Chapter 12 Molecular Characteristics of Sodium Channels in Skeletal Muscle

1988 ◽  
pp. 251-270 ◽  
Author(s):  
Robert L. Barchi
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Molecular Characteristics

scholarly journals Design of a Specific Activator for Skeletal Muscle Sodium Channels Uncovers Channel Architecture

2007 ◽  
Vol 282 (40) ◽  
pp. 29424-29430 ◽  
Author(s):  
Lior Cohen ◽  
Nitza Ilan ◽  
Maya Gur ◽  
Walter Stühmer ◽  
Dalia Gordon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Channel Architecture

Tetrodotoxin-insensitive sodium channels in a cardiac cell line from a transgenic mouse

1992 ◽  
Vol 262 (3) ◽  
pp. C724-C730 ◽  
Author(s):  
A. Sculptoreanu ◽  
M. Morton ◽  
C. L. Gartside ◽  
S. D. Hauschka ◽  
W. A. Catterall ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Line ◽  
Transgenic Mouse ◽  
Sodium Channels ◽  
Sodium Current ◽  
Cardiac Cell ◽  
Dependent Protein Kinase ◽  
Electrophysiological Properties ◽  
Maximal Activation ◽  
Dependent Protein

The electrophysiological properties of a cardiac cell line (MCM1) originating from a transgenic mouse were characterized. The dominant current in these cells is a sodium current that is insensitive to concentrations of tetrodotoxin (TTX) up to 100 microM. It activates and inactivates rapidly with half-maximal activation at -40 mV and half-maximal inactivation at -79 mV. This sodium current is reduced by agents that increase intracellular adenosine 3',5'-cyclic monophosphate (cAMP) and activate cAMP-dependent protein kinase including isoproterenol, 8-bromo-cAMP, and isobutylmethylxanthine. The phenylalkylamine desmethoxyverapamil blocks the TTX-insensitive sodium current in MCM1 cells in both tonic and use-dependent fashion. Membrane depolarization enhances this block. It is proposed that the TTX-insensitive sodium current in these cells may be similar in origin to the embryonic type of TTX-insensitive sodium current described in other cardiac and skeletal muscle preparations.

scholarly journals Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels

1996 ◽  
Vol 70 (1) ◽  
pp. 238-245 ◽  
Author(s):  
D.W. Wang ◽  
A.L. George ◽  
P.B. Bennett
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels

Molecular characteristics of amiloride-sensitive sodium channels

1992 ◽  
pp. 31-113 ◽  
Author(s):  
Dale J. Benos ◽  
Sonia Cunningham ◽  
R. Randall Baker ◽  
K. Beth Beason ◽  
Youngsuk Oh ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Molecular Characteristics
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