Elimination of the adverse effects of tacrolimus-based induction therapy by a 5-day exposure of optimal steady-state blood concentration in renal transplant patients in the early postoperative period

1999 ◽  
Vol 31 (7) ◽  
pp. 2761-2762 ◽  
Author(s):  
M Ishibashi ◽  
S Miyamoto ◽  
M Nojima ◽  
T Yoshimoto ◽  
H Yabumoto ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Adverse Effects ◽  
Induction Therapy ◽  
Postoperative Period ◽  
Blood Concentration ◽  
Early Postoperative Period ◽  
Transplant Patients ◽  
Renal Transplant Patients

scholarly journals MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients

2004 ◽  
Vol 58 (5) ◽  
pp. 548-553 ◽  
Author(s):  
Ingrid Mai ◽  
Elke S. Perloff ◽  
Steffen Bauer ◽  
Mark Goldammer ◽  
Andreas Johne ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Transplant Patients ◽  
Renal Transplant Patients

Determination of cyclosporine concentrations with monoclonal antibodies.

1987 ◽  
Vol 33 (12) ◽  
pp. 2225-2229 ◽  
Author(s):  
H F Schran ◽  
T G Rosano ◽  
A E Hassell ◽  
M A Pell
Keyword(s):  
Single Dose ◽  
Steady State ◽  
Renal Transplant ◽  
Cross Reactivity ◽  
Transplant Patients ◽  
Concentration Time ◽  
Dose Concentration ◽  
Renal Transplant Patients ◽  
Oral Doses

Abstract We measured cyclosporine in whole blood from normal volunteers administered single oral doses of the drug and from two renal-transplant patients on immunosuppressive maintenance therapy, by liquid chromatography (I) and by radioimmunoassay with use of nonspecific polyclonal (II), specific monoclonal (III), and nonspecific monoclonal (IV) antibodies. Concentrations determined by III were equivalent to I, irrespective of cyclosporine dose, concentration, time after dose, or time after transplant. Concentrations determined by II and IV were consistently higher than those by I, owing to cross reactivity with metabolites. Ratios of values by II and IV to those by I increased from less than 1.5 to about 3-4 between 0.5 and 12 h after a single cyclosporine dose, owing to differences in rates of appearance and disappearance of cyclosporine and cross-reacting metabolites, though for the constant 12-h dose intervals in the two renal-transplant patients at steady state these ratios (most within the range 3-4) were relatively stable. Ratios of concentrations measured by IV to those by II (mean of 1.2 for single-dose data, most within the range of 1.2 to 1.5 at steady state) were unaffected by time after dose or time after transplant, suggesting that, despite certain cross-reactivity differences between the two nonspecific antibodies, results are proportional throughout therapy. We therefore propose that III and IV offer alternatives, respectively, to the currently used I and II for cyclosporine monitoring.

Steady-state pharmacokinetics of sirolimus in stable adult Chinese renal transplant patients

2014 ◽  
Vol 3 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Huifen Faye Wang ◽  
Feng Qiu ◽  
Xiongfe Wu ◽  
Juanzhi Fang ◽  
Penelope Crownover ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Transplant Patients ◽  
Renal Transplant Patients

STEADY-STATE PHARMACOKINETICS AND TOLERABILITY OF RAD AND ITS INFLUENCE ON CYCLOSPORINE IN STABLE RENAL TRANSPLANT PATIENTS

1999 ◽  
Vol 67 (7) ◽  
pp. S160 ◽  
Author(s):  
J Dantal ◽  
G Lehne ◽  
M Winkler ◽  
I A Hauser ◽  
A E Lison ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Transplant Patients ◽  
Renal Transplant Patients

Evaluation of the effect of candesartan cilexetil on the steady-state pharmacokinetics of tacrolimus in renal transplant patients

2005 ◽  
Vol 26 (4) ◽  
pp. 135-141 ◽  
Author(s):  
Frank Pietruck ◽  
Gerhard Kiel ◽  
Manfred Birkel ◽  
Bodo Stahlheber-Dilg ◽  
Thomas Philipp
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Candesartan Cilexetil ◽  
Transplant Patients ◽  
Renal Transplant Patients

EXPERIENCE WITH TWO-DOSE DACLIZUMAB INDUCTION THERAPY IN PEDIATRIC RENAL TRANSPLANT PATIENTS

2010 ◽  
Vol 90 ◽  
pp. 1053
Author(s):  
S. Sevmis ◽  
A. Akdur ◽  
S. Aktas ◽  
E. Baskin ◽  
H. Karakayali ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Induction Therapy ◽  
Transplant Patients ◽  
Pediatric Renal Transplant ◽  
Renal Transplant Patients

Influence of Everolimus on Steady-State Pharmacokinetics of Cyclosporine in Maintenance Renal Transplant Patients

2005 ◽  
Vol 45 (7) ◽  
pp. 781-791 ◽  
Author(s):  
Klemens Budde ◽  
Gustav Lehne ◽  
Michael Winkler ◽  
Lutz Renders ◽  
Arno Lison ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Transplant Patients ◽  
Renal Transplant Patients
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