Structural and Functional Analysis of Chondroitin Sulfate Proteoglycans in the Neural Stem Cell Niche

Author(s):  
Swetlana Sirko ◽  
Kaoru Akita ◽  
Alexander Von Holst ◽  
Andreas Faissner
2017 ◽  
Vol 21 (3) ◽  
pp. 293-294 ◽  
Author(s):  
Julia P. Andreotti ◽  
Luiza Lousado ◽  
Luiz Alexandre V. Magno ◽  
Alexander Birbrair

2011 ◽  
Vol 71 (11) ◽  
pp. 1006-1017 ◽  
Author(s):  
Ilias Kazanis ◽  
Charles ffrench-Constant

Stem Cells ◽  
2020 ◽  
Author(s):  
Grit Weselek ◽  
Silke Keiner ◽  
Mareike Fauser ◽  
Lisa Wagenführ ◽  
Julia Müller ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Mahesh Kandasamy ◽  
Ralf Reilmann ◽  
Jürgen Winkler ◽  
Ulrich Bogdahn ◽  
Ludwig Aigner

The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.


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