Presence of mature sperm in testicular parenchyma of men with nonobstructive azoospermia: Prevalence and predictive factors

Azoospermia is the absence of spermatozoa in ejaculate even after semen centrifugation at least two times. Azoospermia due to spermatogenic failure – non-obstructive azoospermia (NOA) observed in 1% of population and in 10–15% of infertile men. Predictive factors for the presence of spermatozoa in testis are still under debate. The development of ICSI revolutionized management of azoospermia. In our practice we advised TESA as a first step and FSH can predict the success. According serum FSH levels we divided our men in three groups: FSH < 10 mU/ml, 10–15 mU/ml and > 15 mU/ml. We tried to evaluated SRR in accordance serum FSH level and find significant difference. In 117 men with FSH < 10 mU/ml SRR was 66% (in 77 cases), in 89 men which FSH was 10–15 mU/ml SRR was 27 % and finally SRR was 35% when FSH was > 15 mU/ml (45 cases from 131). At the same time, we make embryologist personal assessment (EPA) and try to show embryologist crucial role in tissue assessment after TESA. Another crucial point of discussion – histomorphology within the testis in NOA and indications for re – TESA after 3–6 months.

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Circulatory exosomal tRF-Glu-CTC-005 and tRF-Gly-GCC-002 serve as predictive factors of successful microdissection testicular sperm extraction in patients with nonobstructive azoospermia

Fertility and Sterility ◽

10.1016/j.fertnstert.2021.11.010 ◽

2021 ◽

Author(s):

Qiang Zhang ◽

Zhao Liu ◽

Xiaoxiao Han ◽

Ying Li ◽

Tian Xia ◽

...

Keyword(s):

Predictive Factors ◽

Testicular Sperm Extraction ◽

Nonobstructive Azoospermia ◽

Testicular Sperm

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Male Infertility and Its Causes in Human

Advances in Urology ◽

10.1155/2012/384520 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 26

Author(s):

Toshinobu Miyamoto ◽

Akira Tsujimura ◽

Yasushi Miyagawa ◽

Eitetsu Koh ◽

Mikio Namiki ◽

...

Keyword(s):

Environmental Factors ◽

Male Infertility ◽

Effective Treatment ◽

Genetic Predisposition ◽

Social Problems ◽

Male Partner ◽

Mature Sperm ◽

Nonobstructive Azoospermia

Infertility is one of the most serious social problems facing advanced nations. In general, approximate half of all cases of infertility are caused by factors related to the male partner. To date, various treatments have been developed for male infertility and are steadily producing results. However, there is no effective treatment for patients with nonobstructive azoospermia, in which there is an absence of mature sperm in the testes. Although evidence suggests that many patients with male infertility have a genetic predisposition to the condition, the cause has not been elucidated in the vast majority of cases. This paper discusses the environmental factors considered likely to be involved in male infertility and the genes that have been clearly shown to be involved in male infertility in humans, including our recent findings.

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Re: Predictive Factors for Sperm Recovery After Varicocelectomy in Men with Nonobstructive Azoospermia

Journal of Urological Surgery ◽

10.4274/jus.2017.04.005 ◽

2017 ◽

Vol 4 (1) ◽

pp. 39-39

Author(s):

Emre Bakırcıoğlu

Keyword(s):

Predictive Factors ◽

Nonobstructive Azoospermia ◽

Sperm Recovery

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Spermatogenesis in the Dragonfly with Particular Reference to the Cytoplasmic Organelles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100093808 ◽

1972 ◽

Vol 30 ◽

pp. 110-111

Author(s):

Sant S. Sekhon

Keyword(s):

Endoplasmic Reticulum ◽

Golgi Apparatus ◽

Mature Sperm ◽

Electron Microscopic ◽

Cytoplasmic Organelles ◽

Microscopic Studies ◽

Insect Sperm ◽

Large Round

Although there have been numerous studies concerning the morphogenetic changes accompanying the maturation of insect sperm, only a few deal with the sperm differentiation in the dragonflies. In two recent electron microscopic studies Kessel, has comprehensively treated the erlationship of microtubules to the nucleus and mid-piece structures during spermiogenesis in the dragonfly. The purpose of this study is to follow the sequential nuclear and cytoplasmic changes which accompany the differentiation of spermatogonium into a mature sperm during spermatogenesis in the dragonfly (Aeschna sp.).The dragonfly spermatogonia are characterized by large round nuclei. Loosely organized chromatin is usually unevenly distributed within the spermatogonial nuclei. The scant cytoplasm surrounding the nucleus contains mitochondria, the Golgi apparatus, elements of endoplasmic reticulum and numerous ribosomes (Fig. 1).

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