Contrast-enhanced cardiovascular magnetic resonance plays a pivotal role in diagnostic and prognostic definition of less common pathologies such as Anderson–Fabry disease, cardiac amyloidosis, left ventricular non-compaction, sarcoidosis, and cardiac iron loading. In recent years, new cardiovascular magnetic resonance techniques, such as T1 and T2 mapping, have provided powerful tools for the study of these pathologies, especially those with a hypertrophic phenotype.