Session 4 DNA glycosylases: Specificity and mechanisms

2001 ◽  
pp. 189-192 ◽  
Author(s):  
Sankar Mitra
Keyword(s):  
Dna Glycosylases

scholarly journals Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter

2021 ◽  
Vol 22 (3) ◽  
pp. 1137
Author(s):  
Annalisa Ferino ◽  
Luigi E. Xodo
Keyword(s):  
Oxidative Stress ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Start Site ◽  
Dna Glycosylases ◽  
Repair Pathway ◽  
Transcription Start ◽  
G Quadruplex ◽  
Base Excision ◽  
Regulatory Functions

The promoter of the Kirsten ras (KRAS) proto-oncogene contains, upstream of the transcription start site, a quadruplex-forming motif called 32R with regulatory functions. As guanine under oxidative stress can be oxidized to 8-oxoguanine (8OG), we investigated the capacity of glycosylases 8-oxoguanine glycosylase (OGG1) and endonuclease VIII-like 1 (Neil1) to excise 8OG from 32R, either in duplex or G-quadruplex (G4) conformation. We found that OGG1 efficiently excised 8OG from oxidized 32R in duplex but not in G4 conformation. By contrast, glycosylase Neil1 showed more activity on the G4 than the duplex conformation. We also found that the excising activity of Neil1 on folded 32R depended on G4 topology. Our data suggest that Neil1, besides being involved in base excision repair pathway (BER), could play a role on KRAS transcription.

DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus

DNA Repair ◽  
2021 ◽  
pp. 103160
Author(s):  
Anton V. Endutkin ◽  
Elena P. Panferova ◽  
Alexander E. Barmatov ◽  
Dmitry O. Zharkov
Keyword(s):  
Staphylococcus Aureus ◽  
Dna Glycosylases

scholarly journals Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria

2006 ◽  
Vol 41 (5) ◽  
pp. 757-764 ◽  
Author(s):  
Svetlana N. Radyuk ◽  
Katarzyna Michalak ◽  
Igor Rebrin ◽  
Rajindar S. Sohal ◽  
William C. Orr
Keyword(s):  
Ectopic Expression ◽  
Dna Glycosylases

scholarly journals Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2

2007 ◽  
Vol 35 (11) ◽  
pp. 3859-3867 ◽  
Author(s):  
Ulrike Hardeland ◽  
Christophe Kunz ◽  
Frauke Focke ◽  
Marta Szadkowski ◽  
Primo Schär
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Dna Glycosylases ◽  
Cycle Regulation

The effect of sequence context on the activity of cytosine DNA glycosylases

2015 ◽  
Vol 11 (12) ◽  
pp. 3273-3278
Author(s):  
Scott T. Kimber ◽  
Tom Brown ◽  
Keith R. Fox
Keyword(s):  
Dna Glycosylase ◽  
Dna Glycosylases ◽  
Sequence Context ◽  
Uracil Dna Glycosylase

We have examined how sequence context affects the ability of (N204D:L272A) mutants of uracil DNA glycosylase to cleave CX mismatches.

scholarly journals 8-Oxoguanine DNA Glycosylases: One Lesion, Three Subfamilies

2012 ◽  
Vol 13 (6) ◽  
pp. 6711-6729 ◽  
Author(s):  
Frédérick Faucher ◽  
Sylvie Doublié ◽  
Zongchao Jia
Keyword(s):  
Dna Glycosylases

Conformational dynamics and pre-steady-state kinetics of DNA glycosylases

2010 ◽  
Vol 75 (10) ◽  
pp. 1225-1239 ◽  
Author(s):  
O. S. Fedorova ◽  
N. A. Kuznetsov ◽  
V. V. Koval ◽  
D. G. Knorre
Keyword(s):  
Steady State ◽  
Conformational Dynamics ◽  
Dna Glycosylases ◽  
Steady State Kinetics ◽  
Kinetics Of

scholarly journals Repair of oxidative cytosine damage by DNA glycosylases

2003 ◽  
Vol 3 (1) ◽  
pp. 269-270 ◽  
Author(s):  
A. Katafuchi ◽  
A. Matsuo ◽  
H. Terato ◽  
Y. Ohyama ◽  
H. Ide
Keyword(s):  
Dna Glycosylases

scholarly journals 5-Methylcytosine Recognition by Arabidopsis thaliana DNA Glycosylases DEMETER and DML3

Biochemistry ◽  
2014 ◽  
Vol 53 (15) ◽  
pp. 2525-2532 ◽  
Author(s):  
Sonja C. Brooks ◽  
Robert L. Fischer ◽  
Jin Hoe Huh ◽  
Brandt F. Eichman
Keyword(s):  
Arabidopsis Thaliana ◽  
Dna Glycosylases
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