male partner
Recently Published Documents


TOTAL DOCUMENTS

718
(FIVE YEARS 287)

H-INDEX

41
(FIVE YEARS 5)

2022 ◽  
Author(s):  
Umesh Kumar ◽  
Digumarthi V S Sudhakar ◽  
Nithyapriya Kumar ◽  
Hanuman T Kale ◽  
Rajan Kumar Jha ◽  
...  

AbstractThe recent epidemiological studies suggest that nearly one out of every 7 reproductive age couples face problem to conceive a child after trying for at least one year. Impaired fertility of the male partner is causative in approximately 50% of the infertile couples. However, the etiologies of large proportion of male infertility are still unclear. Our unpublished exome sequencing data identified several novel genes including TEX13B, which motivated us to further explore the role of TEX13B in male infertility in large infertile case control cohort. Hence in this study, we have examined the role of TEX13B in male infertility by whole gene sequencing 628 infertile and 427 control men and have demonstrated the functional role of Tex13b in spermatogonia GC1spg (GC1) cells. We identified 2 variants on TEX13B which are tightly associated with male infertility. TEX13B gene exclusively expressed in germ cells, but its molecular functions in germ cells are still unknown. Hence, we demonstrated the functional importance of Tex13b in GC1 cell line by genomic manipulation via CRISPR-Cas9 and mass spectrometry-based whole cell proteomics. The gene knock out in GC1 cell line clearly shows that Tex13b play an important role in germ cell growth and morphology. We demonstrate that Tex13b knockout or conditional overexpression in GC1 cells reprograms the metabolic status from an oxidative phosphorylation to glycolysis state and vice versa. In conclusion, our study clearly showed the importance of Tex13b in germ cells development and Its association with male infertility.


2021 ◽  
Vol 29 (01) ◽  
pp. 53-56
Author(s):  
Asim Iqbal Qureshi ◽  
Tehreem Rasheed ◽  
Ayesha Munir ◽  
Taqwa Firdous ◽  
Maria Khan ◽  
...  

Objective: To evaluate the frequency of semen parameters in male partners of in sub-fertile couples. Study Design: Cross-sectional study. Setting: Department of Gynaecology, Bakhtawar Ameen Hospital, Multan. Period: July 2019 to July 2020. Material & Methods: Infertile couples from at least 12 months were selected for study. A team of Gynaecologist, andrologist and endocrinologist assessed the couples. In male partner, general physical examination, endocrine factor, genetic assessment, accessory gland infection and testicular dysfunction were evaluated. Semen sample was sent to laboratory for semen analysis. Results: In a total of 169 sub-fertile couples, the mean age of male and female partner were 37.98±4.54 years and 32.51±3.78 years respectively. Mean duration since marriage was 5.17±4.51 years. Abnormal semen parameters such as azoospermia, oilgo-azoospermia, asthenozoospermia, teratozoospermia and aspermia were noted 21 (12.4%), 26 (15.4%), 48 (28.4%), 18 (10.7%) and 10 (5.9%) subjects respectively. There were 46 (27.2%) subjects with normal semen parameters. Conclusion: Most of the male sub-fertile subjects had asthenozoospermia. More than one fourth of the subjects had normal semen parameters.


2021 ◽  
Vol 2 ◽  
Author(s):  
Thérèse Delvaux ◽  
Vicky Jespers ◽  
Lenka Benova ◽  
Janneke van de Wijgert

Introduction: Acceptability of and satisfaction with contraceptive methods are paramount for uptake and continuation. In the current context of multipurpose prevention of pregnancy and sexually transmitted diseases/HIV development, it is critical to have a better understanding of acceptability of and satisfaction with the contraceptive vaginal ring (CVR) including sexual satisfaction. The objective of this study was to review the evidence about acceptability of CVRs and general and sexual satisfaction of users.Methods: We searched PubMed, CINAHL, and Web of Science (until December 31, 2020) and selected original studies documenting actual use of hormonal CVR and explicitly addressing any of the 3 outcomes.Results: Of a total of 1,129 records screened, 46 studies were included. Most studies (n = 43, 93%) were prospective, conducted in high-income settings (n = 35), and reported on NuvaRing® use (n = 31). Overall, 27 (59%) studies included a comparison group, 38 (82%) studies used exclusively quantitative questionnaires, with qualitative only (n = 4, 9%), or mixed methods (n = 4, 9%) studies being less common. Ease of CVR insertion/removal/reinsertion was high in all the settings and improved with time of use, with qualitative studies supporting these findings. When mentioned, ring-related events were associated with discontinuation, and results on continuation of use were mixed. Among NuvaRing® studies, general satisfaction (being satisfied or very satisfied) was between 80 and 90% and tended to mirror continuation. Sexual satisfaction was less commonly reported and results were mixed. Overall, limited information was provided on actual CVR experiences of women (and men) and cultural norms that may affect sexuality and CVR use.Conclusion: Positive aspects of acceptability of and satisfaction with CVRs were reported, but ring-related events and factors, which may affect long-term CVR use, deserve further study. More information is needed on actual experiences of women using CVRs, relationship aspects, male partner opinions, and contextual norms to better understand the acceptability of and satisfaction with CVRs.


PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0259980
Author(s):  
Blessing Akombi-Inyang ◽  
Pramesh Raj Ghimire ◽  
Elizabeth Archibong ◽  
Emma Woolley ◽  
Husna Razee

The utilization of perinatal care services among women experiencing intimate partner violence (IPV) and male alcohol use is a major problem. Adequate and regular perinatal care is essential through the continuum of pregnancy to mitigate pregnancy and birth complications. The aim of this study is to determine the association between IPV and male alcohol use and the receipt of perinatal care in Nepal. This study used pooled data from 2011 and 2016 Nepal Demographic and Health Surveys (NDHS). A total of 3067 women who interviewed for domestic violence module and had most recent live birth 5 years prior surveys were included in the analysis. Multivariable logistic regression analysis was performed to determine the association between IPV and male alcohol use and the receipt of perinatal care. Of the total women interviewed, 22% reported physical violence, 14% emotional violence, and 11% sexual violence. Women who were exposed to physical violence were significantly more likely to report non-usage of institutional delivery [adjusted Odds Ratio (aOR) = 1.30 (95% Cl: 1.01, 1.68)] and skilled delivery assistants [aOR = 1.43 (95% Cl: 1.10, 1.88)]. Non-attendance of 4 or more skilled antenatal care visits was associated with a combination of alcohol use by male partner and exposure to emotional [aOR = 1.42 (95% Cl: 1.01, 2.00)] and physical violence [aOR = 1.39 (95% Cl: 1.03, 1.88)]. The negative association between IPV and perinatal care suggests it is essential to develop comprehensive community-based interventions which integrates IPV support services with other health services to increase the uptake of perinatal care through the continuum of pregnancy.


PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260694
Author(s):  
Michele Montandon ◽  
Timothy Efuntoye ◽  
Ijeoma U. Itanyi ◽  
Chima A. Onoka ◽  
Chukwudi Onwuchekwa ◽  
...  

Background Nigeria has low antiretroviral therapy (ART) coverage among HIV-positive pregnant women. In a previous cluster-randomized trial in Nigeria, Baby Shower events resulted in higher HIV testing coverage and linkage of pregnant women to ART; here, we assess outcomes of Baby Shower events in a non-research setting. Methods Baby Shower events, including a prayer ceremony, group education, music, gifting of a “mama pack” with safe delivery supplies, and HIV testing with ART linkage support for HIV-positive pregnant women, were conducted in eighty sites in Benue State, Nigeria. Client questionnaires (including demographics, ANC attendance, and HIV testing history), HIV test results, and reported linkage to ART were analyzed. Descriptive data on HIV testing and ART linkage data for facility-based care at ANC clinics in Benue State were also analyzed for comparison. Results Between July 2016 and October 2017, 10,056 pregnant women and 6,187 male partners participated in Baby Shower events; 61.5% of women attended with a male partner. Nearly half of female participants (n = 4515, 44.9%) were not enrolled in ANC for the current pregnancy, and 22.3% (n = 2,241) of female and 24.8% (n = 1,532) of male participants reported they had never been tested for HIV. Over 99% (n = 16,240) of participants had their HIV status ascertained, with 7.2% of females (n = 724) and 4.0% of males (n = 249) testing HIV-positive, and 2.9% of females (n = 274) and 2.3% of males (n = 138) receiving new HIV-positive diagnoses. The majority of HIV-positive pregnant women (93.0%, 673/724) were linked to ART. By comparison, at health facilities in Benue State during a similar time period, 99.7% of pregnant women had HIV status ascertained, 8.4% had a HIV-positive status, 2.1% were newly diagnosed HIV-positive, and 100% were linked to ART. Conclusion Community-based programs such as the faith-based Baby Shower intervention complement facility-based approaches and can reach individuals who would not otherwise access facility-based care. Future Baby Showers implementation should incorporate enhanced support for ART linkage and retention to maximize the impact of this intervention on vertical HIV transmission.


2021 ◽  
Vol 8 (12) ◽  
pp. e736-e746
Author(s):  
Harsha Thirumurthy ◽  
Elizabeth F Bair ◽  
Perez Ochwal ◽  
Noora Marcus ◽  
Mary Putt ◽  
...  

2021 ◽  
Author(s):  
Kabalkin B. Yossef ◽  
Yaakov Bentov ◽  
Moran Gil ◽  
Ofer Beharier ◽  
Sireen Jaber ◽  
...  

Abstract Background: COVID-19 global pandemic has affected more than 250 million people so far. Data regarding potential effects on reproduction are still limited. Our aim was to examine the effect of COVID-19 on post exposure IVF cycle parameters and obstetric outcomes of IVF-achieved pregnancies.The study contained two arms: a retrospective arm comparing IVF outcome parameters among patients exposed to COVID-19 having an IVF cycle within 3 months of exposure. Post COVID-19 cycle parameters were compared to previous cycles of the same individual, performed within one year of exposure. If not available, parameters were compared to non-exposed matched patients. Sperm parameters were compared before and after exposure. The second arm was prospective comparing pregnancy outcomes among IVF patients who contracted COVID-19 during pregnancy, vs. those who did not. Results: The first arm included 120 cycle of which 60 were in exposed female patients and another 60 in either the same patients prior to exposure or matched non exposed patients. Generally, total FSH dose, cycle length, and ovarian response did not significantly differ across exposure groups: including peak serum estradiol, number of oocytes and endometrial thickness, fertilization rate and number of top-quality embryos, were similar between exposed and non-exposed cycles. In 11 of the cycles in which the female partner was exposed the male partner had been recently exposed as well. In these couples, sperm quality showed a significantly lower post-exposure concentration: 6.27million/ml vs. 16.5 (p= 0.008). Interviews conducted in 189 patients with IVF-achieved pregnancies: pregnancy loss was as well as other pregnancy related complications and hospital admissions did not differ between groups. Conclusion: IVF treatment parameters and IVF-achieved pregnancies appear to be unaffected by SARS-CoV-2 exposure and do not involve an excess risk. Sperm concentration seems to be compromised.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
N. A. du Fossé ◽  
E. E. L. O. Lashley ◽  
T. T. Treurniet ◽  
J. M. M. van Lith ◽  
S. le Cessie ◽  
...  

Abstract Background International guidelines recommend to offer supportive care during a next pregnancy to couples affected by recurrent pregnancy loss (RPL). In previous research, several options for supportive care have been identified and women’s preferences have been quantified. Although it is known that RPL impacts the mental health of both partners, male preferences for supportive care have hardly been explored. Methods A cross-sectional study was conducted in couples who visited a specialized RPL clinic in the Netherlands between November 2018 and December 2019. Both members of the couples received a questionnaire that quantified their preferences for supportive care in a next pregnancy and they were asked to complete this independently from each other. Preferences for each supportive care option were analysed on a group level (by gender) and on a couple level, by comparing preferences of both partners. Results Ninety-two questionnaires (completed by 46 couples) were analysed. The overall need for supportive care indicated on a scale from 1 to 10 was 6.8 for men and 7.9 for women (P = 0.002). Both genders preferred to regularly see the same doctor with knowledge of their obstetric history, to make a plan for the first trimester and to have frequent ultrasound examinations. A lower proportion of men preferred a doctor that shows understanding (80% of men vs. 100% of women, P = 0.004) and a doctor that informs on wellbeing (72% vs. 100%, P = ≤0.000). Fewer men preferred support from friends (48% vs. 74%, P = 0.017). Thirty-seven percent of men requested more involvement of the male partner at the outpatient clinic, compared to 70% of women (P = 0.007). In 28% of couples, partners had opposing preferences regarding peer support. Conclusions While both women and men affected by RPL are in need of supportive care, their preferences may differ. Current supportive care services may not entirely address the needs of men. Health care professionals should focus on both partners and development of novel supportive care programs with specific attention for men should be considered.


2021 ◽  
pp. 0192513X2110575
Author(s):  
Charisse Hay ◽  
Madalena Grobbelaar ◽  
Marika Guggisberg

Intimate Partner Violence (IPV) involves physical and sexual violence and coercive controlling behaviours to maximise power inequality in abusive relationships. Many women make the decision to exit abusive relationships due to the detrimental impact of IPV on their children. In a qualitative exploration, semi-structured in-depth interviews were conducted with 10 women recruited by purposive and snowballing sampling techniques. Two overarching themes of single mothers’ unique experiences of co-parenting with IPV were revealed through interpretative phenomenological analysis. The first theme was Continuous Victimisation, which indicated that post-separation victimisation was an extension of existing IPV whereby fathers used intimidation, threatening behaviours such as stalking and other monitoring tactics and the deliberate undermining of the mother–child relationship. The second theme identified was Systemic Challenges, indicating how court officials applied a ‘pro-contact’ approach and either minimised or denied mothers’ allegations of IPV and the impact on them and the children. The analysis found a persistent bias against mothers . Implications of the study are discussed before the article concludes that attitudinal change regarding IPV is required by decision makers in court processes with a recognition that abusive men may be unwilling to engage in cooperative parenting that focuses on the children’s developmental, social, emotional, psychological and physical needs.


Sign in / Sign up

Export Citation Format

Share Document