Plasma Level of Triglyceride-rich Lipoprotein Remnants Is Closely Associated with the Activation of Coagulation Factor VII in Patients with Myocardial Infarction

2000 ◽  
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1998 ◽  
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1998 ◽  
Vol 79 (05) ◽  
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Johan Holm ◽  
Tim Tödt ◽  
Erik Berntorp ◽  
Leif Erhardt

SummaryThrombolytic therapy in acute myocardial infarction fails to re-establish coronary blood flow in a significant number of patients. One reason for this may be haemostatic imbalance. We investigated whether coagulation factor VII antigen (FVIIag), fibrinogen and protein C were related to reperfusion. Plasma from 45 patients was drawn before treatment and reperfusion assessed by means of continuous, on-line, vector-ECG analysis.Amongthe 17 patients with no reperfusion, FVIIag levels were significantly higher than among the 28 with signs of reperfusion (560 vs. 410 μg/l median, p = 0.006). Protein C levels where higher in the group with successful reperfusion (1.10 vs. 1.01 U/ml median, p = 0.03), whereas no difference was seen in fibrinogen levels. The findings were not influenced by plasma-triglycerides, body-mass index, age or time between onset of chest pain and thrombolytic therapy.The results suggest that FVII is of importance for the formation as well as resolution of coronary clots.


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