attention deficit in bipolar disorder

2002 ◽  
Vol 180 (4) ◽  
pp. 313-319 ◽  
Author(s):  
Luke Clark ◽  
Susan D. Iversen ◽  
Guy M. Goodwin
Keyword(s):  
Bipolar Disorder ◽  
Sustained Attention ◽  
Attention Deficit ◽  
Verbal Memory ◽  
Neuropsychological Functioning ◽  
Attentional Set ◽  
Illness Onset ◽  
Affective Symptoms ◽  
Attentional Set Shifting ◽  
Neuropsychological Tasks

BackgroundRecovery in bipolar disorder is central to its definition but is rarely complete. Previous work has suggested that neuropsychological impairment persists during the euthymic state but has been confounded partly by mild affective symptoms in remitted patients.AimsTo characterise neuropsychological functioning in the euthymic phase of bipolar disorder with an emphasis on tasks of executive functioning.MethodThirty euthymic patients with bipolar disorder were compared with thirty healthy controls on neuropsychological tasks differentially sensitive to damage within prefrontal cortex.ResultsBipolar I patients were impaired on tasks of attentional set shifting, verbal memory and sustained attention. Only sustained attention deficit survived controlling for mild affective symptoms. This deficit was related to progression of illness, but was none the less present in a subgroup of patients near illness onset.ConclusionsSustained attention deficit may represent a neuropsychological vulnerability marker for bipolar disorder, providing a focus for further understanding of the phenotype and analysis of the neuronal networks involved.

4.26 Sustained Attention Deficit in Unaffected Offspring of Parents With Bipolar Disorder

2018 ◽  
Vol 57 (10) ◽  
pp. S213
Author(s):  
Ramandeep S. Kahlon ◽  
Christopher D. Verrico ◽  
Ruchir P. Arvind ◽  
Ajay Shah ◽  
Cristian P. Zeni ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Sustained Attention ◽  
Attention Deficit
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