Xenotransplantation of isolated encapsulated porcine hepatocytes in the treatment of a highly fulminant hepatic failure Model

1997 ◽  
Vol 29 (1-2) ◽  
pp. 920-922 ◽  
Author(s):  
P.A. Rivas-Vetencourt ◽  
E.D. Aranda ◽  
L. Sorio ◽  
Z. Quero ◽  
A. Martinez ◽  
...  
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Failure Model ◽  
Porcine Hepatocytes

Facilitation of Survival in a Rat Fulminant Hepatic Failure Model by Combination Therapy Using Recombinant G-CSF and Tacrolimus

2006 ◽  
Vol 26 (4) ◽  
pp. 226-234 ◽  
Author(s):  
Xuehelati Aihaiti ◽  
Keisuke Hayamizu ◽  
Koichi Oishi ◽  
Masanori Yoshimitsu ◽  
Toshiyuki Itamoto ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Failure Model

scholarly journals High Metabolic Function of Primary Human and Porcine Hepatocytes in a Polyurethane Foam/Spheroid Culture System in Plasma from Patients with Fulminant Hepatic Failure

2002 ◽  
Vol 11 (4) ◽  
pp. 379-384 ◽  
Author(s):  
Yo-Ichi Yamashita ◽  
Mitsuo Shimada ◽  
Eiji Tsujita ◽  
Ken Shirabe ◽  
Hiroyuki Ijima ◽  
...  
Keyword(s):  
Polyurethane Foam ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Culture System ◽  
Monolayer Culture ◽  
Ammonia Content ◽  
Spheroid Culture ◽  
Metabolic Functions ◽  
Fisher’S Ratio ◽  
Porcine Hepatocytes

It has been demonstrated that plasma from patients with fulminant hepatic failure (FHF) interferes extensively with cellular function. We placed primary human and primary porcine hepatocytes in a polyurethane foam (PUF)/spheroid culture system and compared the metabolic functions in the plasma of patients with FHF in a 24-h stationary culture to those in a monolayer culture. The PUF/spheroid culture system using primary human and primary porcine hepatocytes significantly decreased ammonia content during 28-day culture. Fisher's ratio significantly increased at culture days 3 and 7. Tauroursodeoxycholic acid significantly increased and glycochenodeoxycholic acid and taurochenodeoxycholic acid decreased in the FHF patients' plasma at culture day 3. During at least a 24-h culture in the FHF patients' plasma, metabolic functions of primary human and primary porcine hepatocytes were almost identical. The present results indicate that the PUF/spheroid culture system using primary human or primary porcine hepatocytes demonstrated more advantageous metabolic functions in the plasma from patients with FHF than the monolayer culture.

793 An Increased Serum Level of High-Mobility Group Box 1 in the Pig Fulminant Hepatic Failure Model

2008 ◽  
Vol 134 (4) ◽  
pp. A-772
Author(s):  
Kiminori Takano ◽  
Masahiro Shinoda ◽  
Minoru Tanabe ◽  
Yasushi Fuchimoto ◽  
Taku Miyasho ◽  
...  
Keyword(s):  
Serum Level ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Failure Model

PRECLINICAL TRIAL OF A BlOARTlFlClAL LIVER SUPPORT SYSTEM IN A PORCINE FULMINANT HEPATIC FAILURE MODEL

1996 ◽  
Vol 66 (8) ◽  
pp. 547-552 ◽  
Author(s):  
A. G. R. Sheil ◽  
J. Sun ◽  
D. C. Mears ◽  
M. Warin ◽  
K. Woodman ◽  
...  
Keyword(s):  
Support System ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Failure Model ◽  
Liver Support ◽  
Preclinical Trial ◽  
Liver Support System
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