Investigation of lipase-catalysed hydrolysis of naproxen methyl ester: use of NMR spectroscopy methods to study substrate–enzyme interaction

2002 ◽  
Vol 30 (4) ◽  
pp. 276-284 ◽  
Author(s):  
E Cernia ◽  
M Delfini ◽  
E Di Cocco ◽  
C Palocci ◽  
S Soro
Keyword(s):  
Nmr Spectroscopy ◽  
Methyl Ester ◽  
Hydrolysis Of ◽  
Naproxen Methyl Ester

scholarly journals Preparation and Synthetic Application of Naproxen-Containing Diaryliodonium Salts

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3240
Author(s):  
Jun Zhou ◽  
Zhiyuan Bao ◽  
Panpan Wu ◽  
Chao Chen
Keyword(s):  
Methyl Ester ◽  
Aromatic Ring ◽  
Solvent Mixture ◽  
Iodonium Salts ◽  
Diaryliodonium Salts ◽  
Esterification Reactions ◽  
Trimethylsilyl Trifluoromethanesulfonate ◽  
Synthetic Application ◽  
Hydrolysis Of ◽  
Naproxen Methyl Ester

The synthesis of naproxen-containing diaryliodonium salts has been realized from naproxen methyl ester and ArI(OH)OTs activated by trimethylsilyl trifluoromethanesulfonate (TMSOTf) in a solvent mixture comprising dichloromethane and 2,2,2-trifluoroethanol (TFE). Those iodonium salts have been successfully used in the functionalization of an aromatic ring of naproxen methyl ester, including fluorination, iodination, alkynylation, arylation, thiophenolation, and amination and esterification reactions. Moreover, further hydrolysis of the obtained 5-iodo-naproxen methyl ester afforded 5-iodo-naproxen.

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